5M2Y
 
 | | Structure of TssK C-terminal domain from E. coli T6SS | | 分子名称: | TssK C | | 著者 | Cambillau, C, Nguyen, V.S, Spinelli, S, Desmyter, A, Legrand, P. | | 登録日 | 2016-10-13 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
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8R0S
 | | Structure of reverse transcriptase from Cauliflower Mosaic Virus in complex with RNA/DNA hybrid | | 分子名称: | DNA (5'-D(*GP*CP*TP*AP*CP*GP*CP*AP*CP*TP*GP*CP*TP*GP*GP*A)-3'), Enzymatic polyprotein, RNA (5'-R(*GP*UP*CP*CP*AP*GP*CP*AP*GP*UP*GP*CP*GP*UP*AP*GP*C)-3') | | 著者 | Prabaharan, C, Figiel, M, Chamera, S, Szczepanowski, R, Nowak, E, Nowotny, M. | | 登録日 | 2023-10-31 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural and biochemical characterization of cauliflower mosaic virus reverse transcriptase.
J.Biol.Chem., 300, 2024
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1CDW
 | | HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA | | 分子名称: | DNA (5'-D(*CP*AP*GP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*CP*TP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)) | | 著者 | Nikolov, D.B, Chen, H, Halay, E.D, Hoffmann, A, Roeder, R.G, Burley, S.K. | | 登録日 | 1996-04-11 | | 公開日 | 1996-12-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of a human TATA box-binding protein/TATA element complex.
Proc.Natl.Acad.Sci.USA, 93, 1996
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1VJI
 | | Gene Product of At1g76680 from Arabidopsis thaliana | | 分子名称: | 12-oxophytodienoate reductase (OPR1), FLAVIN MONONUCLEOTIDE | | 著者 | Wesenberg, G.E, Smith, D.W, Phillips Jr, G.N, Johnson, K.A, Bingman, C.A, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2004-02-24 | | 公開日 | 2004-03-16 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | | 主引用文献 | X-ray structure of Arabidopsis At1g77680, 12-oxophytodienoate reductase isoform 1.
Proteins, 61, 2005
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8QID
 | | Structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with fragment | | 分子名称: | 1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxylic acid, Phosphopantetheine adenylyltransferase | | 著者 | Thomas, S.E, McCarthy, W.J, Coyne, A.G, Blundell, T.L. | | 登録日 | 2023-09-12 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | A Fragment-Based Competitive 19 F LB-NMR Platform For Hotspot-Directed Ligand Profiling.
Angew.Chem.Int.Ed.Engl., 63, 2024
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7ACP
 | | Serial synchrotron structure of dehaloperoxidase B | | 分子名称: | Dehaloperoxidase B, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | 著者 | Moreno Chicano, T, Ebrahim, A.E, Axford, D.A, Sherrell, D.A, Worrall, J.W, Strange, R.W, Owen, R.L, Hough, M.A. | | 登録日 | 2020-09-11 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | SFX structure of dehaloperoxidase B in the ferric form
to be published
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1A50
 | | CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE | | 分子名称: | 5-FLUOROINDOLE PROPANOL PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... | | 著者 | Schneider, T.R, Gerhardt, E, Lee, M, Liang, P.-H, Anderson, K.S, Schlichting, I. | | 登録日 | 1998-02-18 | | 公開日 | 1999-03-30 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Loop closure and intersubunit communication in tryptophan synthase.
Biochemistry, 37, 1998
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8QIY
 | | Structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with inhibitor | | 分子名称: | 1-(2-aminophenyl)-5-(trifluoromethyl)pyrazole-4-carboxylic acid, Phosphopantetheine adenylyltransferase | | 著者 | Thomas, S.E, McCarthy, W.J, Coyne, A.G, Blundell, T.L. | | 登録日 | 2023-09-12 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.5149 Å) | | 主引用文献 | A Fragment-Based Competitive 19 F LB-NMR Platform For Hotspot-Directed Ligand Profiling.
Angew.Chem.Int.Ed.Engl., 63, 2024
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1A5S
 | | CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE AND L-SER BOUND AS AMINO ACRYLATE TO THE BETA SITE | | 分子名称: | 5-FLUOROINDOLE PROPANOL PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SERINE, ... | | 著者 | Schneider, T.R, Gerhardt, E, Lee, M, Liang, P.-H, Anderson, K.S, Schlichting, I. | | 登録日 | 1998-02-17 | | 公開日 | 1999-03-30 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Loop closure and intersubunit communication in tryptophan synthase.
