3SGW
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5LTZ
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![BU of 5ltz by Molmil](/molmil-images/mine/5ltz) | GmhA_mutant Q175E | 分子名称: | 1,2-ETHANEDIOL, D-ALTRO-HEPT-2-ULOSE 7-PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Vivoli, M, Harmer, N.J. | 登録日 | 2016-09-07 | 公開日 | 2017-12-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | A half-site multimeric enzyme achieves its cooperativity without conformational changes. Sci Rep, 7, 2017
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1O8J
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1O8G
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3SKF
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8DOV
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![BU of 8dov by Molmil](/molmil-images/mine/8dov) | Crystal structure of the Shr Hemoglobin Interacting Domain 2 (HID2) in complex with Hemoglobin | 分子名称: | GLYCEROL, Heme-binding protein Shr, Hemoglobin subunit alpha, ... | 著者 | Macdonald, R, Mahoney, B.J, Cascio, D, Clubb, R.T. | 登録日 | 2022-07-14 | 公開日 | 2023-01-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The Shr receptor from Streptococcus pyogenes uses a cap and release mechanism to acquire heme-iron from human hemoglobin. Proc.Natl.Acad.Sci.USA, 120, 2023
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1CHI
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6H2E
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5MTR
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![BU of 5mtr by Molmil](/molmil-images/mine/5mtr) | Crystal structure of M. tuberculosis InhA inhibited by PT512 | 分子名称: | 2-[4-[(4-cyclopentyl-1,2,3-triazol-1-yl)methyl]-2-oxidanyl-phenoxy]benzenecarbonitrile, CHLORIDE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... | 著者 | Eltschkner, S, Pschibul, A, Spagnuolo, L.A, Yu, W, Tonge, P.J, Kisker, C. | 登録日 | 2017-01-10 | 公開日 | 2017-02-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors. J. Am. Chem. Soc., 139, 2017
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6H7E
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![BU of 6h7e by Molmil](/molmil-images/mine/6h7e) | GEF regulatory domain | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ... | 著者 | Ferrandez, Y, Cherfils, J, Peurois, F. | 登録日 | 2018-07-31 | 公開日 | 2020-02-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Membranes prime the RapGEF EPAC1 to transduce cAMP signaling. Nat Commun, 14, 2023
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8CJC
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![BU of 8cjc by Molmil](/molmil-images/mine/8cjc) | F515A variant of the CODH/ACS complex of C. hydrogenoformans | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CO-methylating acetyl-CoA synthase, ... | 著者 | Ruickoldt, J, Jeoung, J, Lennartz, F, Dobbek, H. | 登録日 | 2023-02-13 | 公開日 | 2024-02-21 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Coupling CO 2 Reduction and Acetyl-CoA Formation: The Role of a CO Capturing Tunnel in Enzymatic Catalysis. Angew.Chem.Int.Ed.Engl., 63, 2024
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1OFK
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1ON7
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5MTQ
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![BU of 5mtq by Molmil](/molmil-images/mine/5mtq) | Crystal structure of M. tuberculosis InhA inhibited by PT511 | 分子名称: | 2-[4-[(4-cyclohexyl-1,2,3-triazol-1-yl)methyl]-2-oxidanyl-phenoxy]benzenecarbonitrile, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Eltschkner, S, Pschibul, A, Spagnuolo, L.A, Yu, W, Tonge, P.J, Kisker, C. | 登録日 | 2017-01-10 | 公開日 | 2017-02-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors. J. Am. Chem. Soc., 139, 2017
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5M6B
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6XDK
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3SNY
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3SMR
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![BU of 3smr by Molmil](/molmil-images/mine/3smr) | Crystal structure of human WD repeat domain 5 with compound | 分子名称: | 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... | 著者 | Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-06-28 | 公開日 | 2011-08-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
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3SO1
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5LMH
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![BU of 5lmh by Molmil](/molmil-images/mine/5lmh) | High dose Thaumatin - 160-200 ms. | 分子名称: | L(+)-TARTARIC ACID, Thaumatin-1 | 著者 | Schubert, R, Kapis, S, Heymann, M, Giquel, Y, Bourenkov, G, Schneider, T, Betzel, C, Perbandt, M. | 登録日 | 2016-07-30 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | A multicrystal diffraction data-collection approach for studying structural dynamics with millisecond temporal resolution. IUCrJ, 3, 2016
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6HMM
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![BU of 6hmm by Molmil](/molmil-images/mine/6hmm) | POLYADPRIBOSYL GLYCOHYDROLASE IN COMPLEX WITH PDD00013907 | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Poly(ADP-ribose) glycohydrolase, ... | 著者 | Tucker, J.A, Brassington, C, Hassall, G. | 登録日 | 2018-09-12 | 公開日 | 2018-11-14 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides. J.Med.Chem., 61, 2018
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6HSQ
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1TVK
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![BU of 1tvk by Molmil](/molmil-images/mine/1tvk) | The binding mode of epothilone A on a,b-tubulin by electron crystallography | 分子名称: | EPOTHILONE A, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Nettles, J.H, Li, H, Cornett, B, Krahn, J.M, Snyder, J.P, Downing, K.H. | 登録日 | 2004-06-29 | 公開日 | 2004-09-14 | 最終更新日 | 2023-08-23 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.89 Å) | 主引用文献 | The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography Science, 305, 2004
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6HSA
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1RMS
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![BU of 1rms by Molmil](/molmil-images/mine/1rms) | CRYSTAL STRUCTURES OF RIBONUCLEASE MS COMPLEXED WITH 3'-GUANYLIC ACID A GP*C ANALOGUE, 2'-DEOXY-2'-FLUOROGUANYLYL-3',5'-CYTIDINE | 分子名称: | GUANOSINE-3'-MONOPHOSPHATE, RIBONUCLEASE MS | 著者 | Nonaka, T, Mitsui, Y, Nakamura, K.T. | 登録日 | 1991-12-02 | 公開日 | 1992-07-15 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of ribonuclease Ms (as a ribonuclease T1 homologue) complexed with a guanylyl-3',5'-cytidine analogue. Biochemistry, 32, 1993
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