PDB: 1738 件ウェブページステータス検索Chemie searchBIRD

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5IBF	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 19a 分子名称: 4-(3'-amino[1,1'-biphenyl]-3-yl)-1H-pyrazol-5-amine, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C. 登録日 2016-02-22 公開日 2016-04-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5IBD	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 24a 分子名称: 4-(3'-amino[1,1'-biphenyl]-3-yl)-3-(4-methoxyphenyl)-1H-pyrazol-5-amine, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C. 登録日 2016-02-22 公開日 2016-04-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5IBE	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 25a 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[5-amino-4-(3'-amino[1,1'-biphenyl]-3-yl)-1H-pyrazol-3-yl]phenol, Mycocyclosin synthase, ... 著者 Levy, C. 登録日 2016-02-22 公開日 2016-04-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.624 Å) 主引用文献 Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
4KKY	Crystal structure of N-(1-Pyrene)acetamide labeled P450cam in substrate bound form. 分子名称: CAMPHOR, Camphor 5-monooxygenase, N-(pyren-1-yl)acetamide, ... 著者 Zhang, M, Goodin, D.B. 登録日 2013-05-06 公開日 2014-05-21 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 To be determined. To be Published
4BMM	Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-2',3, 5'-trifluoro-(1,1'-biphenyl)-4-carboxamide 分子名称: 4-[2,5-bis(fluoranyl)phenyl]-2-fluoranyl-N-[(2R)-3-(1H-indol-3-yl)-1-oxidanylidene-1-(pyridin-4-ylamino)propan-2-yl]benzamide, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-ALPHA DEMETHYLASE 著者 Choi, J.Y, Calvet, C.M, Gunatilleke, S.S, Roush, W.R, McKerrow, J.H, Podust, L.M. 登録日 2013-05-09 公開日 2014-06-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 4-Aminopyridyl-Based Cyp51 Inhibitors as Anti-Trypanosoma Cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency. J.Med.Chem., 57, 2014
4C0C	Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(2,4-difluorophenyl)piperazin-1-yl)-2-fluorobenzamide. 分子名称: 4-[4-[2,4-bis(fluoranyl)phenyl]piperazin-1-yl]-2-fluoranyl-N-[(2R)-3-(1H-indol-3-yl)-1-oxidanylidene-1-(pyridin-4-ylamino)propan-2-yl]benzamide, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Calvet, C.M, Vieira, D.F, Choi, J.Y, Cameron, M.D, Gut, J, Kellar, D, Siqueira-Neto, J.L, McKerrow, J.H, Roush, W.R, Podust, L.M. 登録日 2013-08-01 公開日 2014-08-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 4-Aminopyridyl-Based Cyp51 Inhibitors as Anti-Trypanosoma Cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency. J.Med.Chem., 57, 2014
8GZU	Cryo-EM structure of Tetrahymena thermophila respiratory Megacomplex MC (IV2+I+III2+II)2 分子名称: 2 iron, 2 sulfur cluster-binding protein, 2-oxoglutarate/malate carrier protein, ... 著者 Wu, M.C, Hu, Y.Q, Han, F.Z, Zhou, L. 登録日 2022-09-27 公開日 2023-06-14 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (4.18 Å) 主引用文献 Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae. Nat Commun, 14, 2023
8GYM	Cryo-EM structure of Tetrahymena thermophila respiratory mega-complex MC IV2+(I+III2+II)2 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... 著者 Wu, M.C, Hu, Y.Q, Han, F.Z, Zhou, L. 登録日 2022-09-23 公開日 2023-06-14 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae. Nat Commun, 14, 2023
1R7S	PUTIDAREDOXIN (Fe2S2 ferredoxin), C73G mutant 分子名称: FE2/S2 (INORGANIC) CLUSTER, Putidaredoxin 著者 Smith, N, Mayhew, M, Kelly, H, Robinson, H, Heroux, A, Holden, M.J, Gallagher, D.T. 登録日 2003-10-22 公開日 2004-04-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structure of C73G putidaredoxin from Pseudomonas putida. Acta Crystallogr.,Sect.D, 60, 2004
