4DOB
Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-monochlororomethylene triphosphate: Stereoselective binding of R-isomer
Summary for 4DOB
Entry DOI | 10.2210/pdb4dob/pdb |
Related | 4DO9 4DOA 4DOC |
Descriptor | DNA polymerase beta, C C G A C C G C G C A T C A G C, G C T G A T G C G (DOC), ... (9 entities in total) |
Functional Keywords | stereoselectivity, polymerase, dna polymerase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P06746 |
Total number of polymer chains | 4 |
Total formula weight | 48462.04 |
Authors | Batra, V.K. (deposition date: 2012-02-09, release date: 2012-06-13, Last modification date: 2023-09-13) |
Primary citation | Wu, Y.,Zakharova, V.M.,Kashemirov, B.A.,Goodman, M.F.,Batra, V.K.,Wilson, S.H.,McKenna, C.E. Beta,Gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases J.Am.Chem.Soc., 134:8734-8737, 2012 Cited by PubMed: 22397499DOI: 10.1021/ja300218x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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