PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

---

7SFY	Crystal structure of human Mis18ab_cc 分子名称: Protein Mis18-alpha, Protein Mis18-beta 著者 Park, S.H, Cho, U. 登録日 2021-10-04 公開日 2023-04-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance To Be Published
8FDW	Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2, ... 著者 Zhang, J, Shi, W, Cai, Y.F, Zhu, H.S, Peng, H.Q, Voyer, J, Volloch, S.R, Cao, H, Mayer, M.L, Song, K.K, Xu, C, Lu, J.M, Chen, B. 登録日 2022-12-05 公開日 2023-05-10 最終更新日 2023-07-26 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane. Nature, 619, 2023
7SSE	Crystal structure of the WDR domain of human DCAF1 in complex with CYCA-117-70 分子名称: DDB1- and CUL4-associated factor 1, N-[(3R)-1-(3-fluorophenyl)piperidin-3-yl]-6-(morpholin-4-yl)pyrimidin-4-amine 著者 Kimani, S, Owen, J, Li, A, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Shahani, V.M, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2021-11-10 公開日 2021-12-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets. J.Chem.Inf.Model., 63, 2023
6M95	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping: compound 1 分子名称: (4-benzylpiperidin-1-yl)[2-methoxy-4-(methylsulfanyl)phenyl]methanone, Mitogen-activated protein kinase 14 著者 Lane, W, Okada, K. 登録日 2018-08-22 公開日 2019-04-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1. Chemmedchem, 14, 2019
8G0Z	Mutant bacteriophage T4 gp41 helicase hexamer bound with single strand DNA and ATPgammaS in the stalled primosome 分子名称: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DnaB-like replicative helicase, MAGNESIUM ION, ... 著者 Feng, X, Li, H. 登録日 2023-02-01 公開日 2023-06-14 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 Structural basis of the T4 bacteriophage primosome assembly and primer synthesis. Nat Commun, 14, 2023
8FCN	Cryo-EM structure of p97:UBXD1 VIM-only state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCT	Cryo-EM structure of p97:UBXD1 lariat mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCP	Cryo-EM structure of p97:UBXD1 para state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.52 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
5NSX	Crystal structure of TNKS2 in complex with 2-(1H-indazol-5-yl)-3,4-dihydroquinazolin-4-one 分子名称: 2-(2~{H}-indazol-5-yl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-04-27 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NT4	Crystal structure of TNKS2 in complex with 2-[4-(morpholin-4-yl)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-[4-morpholin-4-yl]-3,4-dihydroquinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-04-27 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NUT	Crystal structure of TNKS2 in complex with 2-[4-(propan-2-yloxy)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-(4-propan-2-yloxyphenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-02 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
8FYU	Crystal structure of the human CHIP-TPR domain in complex with a 10mer acetylated tau peptide 分子名称: ACE-SER-SER-THR-GLY-SER-ILE-ASP-MET-VAL-ASP, E3 ubiquitin-protein ligase CHIP 著者 Wucherer, K, Bohn, M.F, Basu, K, Nadel, C.M, Gestwicki, J.E, Craik, C.S. 登録日 2023-01-26 公開日 2023-08-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.84839141 Å) 主引用文献 Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. Biorxiv, 2023
6LTB	Crystal Structure of Nonribosomal peptide synthetases (NRPS), FmoA3 (S1046A)-AMPPNP bound form 分子名称: Nonribosomal peptide synthetase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Senda, T, Harada, A. 登録日 2020-01-22 公開日 2021-02-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural and Functional Analyses of the Tridomain-Nonribosomal Peptide Synthetase FmoA3 for 4-Methyloxazoline Ring Formation. Angew.Chem.Int.Ed.Engl., 60, 2021
5O8I	Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) crystallized at P212121 space group, and refined to 1.27 A 分子名称: ADENOSINE-5'-DIPHOSPHATE, Histidine triad nucleotide-binding protein 1 著者 Dolot, R.M, Seda, A, Nawrot, B.C. 登録日 2017-06-13 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Differences in crystal packing as the key factor for stabilization of the N-terminal fragment of hHINT1 protein To Be Published