8HKD	Crystal structure of P450BSbeta-L78G/Q85F/F173S/G290I variant in complex with palmitoleic acid 分子名称: DI(HYDROXYETHYL)ETHER, Fatty-acid peroxygenase, PALMITOLEIC ACID, ... 著者 He, C, Wang, X, Li, F. 登録日 2022-11-25 公開日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Biocatalytic enantioselective gamma-C-H lactonization of aliphatic carboxylic acids Nat Synth, 2023
3LB8	Crystal structure of the covalent putidaredoxin reductase-putidaredoxin complex 分子名称: FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, Putidaredoxin, ... 著者 Sevrioukova, I.F. 登録日 2010-01-07 公開日 2010-02-23 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the putidaredoxin reductase x putidaredoxin electron transfer complex. J.Biol.Chem., 285, 2010
2IAG	Crystal structure of human prostacyclin synthase 分子名称: PROTOPORPHYRIN IX CONTAINING FE, Prostacyclin synthase, SODIUM ION 著者 Chiang, C.-W, Yeh, H.-C, Wang, L.-H, Chan, N.-L. 登録日 2006-09-08 公開日 2006-10-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structure of the Human Prostacyclin Synthase J.Mol.Biol., 364, 2006
2WLB	Adrenodoxin-like ferredoxin Etp1fd(516-618) of Schizosaccharomyces pombe mitochondria 分子名称: ELECTRON TRANSFER PROTEIN 1, MITOCHONDRIAL, FE2/S2 (INORGANIC) CLUSTER 著者 Mueller, J.J, Hannemann, F, Schiffler, B, Bernhardt, R, Heinemann, U. 登録日 2009-06-23 公開日 2010-08-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and Thermodynamic Characterization of the Adrenodoxin-Like Domain of the Electron-Transfer Protein Etp1 from Schizosaccharomyces Pombe. J.Inorg.Biochem., 105, 2011
1AYF	BOVINE ADRENODOXIN (OXIDIZED) 分子名称: ADRENODOXIN, FE2/S2 (INORGANIC) CLUSTER, GLYCEROL 著者 Mueller, A, Mueller, J.J, Heinemann, U. 登録日 1997-11-03 公開日 1998-12-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 New aspects of electron transfer revealed by the crystal structure of a truncated bovine adrenodoxin, Adx(4-108). Structure, 6, 1998
1XLQ	Crystal structure of reduced C73S putidaredoxin from Pseudomonas putida 分子名称: FE2/S2 (INORGANIC) CLUSTER, Putidaredoxin 著者 Sevrioukova, I.F. 登録日 2004-09-30 公開日 2005-10-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Redox-dependent Structural Reorganization in Putidaredoxin, a Vertebrate-type [2Fe-2S] Ferredoxin from Pseudomonas putida. J.Mol.Biol., 347, 2005
1XLN	Crystal structure of oxidized C73S/C85S putidaredoxin, a [2Fe-2S] ferredoxin from Pseudomonas putida 分子名称: FE2/S2 (INORGANIC) CLUSTER, Putidaredoxin 著者 Sevrioukova, I.F. 登録日 2004-09-30 公開日 2005-10-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Redox-dependent Structural Reorganization in Putidaredoxin, a Vertebrate-type [2Fe-2S] Ferredoxin from Pseudomonas putida. J.Mol.Biol., 347, 2005
1XLP	Structure of oxidized C73S putidaredoxin from Pseudomonas putida 分子名称: FE2/S2 (INORGANIC) CLUSTER, Putidaredoxin 著者 Sevrioukova, I.F. 登録日 2004-09-30 公開日 2005-10-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Redox-dependent structural reorganization in putidaredoxin, a vertebrate-type [2Fe-2S] ferredoxin from Pseudomonas putida. J.Mol.Biol., 347, 2005
1XLO	Structure of reduced C73S/C85S putidaredoxin, a [2Fe-2S] ferredoxin from Pseudomonas putida 分子名称: FE2/S2 (INORGANIC) CLUSTER, Putidaredoxin 著者 Sevrioukova, I.F. 登録日 2004-09-30 公開日 2005-10-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Redox-dependent Structural Reorganization in Putidaredoxin, a Vertebrate-type [2Fe-2S] Ferredoxin from Pseudomonas putida. J.Mol.Biol., 347, 2005
