8YBK
 
 | | Cryo-EM structure of the human nucleosome containing the H3.1 E97K mutant | | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kimura, T, Hirai, S, Kujirai, T, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-02-14 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K.
Genes Cells, 29, 2024
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9BDL
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8XBU
 | | The cryo-EM structure of the decameric RAD51 ring bound to the nucleosome with the linker DNA binding | | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2023-12-07 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (4.24 Å) | | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site.
Nature, 628, 2024
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8YBJ
 | | Cryo-EM structure of human nucleosome core particle composed of the Widom 601 DNA sequence | | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kimura, T, Hirai, S, Kujirai, T, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-02-14 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | | 主引用文献 | Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K.
Genes Cells, 29, 2024
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6T7D
 | | Structure of human Sox11 transcription factor in complex with a nucleosome | | 分子名称: | DNA (151-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. | | 登録日 | 2019-10-21 | | 公開日 | 2020-04-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function.
Nature, 580, 2020
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6T7C
 | | Structure of two copies of human Sox11 transcription factor in complex with a nucleosome | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. | | 登録日 | 2019-10-21 | | 公開日 | 2020-04-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function.
Nature, 580, 2020
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6T93
 | | Nucleosome with OCT4-SOX2 motif at SHL-6 | | 分子名称: | DNA (153-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | | 登録日 | 2019-10-25 | | 公開日 | 2020-05-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
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6TTI
 | | PKM2 in complex with Compound 6 | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, DIMETHYL SULFOXIDE, Pyruvate kinase PKM, ... | | 著者 | Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A. | | 登録日 | 2019-12-27 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
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6TTH
 | | PKM2 in complex with L-threonine | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, Pyruvate kinase PKM, THREONINE | | 著者 | Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A. | | 登録日 | 2019-12-27 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
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6TTQ
 | | PKM2 in complex with Compound 10 | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 1-propan-2-yl-3-pyridin-4-yl-urea, Pyruvate kinase PKM | | 著者 | Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A. | | 登録日 | 2019-12-30 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
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6V8U
 | | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a modified Kaiso binding sequence (KBS) | | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*CP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*GP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), ... | | 著者 | Nikolova, E.N, Stanfield, R.L, Dyson, H.J, Wright, P.E. | | 登録日 | 2019-12-12 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | | 主引用文献 | A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences.
Biochemistry, 59, 2020
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1A35
 | | HUMAN TOPOISOMERASE I/DNA COMPLEX | | 分子名称: | DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I) | | 著者 | Redinbo, M.R, Stewart, L, Kuhn, P, Champoux, J.J, Hol, W.G. | | 登録日 | 1998-01-29 | | 公開日 | 1998-08-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
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6UV4
 | | Crystal structure of the core domain of RNA helicase DDX17 with RNA pri-18a-oligo1 | | 分子名称: | 18a_oligo1, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Ngo, T.D, Partin, A.C, Nam, Y. | | 登録日 | 2019-11-01 | | 公開日 | 2020-01-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
Cell Rep, 29, 2019
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6UV3
 | | Crystal structure of the core domain of RNA helicase DDX17 with RNA pri-125a-oligo2 | | 分子名称: | 125a-oligo2, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Ngo, T.D, Partin, A.C, Nam, Y. | | 登録日 | 2019-11-01 | | 公開日 | 2020-01-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.597 Å) | | 主引用文献 | RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
Cell Rep, 29, 2019
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6UV0
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6UV1
 | | Crystal structure of RNA helicase DDX17 in complex of rU10 RNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Ngo, T.D, Partin, A.C, Nam, Y. | | 登録日 | 2019-11-01 | | 公開日 | 2020-01-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.307 Å) | | 主引用文献 | RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
Cell Rep, 29, 2019
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6UV2
 | | Crystal structure of the core domain of RNA helicase DDX17 with RNA pri-125a-oligo1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Ngo, T.D, Partin, A.C, Nam, Y. | | 登録日 | 2019-11-01 | | 公開日 | 2020-01-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.894 Å) | | 主引用文献 | RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
Cell Rep, 29, 2019
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6V74
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6V92
 | | RSC-NCP | | 分子名称: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC14, ... | | 著者 | Patel, A.B, Moore, C.M, Greber, B.J, Nogales, E. | | 登録日 | 2019-12-13 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (20 Å) | | 主引用文献 | Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement.
Elife, 8, 2019
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6VO5
 | | Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4 | | 分子名称: | ACETATE ION, GLYCEROL, Histone H4, ... | | 著者 | Halabelian, L, Zeng, H, Dong, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | | 登録日 | 2020-01-30 | | 公開日 | 2020-03-11 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4
to be published
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6TTF
 | | PKM2 in complex with Compound 5 | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 5-hydroxynaphthalene-1-sulfonamide, Pyruvate kinase PKM | | 著者 | Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A. | | 登録日 | 2019-12-27 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
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1A5U
 | | PYRUVATE KINASE COMPLEX WITH BIS MG-ATP-NA-OXALATE | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, OXALATE ION, ... | | 著者 | Larsen, T.M, Benning, M.M, Rayment, I, Reed, G.H. | | 登録日 | 1998-02-18 | | 公開日 | 1999-03-02 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure of the bis(Mg2+)-ATP-oxalate complex of the rabbit muscle pyruvate kinase at 2.1 A resolution: ATP binding over a barrel.
Biochemistry, 37, 1998
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6V76
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6USJ
 | | Structure of two nucleosomes bridged by human PARP2 | | 分子名称: | Histone H2A, Histone H2B type 1-J, Histone H3.1, ... | | 著者 | Gaullier, G, Bowerman, S, Luger, K. | | 登録日 | 2019-10-27 | | 公開日 | 2020-10-14 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (10.5 Å) | | 主引用文献 | Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
Plos One, 15, 2020
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6V4X
 | | Cryo-EM structure of an active human histone pre-mRNA 3'-end processing machinery at 3.2 Angstrom resolution | | 分子名称: | Cleavage and polyadenylation specificity factor subunit 2, Cleavage and polyadenylation specificity factor subunit 3, Small nuclear ribonucleoprotein E, ... | | 著者 | Sun, Y, Zhang, Y, Walz, T, Tong, L. | | 登録日 | 2019-12-02 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of an active human histone pre-mRNA 3'-end processing machinery.
Science, 367, 2020
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