PDB: 223790 件ウェブページステータス検索Chemie searchBIRD

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4UAK	MRCK beta in complex with ADP 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Schuettelkopf, A.W. 登録日 2014-08-10 公開日 2014-10-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Commun. Signal, 12, 2014
4UBF	HsMCAK motor domain complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF2C, MAGNESIUM ION 著者 Welburn, J.P.I, Talapatra, S.K. 登録日 2014-08-12 公開日 2015-05-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch. Elife, 4, 2015
4UBQ	Crystal Structure of IMP-2 Metallo-beta-Lactamase from Acinetobacter spp. 分子名称: ACETATE ION, Beta-lactamase, ZINC ION 著者 Yamaguchi, Y, Matsueda, S, Matsunaga, K, Takashio, N, Toma-Fukai, S, Yamagata, Y, Shibata, N, Wachino, J, Shibayama, K, Arakawa, Y, Kurosaki, H. 登録日 2014-08-13 公開日 2014-12-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of IMP-2 metallo-beta-lactamase from Acinetobacter spp.: comparison of active-site loop structures between IMP-1 and IMP-2. Biol.Pharm.Bull., 38, 2015
4UC2	Crystal structure of translocator protein 18kDa (TSPO) from rhodobacter sphaeroides (A139T mutant) in P212121 space group 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, TETRAETHYLENE GLYCOL, TRANSLOCATOR PROTEIN TSPO 著者 Li, F, Liu, J, Zheng, Y, Garavito, R.M, Ferguson-Miller, S. 登録日 2014-08-13 公開日 2015-02-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism. Science, 347, 2015
4UF1	Deerpox virus DPV022 in complex with Bak BH3 分子名称: Antiapoptotic membrane protein, Bcl-2 homologous antagonist/killer, SULFATE ION 著者 Burton, D.R, Kvansakul, M. 登録日 2014-12-23 公開日 2015-08-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Basis of Deerpox Virus-Mediated Inhibition of Apoptosis. Acta Crystallogr.,Sect.D, 71, 2015
4UOI	Unexpected structure for the N-terminal domain of Hepatitis C virus envelope glycoprotein E1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GENOME POLYPROTEIN 著者 El Omari, K, Iourin, O, Kadlec, J, Harlos, K, Grimes, J.M, Stuart, D.I. 登録日 2014-06-04 公開日 2014-08-20 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.49 Å) 主引用文献 Unexpected Structure for the N-Terminal Domain of Hepatitis C Virus Envelope Glycoprotein E1 Acta Crystallogr.,Sect.D, 70, 2014
4UID	Crystal structure of the S-layer protein SbsC domains 4 and 5 分子名称: SURFACE LAYER PROTEIN 著者 Pavkov-Keller, T, Dordic, A, Egelseer, E.M, Sleytr, U.B, Keller, W. 登録日 2015-03-27 公開日 2016-04-13 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of the S-Layer Protein Sbsc To be Published
4UDE	An oligomerization domain confers pioneer properties to the LEAFY master floral regulator 分子名称: GINLFY PROTEIN, GLYCEROL, TETRAETHYLENE GLYCOL 著者 Nanao, M.H, Sayou, C, Dumas, R, Parcy, F. 登録日 2014-12-10 公開日 2016-03-02 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 A Sam Oligomerization Domain Shapes the Genomic Binding Landscape of the Leafy Transcription Factor Nat.Commun., 7, 2016
4UFY	Crystal structure of human tankyrase 2 in complex with TA-13 分子名称: 8-METHYL-2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE, GLYCEROL, SULFATE ION, ... 著者 Haikarainen, T, Lehtio, L. 登録日 2015-03-20 公開日 2016-04-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
4UG6	Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine) 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine), CHLORIDE ION, ... 著者 Holden, J.K, Poulos, T.L. 登録日 2015-03-22 公開日 2015-06-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry, 54, 2015
4UBL	KINETIC CRYSTALLOGRAPHY OF ALPHA_E7-CARBOXYLESTERSE FROM LUCILLA CUPRINA - ABSORBED X-RAY DOSE 9.26 MGy 分子名称: DIETHYL HYDROGEN PHOSPHATE, E3 著者 Jackson, C.J, Carr, P.D, Weik, M, Huber, T, Meirelles, T, Correy, G. 登録日 2014-08-13 公開日 2015-08-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography Structure, 24, 2016
4UB9	Structural and catalytic characterization of molinate hydrolase 分子名称: Molinate hydrolase, ZINC ION 著者 Leite, J.P, Duarte, M, Paiva, A, Ferreira-da-Silva, F, Matias, P.M, Nunes, O, Gales, L. 登録日 2014-08-12 公開日 2015-06-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides. Plos One, 10, 2015
4UCT	Fragment bound to H.influenza NAD dependent DNA ligase 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 2-amino-6-methyl-5-(propan-2-yloxy)-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium, DNA LIGASE 著者 Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. 登録日 2014-12-04 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56, 2015
6DRZ	Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8alpha)-N-[(2S)-1-hydroxybutan-2-yl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide, 5HT2B receptor, ... 著者 McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L. 登録日 2018-06-13 公開日 2018-08-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.102 Å) 主引用文献 Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25, 2018