3FG2	Crystal Structure of Ferredoxin Reductase for the CYP199A2 System from Rhodopseudomonas palustris 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Putative rubredoxin reductase 著者 Xu, F. 登録日 2008-12-04 公開日 2009-09-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris Proteins, 77, 2009
4CK9	STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH (S)-1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethyl 4- isopropylphenylcarbamate (LFT) 分子名称: (1S)-1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethyl [4-(propan-2-yl)phenyl]carbamate, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-ALPHA DEMETHYLASE 著者 Friggeri, L, Wawrzak, Z, Tortorella, S, Lepesheva, G.I. 登録日 2013-12-31 公開日 2014-07-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma Cruzi Sterol 14Alpha-Demethylase: Two Regions of the Enzyme Molecule Potentiate its Inhibition. J.Med.Chem., 57, 2014
4UVR	Binding mode, selectivity and potency of N-indolyl-oxopyridinyl-4- amino-propanyl-based inhibitors targeting Trypanosoma cruzi CYP51 分子名称: Nalpha-{4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-2-fluorobenzoyl}-N-pyridin-4-yl-D-tryptophanamide, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-DEMETHYLASE, ... 著者 Vieira, D.F, Choi, J.Y, Calvet, C.M, Gut, J, Kellar, D, Siqueira-Neto, J.L, Johnston, J.B, McKerrow, J.H, Roush, W.R, Podust, L.M. 登録日 2014-08-08 公開日 2014-11-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Binding Mode and Potency of N-Indolyl-Oxopyridinyl-4-Amino-Propanyl-Based Inhibitors Targeting Trypanosoma Cruzi Cyp51 J.Med.Chem., 57, 2014
8SBI	Crystal structure of human sterol 14 alpha-demethylase (CYP51) in the ligand-free state 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE 著者 Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. 登録日 2023-04-03 公開日 2023-04-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Structural dynamics of sterol 14 alpha demethylases upon catalysis To Be Published
4COH	Crystal structure of Trypanosoma cruzi CYP51 bound to the sulfonamide derivative of the 4-aminopyridyl-based inhibitor 分子名称: 2-fluoranyl-N-[(2R)-3-(1H-indol-3-yl)-1-oxidanylidene-1-(pyridin-4-ylamino)propan-2-yl]-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)benzamide, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-ALPHA DEMETHYLASE 著者 Vieira, D.F, Choi, J.Y, Roush, W.R, Podust, L.M. 登録日 2014-01-28 公開日 2014-04-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Expanding the Binding Envelope of Cyp51 Inhibitors Targeting Trypanosoma Cruzi with 4-Aminopyridyl-Based Sulfonamide Derivatives Chembiochem, 15, 2014
7P5T	Structure of CYP142 from Mycobacterium tuberculosis in complex with inhibitor MEK216 分子名称: BROMIDE ION, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Snee, M, Kavanagh, M, Tunnicliffe, R, McLean, K, Levy, C, Munro, A. 登録日 2021-07-14 公開日 2022-11-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure of CYP142 from Mycobacterium tuberculosis in complex with inhibitor MEK216 To Be Published
6E8Q	S. CEREVISIAE CYP51 COMPLEXED WITH Posaconazole 分子名称: DODECYL-BETA-D-MALTOSIDE, Lanosterol 14-alpha demethylase, PENTAETHYLENE GLYCOL, ... 著者 Tyndall, J.D, Keniya, M.V, Sabherwal, M, Monk, B.C. 登録日 2018-07-30 公開日 2018-09-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161. Antimicrob. Agents Chemother., 63, 2019

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