PDB: 66507 件ウェブページステータス検索Chemie searchBIRD

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3RT5	Lysozyme in 30% propanol 分子名称: ACETATE ION, CHLORIDE ION, ISOPROPYL ALCOHOL, ... 著者 Sharma, P, Solanki, A.K, Ashish 登録日 2011-05-03 公開日 2011-06-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal Structure of Lysozyme in 30% propanol to be published
3R1Y	CDK2 in complex with inhibitor KVR-1-134 分子名称: 1,2-ETHANEDIOL, 2-[(pyridin-3-ylmethyl)amino]benzamide, Cyclin-dependent kinase 2 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2011-03-11 公開日 2012-08-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3R7Y	CDK2 in complex with inhibitor KVR-2-88 分子名称: 1,2-ETHANEDIOL, 2-{[(2-aminopyrimidin-5-yl)methyl]amino}-4-(morpholin-4-yl)-5-nitrobenzamide, Cyclin-dependent kinase 2 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2011-03-23 公開日 2012-08-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3R8U	CDK2 in complex with inhibitor RC-1-132 分子名称: Cyclin-dependent kinase 2, [4-amino-2-(prop-2-en-1-ylamino)-1,3-thiazol-5-yl](naphthalen-2-yl)methanone 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2011-03-24 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3R9O	CDK2 in complex with inhibitor RC-2-143 分子名称: 4-amino-N-(3,5-difluorophenyl)-2-[(4-sulfamoylphenyl)amino]-1,3-thiazole-5-carboxamide, Cyclin-dependent kinase 2 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2011-03-25 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3RA6	Crystal structure of T. celer L30e E62A/K46A variant 分子名称: 50S ribosomal protein L30e 著者 Chan, C.H, Yu, T.H, Wong, K.B. 登録日 2011-03-27 公開日 2011-10-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Stabilizing salt-bridge enhances protein thermostability by reducing the heat capacity change of unfolding Plos One, 6, 2011
3TKH	Crystal structure of Chk1 in complex with inhibitor S01 分子名称: 1-(morpholin-4-yl)-2-[4-(2-{[5-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}pyridin-4-yl)piperazin-1-yl]ethanone, SULFATE ION, Serine/threonine-protein kinase Chk1 著者 Yan, Y, Ikuta, M. 登録日 2011-08-26 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates. Bioorg.Med.Chem.Lett., 22, 2012
3TOQ	Acylphosphatase with mesophilic surface and thermophilic core 分子名称: Acylphosphatase-1, PHOSPHATE ION 著者 Yu, T.H. 登録日 2011-09-06 公開日 2012-09-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Protein surface is the preferred region for thermostability engineering To be Published
3TMC	Bd1817, a HDG"Y"P protein from Bdellovibrio bacteriovorus 分子名称: DIMETHYL SULFOXIDE, FE (III) ION, PHOSPHATE ION, ... 著者 Lovering, A.L. 登録日 2011-08-31 公開日 2011-10-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 The structure of an unconventional HD-GYP protein from Bdellovibrio reveals the roles of conserved residues in this class of cyclic-di-GMP phosphodiesterases. MBio, 2, 2011
3TNV	Acylphosphatase with thermophilic surface and mesophilic core 分子名称: Acylphosphatase, PHOSPHATE ION 著者 Yu, T.H, Chan, C.H. 登録日 2011-09-02 公開日 2012-09-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Protein surface is a preferred site for thermostability engineering To be Published
3TWJ	Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447 分子名称: 1,2-ETHANEDIOL, 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea, Rho-associated protein kinase 1 著者 Martin, M.P, Zhu, J.-Y, Schonbrunn, E. 登録日 2011-09-21 公開日 2012-08-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer. Cancer Res., 72, 2012
3U6F	Mouse TREX1 D200N mutant 分子名称: 1,4-BUTANEDIOL, 5'-D(*GP*AP*CP*G)-3', MAGNESIUM ION, ... 著者 Bailey, S.L, Harvey, S, Perrino, F.W, Hollis, T. 登録日 2011-10-12 公開日 2011-12-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. Dna Repair, 11, 2012
3TKI	Crystal structure of Chk1 in complex with inhibitor S25 分子名称: N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide, SULFATE ION, Serine/threonine-protein kinase Chk1 著者 Yan, Y, Ikuta, M. 登録日 2011-08-26 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates. Bioorg.Med.Chem.Lett., 22, 2012
3TO2	Structure of HLA-A*0201 complexed with peptide Md3-C9 derived from a clustering region of restricted cytotoxic T lymphocyte epitope from SARS-CoV M protein 分子名称: Beta-2-microglobulin, MHC class I antigen, Md3-C9 peptide derived from Membrane glycoprotein 著者 Liu, J, Qi, J, Gao, F, Yan, J, Gao, G.F. 登録日 2011-09-03 公開日 2012-08-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Functional and Structural Definition of a Clustering Region of HLA-A2-restricted Cytotoxic T Lymphocyte Epitopes Sci.Technology Rev., 29, 2011