4UQ6	Electron density map of GluA2em in complex with LY451646 and glutamate 分子名称: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID 著者 Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S. 登録日 2014-06-20 公開日 2014-08-13 最終更新日 2017-08-02 実験手法 ELECTRON MICROSCOPY (12.8 Å) 主引用文献 Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature, 514, 2014
4UFZ	Synthesis of Novel NAD Dependant DNA Ligase Inhibitors via Negishi Cross-Coupling: Development of SAR and Resistance Studies 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 5,7-bis(azanyl)-2-tert-butyl-4-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidine-6-carbonitrile, DNA LIGASE 著者 Murphy-Benenato, K.E, Boriack-Sjodin, P.A, Martinez-Botella, G, Carcanague, D, Gingipali, L, Gowravaram, M, Harang, J, Hale, M, Ioannidis, G, Jahic, H, Johnstone, M, Kutschke, A, Laganas, V.A, Loch, J, Oguto, H, Patel, S.J. 登録日 2015-03-20 公開日 2015-10-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Negishi Cross-Coupling Enabled Synthesis of Novel Nad(+)-Dependent DNA Ligase Inhibitors and Sar Development. Bioorg.Med.Chem.Lett., 25, 2015
4UE0	Structure of the bovine atadenovirus type 4 fibre head protein 分子名称: CARBONATE ION, FIBER, THIOCYANATE ION 著者 Nguyen, T.H, van Raaij, M.J. 登録日 2014-12-14 公開日 2015-06-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.17 Å) 主引用文献 Crystal structure of the fibre head domain of bovine adenovirus 4, a ruminant atadenovirus. Virol. J., 12, 2015
4UFW	Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 22) 分子名称: 2-oxopentadecyl-CoA, 4-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, CHLORIDE ION, ... 著者 Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. 登録日 2015-03-19 公開日 2016-02-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase Medchemcomm, 6, 2015
4UH1	Structure of rat neuronal nitric oxide synthase heme domain in complex with N1-(5-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)pyridin-3- yl)-N1,N2-dimethylethane-1,2-diamine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N1-(5-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)-N1,N2-dimethylethane-1,2-diamine, ... 著者 Li, H, Poulos, T.L. 登録日 2015-03-23 公開日 2015-07-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 2-Aminopyridines with a Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. J.Med.Chem., 58, 2015
4UPJ	HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 PROTEASE MUTANT WITH LYS 57 REPLACED BY LEU (K57L) COMPLEX WITH U097410 [4-HYDROXY-3-[1-[3-[[[[(TERT-BUTYLOXYCARBONYL) AMINOMETHYL]CARBONYL]AMINO]PHENYL]PROPYL]COUMARIN 分子名称: ({3-[1-(4-HYDROXY-2-OXO-2H-CHROMEN-3-YL)-PROPYL]-PHENYLCARBAMOYL}-METHYL)-CARBAMIC ACID TERT-BUTYL ESTER, HIV-2 PROTEASE 著者 Watenpaugh, K.D, Mulichak, A.M, Janakiraman, M.N. 登録日 1996-03-04 公開日 1996-10-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors. J.Med.Chem., 38, 1995
4UH2	Structure of rat neuronal nitric oxide synthase heme domain in complex with N1-(3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5-(trifluoromethyl)phenyl)-N1,N2-dimethylethane-1,2-diamine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N1-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)-5-(TRIFLUOROMETHYL)PHENYL)-N1,N2-DIMETHYLETHANE-1,2-DIAMINE, ... 著者 Li, H, Poulos, T.L. 登録日 2015-03-23 公開日 2015-07-15 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.991 Å) 主引用文献 2-Aminopyridines with a Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. J.Med.Chem., 58, 2015
6DRY	Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5HT2B receptor, ... 著者 McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L. 登録日 2018-06-13 公開日 2018-08-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.918 Å) 主引用文献 Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25, 2018
4UPF	Assembly principles of the unique cage formed by the ATPase RavA hexamer and the lysine decarboxylase LdcI decamer 分子名称: ATPASE RAVA, LYSINE DECARBOXYLASE, INDUCIBLE 著者 Malet, H, Liu, K, El Bakkouri, M, Chan, S.W.S, Effantin, G, Bacia, M, Houry, W.A, Gutsche, I. 登録日 2014-06-16 公開日 2014-08-20 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (7.5 Å) 主引用文献 Assembly Principles of a Unique Cage Formed by Hexameric and Decameric E. Coli Proteins. Elife, 3, 2014
4UF2	Deerpox virus DPV022 in complex with Bax BH3 分子名称: Antiapoptotic membrane protein, Apoptosis regulator BAX 著者 Burton, D.R, Kvansakul, M. 登録日 2014-12-23 公開日 2015-08-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Basis of Deerpox Virus-Mediated Inhibition of Apoptosis. Acta Crystallogr.,Sect.D, 71, 2015
4UFX	Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 19) 分子名称: 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. 登録日 2015-03-19 公開日 2016-02-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase Medchemcomm, 6, 2015

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