5LQQ
Structure of Autotaxin (ENPP2) with LM350
Summary for 5LQQ
Entry DOI | 10.2210/pdb5lqq/pdb |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (8 entities in total) |
Functional Keywords | autotaxin, enpp2, inhibitor, lm350, ectonucleotide pyrophosphatase/phosphodiesterase, hydrolase |
Biological source | Rattus norvegicus (Norway Rat) |
Total number of polymer chains | 1 |
Total formula weight | 98291.71 |
Authors | Keune, W.J.,Heidebrecht, T.,Castelmur, E.,Joosten, R.P.,Perrakis, A. (deposition date: 2016-08-17, release date: 2016-12-28, Last modification date: 2024-01-10) |
Primary citation | Miller, L.M.,Keune, W.J.,Castagna, D.,Young, L.C.,Duffy, E.L.,Potjewyd, F.,Salgado-Polo, F.,Engel Garcia, P.,Semaan, D.,Pritchard, J.M.,Perrakis, A.,Macdonald, S.J.,Jamieson, C.,Watson, A.J. Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode. J. Med. Chem., 60:722-748, 2017 Cited by PubMed: 27982588DOI: 10.1021/acs.jmedchem.6b01597 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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