8V2N
 
 | | Human SIRT3 co-crystallized with ligands, including p53-AMC peptide and Carba-NAD | | 分子名称: | CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLN-PRO-LYS-FDL, NAD-dependent protein deacetylase sirtuin-3, ... | | 著者 | Chakrabarti, R, Ghosh, A, Guan, X, Upadhyay, A, Dumpati, R.K, Munshi, S, Roy, S, Chall, S, Rahnamoun, A, Reverdy, C, Errasti, G, Delacroix, T. | | 登録日 | 2023-11-23 | | 公開日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion
biorxiv, 2023
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8K51
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8V4O
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6MGP
 | | Structure of human 4-1BB / 4-1BBL complex | | 分子名称: | ACETATE ION, GLYCEROL, Tumor necrosis factor ligand superfamily member 9, ... | | 著者 | Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. | | 登録日 | 2018-09-14 | | 公開日 | 2018-11-14 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
Nat Commun, 9, 2018
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7Y77
 | | Crystal structure of rice NAL1 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Protein NARROW LEAF 1 | | 著者 | Yan, J.J, Guan, Z.Y, Yin, P, Xiong, L.Z. | | 登録日 | 2022-06-21 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Serine protease NAL1 exerts pleiotropic functions through degradation of TOPLESS-related corepressor in rice.
Nat.Plants, 9, 2023
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7MO2
 | | Crystal Structure of the ZnF2 of Nucleoporin NUP153 in complex with Ran-GDP | | 分子名称: | GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | | 登録日 | 2021-05-01 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
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7Y8J
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8UZK
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8SA7
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5TPQ
 | | E. coli alkaline phosphatase D101A, D153A, R166S, E322A, K328A mutant | | 分子名称: | Alkaline phosphatase, PHOSPHATE ION, ZINC ION | | 著者 | Sunden, F, AlSadhan, I, Lyubimov, A.Y, Doukov, T, Swan, J, Herschlag, D. | | 登録日 | 2016-10-20 | | 公開日 | 2017-11-01 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution.
J. Biol. Chem., 292, 2017
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6MHF
 | | Galphai3 co-crystallized with GIV/Girdin | | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Girdin, ... | | 著者 | Rees, S.D, Kalogriopoulos, N.A, Ngo, T, Kopcho, N, Ilatovskiy, A, Sun, N, Komives, E, Chang, G, Ghosh, P, Kufareva, I. | | 登録日 | 2018-09-17 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
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8SBX
 | | Crystal Structure of 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from Klebsiella aerogenes (Apo, hexagonal form) | | 分子名称: | 2,3-dihydroxybenzoate-2,3-dehydrogenase, CHLORIDE ION, SULFATE ION | | 著者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2023-04-04 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from Klebsiella aerogenes (Apo, hexagonal form)
To be published
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7YIK
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8USF
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8K8M
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7OWL
 | | Odinarchaeota Adenylate kinase (OdinAK) in complex with CTP | | 分子名称: | Adenylate kinase, CYTIDINE-5'-TRIPHOSPHATE | | 著者 | Aberg-Zingmark, E, Grundstrom, C, Verma, A, Wolf-Watz, M, Sauer, U.H, Sauer-Eriksson, A.E. | | 登録日 | 2021-06-18 | | 公開日 | 2022-09-28 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases.
Sci Adv, 8, 2022
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5C0Y
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8USG
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8K5T
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5UB9
 | | Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni | | 分子名称: | ACETATE ION, ATP phosphoribosyltransferase, CHLORIDE ION, ... | | 著者 | Mittelstaedt, G, Jiao, W, Livingstone, E.K, Parker, E.J. | | 登録日 | 2016-12-20 | | 公開日 | 2017-12-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.
Biochem. J., 475, 2018
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7MU5
 | | Human DCTPP1 bound to Triptolide | | 分子名称: | MAGNESIUM ION, dCTP pyrophosphatase 1, triptolide | | 著者 | Hauk, G, Berger, J.M. | | 登録日 | 2021-05-14 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance
To Be Published
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5CFL
 | | Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p] | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CITRATE ANION, Stimulator of Interferon Genes | | 著者 | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | | 登録日 | 2015-07-08 | | 公開日 | 2015-08-26 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.836 Å) | | 主引用文献 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
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5UBJ
 | | Structure of an alpha-L-arabinofuranosidase (GH62) from Aspergillus nidulans | | 分子名称: | Alpha-L-arabinofuranosidase axhA-2, CALCIUM ION | | 著者 | Liberato, M.V, Contesini, F.J, Damasio, A.R, Squina, F.M. | | 登録日 | 2016-12-20 | | 公開日 | 2017-09-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and functional characterization of a highly secreted alpha-l-arabinofuranosidase (GH62) from Aspergillus nidulans grown on sugarcane bagasse.
Biochim. Biophys. Acta, 1865, 2017
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8V4A
 | | Proteus vulgaris tryptophan indole-lyase complexed with L-ethionine | | 分子名称: | (2E)-4-(ethylsulfanyl)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}butanoic acid, (E)-S-ethyl-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-homocysteine, DIMETHYL SULFOXIDE, ... | | 著者 | Phillips, R.S. | | 登録日 | 2023-11-28 | | 公開日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Proteus vulgaris tryptophan indole-lyase complexed with L-ethionine
To Be Published
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7OJU
 | | Chaetomium thermophilum Naa50 GNAT-domain in complex with bisubstrate analogue CoA-Ac-MVNAL | | 分子名称: | CARBOXYMETHYL COENZYME *A, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | 著者 | Weidenhausen, J, Kopp, J, Sinning, I. | | 登録日 | 2021-05-17 | | 公開日 | 2022-09-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
Int J Mol Sci, 23, 2022
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