6LTA	Crystal Structure of Nonribosomal peptide synthetases (NRPS), FmoA3 (S1046A) 分子名称: ACRYLIC ACID, Nonribosomal peptide synthetase 著者 Senda, T, Harada, A. 登録日 2020-01-22 公開日 2021-02-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural and Functional Analyses of the Tridomain-Nonribosomal Peptide Synthetase FmoA3 for 4-Methyloxazoline Ring Formation. Angew.Chem.Int.Ed.Engl., 60, 2021
5NSP	Crystal structure of TNKS2 in complex with OD334 分子名称: 1-[4-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]phenyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile, BICARBONATE ION, GLYCEROL, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-04-26 公開日 2017-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J. Med. Chem., 60, 2017
5NVF	Crystal structure of TNKS2 in complex with 2-[4-(pyridin-2-yl)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-(4-pyridin-2-ylphenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-04 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NVR	Crystal structure of the Rif1 N-terminal domain (RIF1-NTD) from Saccharomyces cerevisiae 分子名称: Telomere length regulator protein RIF1 著者 Bunker, R.D, Shi, T, Thoma, N.H. 登録日 2017-05-04 公開日 2017-06-14 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (3.95 Å) 主引用文献 Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends. Nat. Struct. Mol. Biol., 24, 2017
4I8V	Human Cytochrome P450 1A1 in complex with alpha-naphthoflavone 分子名称: 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, Cytochrome P450 1A1, NITRATE ION, ... 著者 Walsh, A.A, Scott, E.E. 登録日 2012-12-04 公開日 2013-02-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism. J.Biol.Chem., 288, 2013
6LTC	Crystal Structure of Nonribosomal peptide synthetases (NRPS), FmoA3 (S1046A)-alpha-methyl-L-serine-AMP bound form 分子名称: ADENOSINE MONOPHOSPHATE, CHLORIDE ION, Nonribosomal peptide synthetase, ... 著者 Senda, T, Harada, A. 登録日 2020-01-22 公開日 2021-03-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural and Functional Analyses of the Tridomain-Nonribosomal Peptide Synthetase FmoA3 for 4-Methyloxazoline Ring Formation. Angew.Chem.Int.Ed.Engl., 60, 2021
6LTD	Crystal Structure of Nonribosomal peptide synthetases (NRPS), FmoA3 (S1046A)-alpha-methyl-L-serine-AMP bound form 分子名称: ADENOSINE MONOPHOSPHATE, Nonribosomal peptide synthetase, alpha-methyl-L-serine 著者 Senda, T, Harada, A. 登録日 2020-01-22 公開日 2021-03-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (4.1 Å) 主引用文献 Structural and Functional Analyses of the Tridomain-Nonribosomal Peptide Synthetase FmoA3 for 4-Methyloxazoline Ring Formation. Angew.Chem.Int.Ed.Engl., 60, 2021
5NVH	Crystal structure of TNKS2 in complex with 2-[4-(piperidin-1-yl)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-(4-piperidin-1-ylphenyl)-3~{H}-quinazolin-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-04 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
8FHS	Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution 分子名称: (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gao, S, Yao, X, Yan, N. 登録日 2022-12-15 公開日 2023-12-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
8G1T	Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P21 分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX 著者 Cowan, A.D, Colman, P.M, Czabotar, P.E, Miller, M.S. 登録日 2023-02-02 公開日 2023-12-27 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.092 Å) 主引用文献 Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 291, 2024
8FK9	Crystal Structure of the Tick Evasin EVA-ACA1001 Complexed to Human Chemokine CCL16 分子名称: C-C motif chemokine 16, Evasin P991 著者 Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. 登録日 2022-12-21 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structure of the Tick Evasin EVA-ACA1001 Complexed to Human Chemokine CCL16 To Be Published

<547548549550551552553554555556557558559560561562>