PDB: 36939 件ウェブページステータス検索Chemie searchBIRD

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8JO4	Cryo-EM structure of a Legionella effector complexed with actin and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... 著者 Zhou, X.T, Wang, X.F, Tan, J.X, Zhu, Y.Q. 登録日 2023-06-07 公開日 2024-05-01 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling. Nature, 631, 2024
8J4L	X-ray crystal structure of F46C myoglobin with a covalently linked triazole group 分子名称: 1H-1,2,3-triazole-5-thiol, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE 著者 Yuan, H, Lin, Y.W. 登録日 2023-04-20 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 X-ray crystal structure of F46C myoglobin with a covalently linked triazole group To Be Published
8JO3	Cryo-EM structure of a Legionella effector complexed with actin and AMP 分子名称: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Zhou, X.T, Wang, X.F, Tan, J.X, Zhu, Y.Q. 登録日 2023-06-07 公開日 2024-05-01 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.66 Å) 主引用文献 Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling. Nature, 631, 2024
8J9B	LnaB-actin binary complex 分子名称: Actin gamma 1, Type IV secretion protein Dot 著者 Chen, T.T, Ouyang, S.Y. 登録日 2023-05-03 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Structure of Legionella effector LnaB-actin binary complex To Be Published
5NJ1	The X-ray structure of the adduct formed in the reaction between hen egg white lysozyme and arsenoplatin-1 分子名称: 1,2-ETHANEDIOL, Lysozyme C, NITRATE ION, ... 著者 Ferraro, G, Merlino, A. 登録日 2017-03-27 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent. J.Am.Chem.Soc., 141, 2019
5ABW	Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases 分子名称: 1-(3-CHLOROPHENYL)-5-(3,5-DIMETHYLISOXAZOL-4-YL)-6-METHYL-N-[4-(METHYLSULFONYL)BENZYL]-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 von Nussbaum, F, Li, V.M, Schaefer, M. 登録日 2015-08-10 公開日 2015-08-19 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg. Med. Chem. Lett., 25, 2015
5M3Y	Crystal structure of human glycosylated angiotensinogen 分子名称: Angiotensinogen, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Yan, Y, Read, R.J. 登録日 2016-10-17 公開日 2017-12-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for the specificity of renin-mediated angiotensinogen cleavage. J. Biol. Chem., 294, 2019
5LSH	human lysozyme in complex with a tetrasaccharide fragment of the O-chain of LPS from Klebsiella pneumoniae 分子名称: CHLORIDE ION, Lysozyme C, SODIUM ION, ... 著者 Zhang, R, Nifantiev, N.E, Krylov, V, Luetteke, T, Scheidig, A.J, Siebert, H.-C. 登録日 2016-08-26 公開日 2017-06-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.061 Å) 主引用文献 Lysozyme's lectin-like characteristics facilitates its immune defense function. Q. Rev. Biophys., 50, 2017
5LWU	Structure resulting from an endothiapepsin crystal soaked with a dimeric derivative of fragment 177 分子名称: ACETATE ION, DIMETHYL SULFOXIDE, Endothiapepsin, ... 著者 Schiebel, J, Heine, A, Klebe, G. 登録日 2016-09-19 公開日 2017-08-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.109 Å) 主引用文献 A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red Herring. Angew. Chem. Int. Ed. Engl., 56, 2017
5LUX	Homeobox transcription factor CDX1 bound to methylated DNA 分子名称: DNA (5'-D(P*GP*AP*GP*GP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*CP*CP*TP*C)-3'), ... 著者 Morgunova, E, Popov, A, Taipale, J. 登録日 2016-09-12 公開日 2017-05-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.23 Å) 主引用文献 Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
8OID	Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the N111S mutation 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. 登録日 2023-03-22 公開日 2023-08-09 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
5LYC	Cytochrome c in complex with phosphonato-calix[6]arene 分子名称: Cytochrome c iso-1, HEME C, SULFATE ION, ... 著者 Rennie, M.L, Crowley, P.B. 登録日 2016-09-27 公開日 2017-05-10 最終更新日 2019-09-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Protein Dimerization on a Phosphonated Calix[6]arene Disc. Angew. Chem. Int. Ed. Engl., 56, 2017
5LVI	Hen Egg White Lysozyme co-crystallized with [HIsq][trans-RuCl4(DMSO)(Isq)] 分子名称: ACETATE ION, CHLORIDE ION, Lysozyme C, ... 著者 Kurpiewska, K, Halajko, P, Lewinski, K. 登録日 2016-09-14 公開日 2016-09-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Ligand-dependent interaction of anticancer ruthenium complexes with hen egg white lysozyme and human lysozyme To Be Published
