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3TWJ

Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447

Summary for 3TWJ
Entry DOI10.2210/pdb3twj/pdb
DescriptorRho-associated protein kinase 1, 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordskinase, dimer, dimerization, myosin, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q13464
Total number of polymer chains4
Total formula weight190781.59
Authors
Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2011-09-21, release date: 2012-08-22, Last modification date: 2023-09-13)
Primary citationPatel, R.A.,Forinash, K.D.,Pireddu, R.,Sun, Y.,Sun, N.,Martin, M.P.,Schonbrunn, E.,Lawrence, N.J.,Sebti, S.M.
RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer.
Cancer Res., 72:5025-5034, 2012
Cited by
PubMed: 22846914
DOI: 10.1158/0008-5472.CAN-12-0954
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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