Biochemistry, 37, 1998
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1DUQ
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8DS9
 | | LRRC8A:C in MSPE3D1 nanodisc top focus | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | 著者 | Kern, D.M, Brohawn, S.G. | | 登録日 | 2022-07-21 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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8DR8
 | | LRRC8A:C conformation 2 (oblong) top mask | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | 著者 | Kern, D.M, Brohawn, S.G. | | 登録日 | 2022-07-20 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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8DSA
 | | LRRC8A:C in MSP1E3D1 nanodisc | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | 著者 | Kern, D.M, Brohawn, S.G. | | 登録日 | 2022-07-21 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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8DRE
 | | LRRC8A:C conformation 2 (oblong) | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | 著者 | Kern, D.M, Brohawn, S.G. | | 登録日 | 2022-07-20 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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8DRK
 | | LRRC8A:C conformation 1 (round) top focus | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | 著者 | Kern, D.M, Brohawn, S.G. | | 登録日 | 2022-07-21 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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8QJ8
 | | Structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with inhibitor | | 分子名称: | 3-[3-(3-azanyl-2-cyano-phenyl)indol-1-yl]propanoic acid, Phosphopantetheine adenylyltransferase | | 著者 | Thomas, S.E, McCarthy, W.J, Coyne, A.G, Blundell, T.L. | | 登録日 | 2023-09-12 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.538 Å) | | 主引用文献 | A Fragment-Based Competitive 19 F LB-NMR Platform For Hotspot-Directed Ligand Profiling.
Angew.Chem.Int.Ed.Engl., 63, 2024
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8DS3
 | | LRRC8A:C conformation 1 (round) | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | 著者 | Kern, D.M, Brohawn, S.G. | | 登録日 | 2022-07-21 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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4LG2
 | | Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA | | 分子名称: | Polymerase cofactor, dsRNA | | 著者 | Bale, S, Julien, J.-P, Bornholdt, Z.A, Krois, A.S, Wilson, I.A, Saphire, E.O. | | 登録日 | 2013-06-27 | | 公開日 | 2013-07-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism.
J.Virol., 87, 2013
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6YV4
 | | STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 686 | | 分子名称: | 1,2-ETHANEDIOL, 1-cyclopropyl-2,5-dimethyl-pyrrole-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hillier, J, Ruza, R.R, Jones, E.Y. | | 登録日 | 2020-04-27 | | 公開日 | 2020-05-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
J.Med.Chem., 63, 2020
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2OBA
 | | Pseudomonas aeruginosa 6-pyruvoyl tetrahydrobiopterin synthase | | 分子名称: | Probable 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION | | 著者 | McGrath, T.E, Kisselman, G, Battaile, K, Romanov, V, Wu-Brown, J, Guthrie, J, Virag, C, Mansoury, K, Edwards, A.M, Pai, E.F, Chirgadze, N.Y. | | 登録日 | 2006-12-18 | | 公開日 | 2007-01-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Pseudomonas aeruginosa 6-pyruvoyl tetrahydrobiopterin synthase
TO BE PUBLISHED
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6Z83
 | | CK2 alpha bound to chemical probe SGC-CK2-1 | | 分子名称: | Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | | 著者 | Kraemer, A, Wells, C, Drewry, D.H, Pickett, J.E, Axtman, A.D, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-06-02 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.171 Å) | | 主引用文献 | Development of a potent and selective chemical probe for the pleiotropic kinase CK2.
Cell Chem Biol, 28, 2021
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5LQQ
 | | Structure of Autotaxin (ENPP2) with LM350 | | 分子名称: | 3-(6-chloranyl-2-methyl-1-phenyl-indol-3-yl)sulfanylbenzoic acid, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | | 著者 | Keune, W.J, Heidebrecht, T, Castelmur, E, Joosten, R.P, Perrakis, A. | | 登録日 | 2016-08-17 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.
J. Med. Chem., 60, 2017
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6V1D
 | | Crystal structure of human trefoil factor 1 | | 分子名称: | Trefoil factor 1 | | 著者 | Jarva, M.A, Lingford, J.P, John, A, Scott, N.E, Goddard-Borger, E.D. | | 登録日 | 2019-11-20 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Trefoil factors share a lectin activity that defines their role in mucus.
Nat Commun, 11, 2020
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1A7V
 | | CYTOCHROME C' FROM RHODOPSEUDOMONAS PALUSTRIS | | 分子名称: | CYTOCHROME C', PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Shibata, N, Iba, S, Misaki, S, Meyer, T.E, Bartsch, R.G, Cusanovich, M.A, Higuchi, Y, Yasuoka, N. | | 登録日 | 1998-03-18 | | 公開日 | 1998-06-17 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Basis for monomer stabilization in Rhodopseudomonas palustris cytochrome c' derived from the crystal structure.
J.Mol.Biol., 284, 1998
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6YV0
 | | STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLIDINE-3-CARBOXYLIC ACID FRAGMENT 587 | | 分子名称: | (3~{R})-1-(2-chlorophenyl)pyrrolidine-3-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ruza, R.R, Hillier, J, Jones, E.Y. | | 登録日 | 2020-04-27 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
J.Med.Chem., 63, 2020
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