8OI6	Cryo-EM structure of the undecorated barbed end of filamentous beta/gamma actin 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. 登録日 2023-03-22 公開日 2023-08-09 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.59 Å) 主引用文献 Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
5LWT	Endothiapepsin in complex with a methoxylated derivative of fragment 177 分子名称: 4-methoxy-5,6,7-trimethyl-pyrrolo[3,4-d]pyridazine, ACETATE ION, DIMETHYL SULFOXIDE, ... 著者 Schiebel, J, Heine, A, Klebe, G. 登録日 2016-09-19 公開日 2017-08-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.069 Å) 主引用文献 A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red Herring. Angew. Chem. Int. Ed. Engl., 56, 2017
8OIY	Crystal structure of the R15908H missense variant of titin domain Fn3-3 分子名称: Titin 著者 Rees, M, Gautel, M. 登録日 2023-03-23 公開日 2023-08-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation. J.Struct.Biol., 215, 2023
5AHC	Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) 分子名称: (3R,3aS,4R,6aR)-4-[2-(methylamino)-2-oxoethoxy]hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, CHLORIDE ION, PROTEASE 著者 Hohlfeld, K, Wegner, J.K, Kesteleyn, B, Linclau, B, Unge, J. 登録日 2015-02-05 公開日 2015-05-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Disubstituted Bis-Thf Moieties as New P2 Ligands in Non-Peptidal HIV-1 Protease Inhibitors (II). J.Med.Chem., 58, 2015
8JYH	Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid C 分子名称: 7-[5-[(2~{S})-2-azanyl-3-oxidanyl-3-oxidanylidene-propyl]-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, MANGANESE (II) ION, Pol protein,Pol protein,HIV-1 Reverse Transcriptase RNase H active domain, ... 著者 Ito, Y, Lu, H, Kitajima, M, Ishikawa, H, Nakata, Y, Iwatani, Y, Hoshino, T. 登録日 2023-07-03 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86, 2023
8JYJ	Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid A 分子名称: 7-[5-(2-acetamidoethyl)-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, MANGANESE (II) ION, Pol protein,Pol protein,HIV-1 Reverse Transcriptase RNase H active domain, ... 著者 Ito, Y, Lu, H, Kitajima, M, Ishikawa, H, Nakata, Y, Iwatani, Y, Hoshino, T. 登録日 2023-07-03 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86, 2023
5AJR	Sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi in complex with the 1-tetrazole derivative VT-1161 ((R)-2-(2,4-Difluorophenyl)-1, 1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl) pyridin-2-yl)propan-2-ol) 分子名称: (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-ALPHA DEMETHYLASE 著者 Wawrzak, Z, Hoekstra, W, I Lepesheva, G. 登録日 2015-02-26 公開日 2015-12-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Clinical Candidate Vt-1161'S Antiparasitic Effect in Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme Cyp51 from Trypanosoma Cruzi. Antimicrob.Agents Chemother., 60, 2015
8JYI	Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid E 分子名称: 7-[5-(2-azanylethyl)-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, MANGANESE (II) ION, Pol protein,Pol protein,Ribonuclease H, ... 著者 Ito, Y, Lu, H, Kitajima, M, Ishikawa, H, Nakata, Y, Iwatani, Y, Hoshino, T. 登録日 2023-07-03 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86, 2023
8OI8	Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the R183W mutation 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. 登録日 2023-03-22 公開日 2023-08-16 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.28 Å) 主引用文献 Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
8JQV	Hen egg-white lysozyme solved from 1D fixed target delivery system 分子名称: Lysozyme C 著者 Kim, J, Park, S, Park, J. 登録日 2023-06-15 公開日 2023-09-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Application of Micro-Tubing Reeling System to Serial Femtosecond Crystallography Photonics, 2024
5M3X	Crystal structure of human angiotensin I-deleted angiotensinogen 分子名称: Angiotensinogen 著者 Yan, Y, Read, R.J. 登録日 2016-10-17 公開日 2017-12-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Structural basis for the specificity of renin-mediated angiotensinogen cleavage. J. Biol. Chem., 294, 2019
5A1P	Crystal structure of cytochrome P450 3A4 bound to progesterone and citrate 分子名称: CITRIC ACID, CYTOCHROME P450 3A4, PROGESTERONE, ... 著者 Sevrioukova, I, Poulos, T. 登録日 2015-05-04 公開日 2015-06-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Anion-Dependent Stimulation of Cyp3A4 Monooxygenase. Biochemistry, 54, 2015

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