3U67	Crystal structure of the N-terminal domain of Hsp90 from Leishmania major(LmjF33.0312)in complex with ADP 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 83-1, ... 著者 Pizarro, J.C, Wernimont, A.K, Hutchinson, A, Mackenzie, F, Fairlamb, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Ferguson, M.A.J, Hui, R, Hills, T, Structural Genomics Consortium (SGC) 登録日 2011-10-12 公開日 2012-05-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. PLoS Negl Trop Dis, 7, 2013
7VSX	Crystal structure of QL-nanoKAZ (Reverse mutant of nanoKAZ with L18Q and V27L) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, QLnK 著者 Tomabechi, Y, Sekine, S, Shirouzu, M, Takamitsu, H, Satoshi, I. 登録日 2021-10-27 公開日 2022-08-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.698 Å) 主引用文献 Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate. Plos One, 17, 2022
7F5W	Conserved and divergent strigolactone signaling in Saccharum spontaneum 分子名称: High tillering and dwarf 2 protein 著者 Zhao, Q.Q, Ming, Z.H. 登録日 2021-06-23 公開日 2022-05-04 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.654 Å) 主引用文献 Identification of Conserved and Divergent Strigolactone Receptors in Sugarcane Reveals a Key Residue Crucial for Plant Branching Control. Front Plant Sci, 12, 2021
3UE8	Kynurenine Aminotransferase II Inhibitors 分子名称: (5-hydroxy-4-{[(1-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, CHLORIDE ION, Kynurenine/alpha-aminoadipate aminotransferase, ... 著者 Dounay, A.B, Anderson, M, Bechle, B.M, Campbell, B.M, Claffey, M.M, Evdokimov, A, Edelweiss, E, Fonseca, K.R, Gan, X, Ghosh, S, Hayward, M.M, Horner, W, Kim, J.Y, McAllister, L.A, Pandit, J, Paradis, V, Parikh, V.D, Reese, M.R, Rong, S.B, Salafia, M.A, Schuyten, K, Strick, C.A, Tuttle, J.B, Valentine, J, Wang, H, Zawadzke, L.E, Verhoest, P.R. 登録日 2011-10-28 公開日 2012-02-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett, 3, 2012
4BCX	gamma 2 adaptin EAR domain crystal structure 分子名称: 1,3-PROPANDIOL, AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2, IMIDAZOLE 著者 Juergens, M.C, Voros, J, Rautureau, G, Shepherd, D, Pye, V.E, Muldoon, J, Johnson, C.M, Ashcroft, A, Freund, S.M.V, Ferguson, N. 登録日 2012-10-03 公開日 2013-07-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Hepatitis B Virus Pres1 Domain Hijacks Host Trafficking Proteins by Motif Mimicry. Nat.Chem.Biol., 9, 2013
3UIW	Zebrafish Grx2 (APO) 分子名称: GLUTATHIONE, Glutaredoxin 2, SULFATE ION 著者 McDonough, M.A, Johansson, C. 登録日 2011-11-06 公開日 2013-03-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.601 Å) 主引用文献 A New Mode of Iron-sulfur Cluster Coordination in Glutaredoxins is Crucial for Axonogenesis To be Published
3UPI	Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors 分子名称: (3S)-6-(2,5-difluorobenzyl)-3-methyl-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase 著者 Velazquez, F, Venkataraman, S, Lesburg, C.A, Duca, J.S, Rosenblum, S.B, Kozlowski, J.A, Njoroge, F.G. 登録日 2011-11-18 公開日 2012-01-25 最終更新日 2012-02-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors. Org.Lett., 14, 2012
3V2M	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Aggarwal, M, McKenna, A. 登録日 2011-12-12 公開日 2012-12-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.471 Å) 主引用文献 Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II To be Published
4DOB	Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-monochlororomethylene triphosphate: Stereoselective binding of R-isomer 分子名称: 5'-O-[(R)-{[(R)-[(R)-chloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2'-deoxyguanosine, C C G A C C G C G C A T C A G C, CHLORIDE ION, ... 著者 Batra, V.K. 登録日 2012-02-09 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Beta,Gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases J.Am.Chem.Soc., 134, 2012
2FR7	Crystal Structure of Cytochrome P450 CYP199A2 分子名称: PROTOPORPHYRIN IX CONTAINING FE, putative cytochrome P450 著者 Rao, Z, Wong, L.L, Xu, F, Bell, S.G. 登録日 2006-01-19 公開日 2007-01-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris J.Mol.Biol., 383, 2008
4DOA	Ternary complex of dna polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-monofluoromethylene triphosphate: non-interactive binding of s-isomer 分子名称: 2'-deoxy-5'-O-[(R)-{[(R)-[(S)-fluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, C C G A C C G C G C A T C A G C, CHLORIDE ION, ... 著者 Batra, V.K. 登録日 2012-02-09 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.051 Å) 主引用文献 Beta,gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases J.Am.Chem.Soc., 134, 2012

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