7ZB9
| Crystal structure of CYP124 in complex with inhibitor carbethoxyhexyl imidazole in the absence of glycerol (NoCryo) | 分子名称: | CHLORIDE ION, CYP124 in complex with inhibitor carbethoxyhexyl imidazole, MAGNESIUM ION, ... | 著者 | Bukhdruker, S, Varaksa, T, Marin, E, Gilep, A, Strushkevich, N, Borshchevskiy, V. | 登録日 | 2022-03-23 | 公開日 | 2023-01-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Structural insights into the effects of glycerol on ligand binding to cytochrome P450. Acta Crystallogr D Struct Biol, 79, 2023
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7YXF
| Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor | 分子名称: | 1-(2-piperazin-1-ylethyl)-5-pyridin-4-yl-indole, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... | 著者 | Snee, M, Katariya, M, Levy, C, Leys, D. | 登録日 | 2022-02-16 | 公開日 | 2023-03-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis. Chemistry, 29, 2023
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6KBH
| Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase | 分子名称: | Cytochrome P450 monooxygenase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | 著者 | Gong, R, Wu, L.J, Zhang, Y, Liu, Z, Dou, S, Zhang, R.G, Xu, J.H, Tang, C, Zhou, J.H. | 登録日 | 2019-06-25 | 公開日 | 2020-07-01 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase To Be Published
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1BVY
| COMPLEX OF THE HEME AND FMN-BINDING DOMAINS OF THE CYTOCHROME P450(BM-3) | 分子名称: | 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, PROTEIN (CYTOCHROME P450 BM-3), ... | 著者 | Sevrioukova, I.F, Li, H, Zhang, H, Peterson, J.A, Poulos, T.L. | 登録日 | 1998-09-21 | 公開日 | 1999-02-23 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structure of a cytochrome P450-redox partner electron-transfer complex. Proc.Natl.Acad.Sci.USA, 96, 1999
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6NBL
| Cytochrome P450cam-putidaredoxin complex bound to camphor and cyanide | 分子名称: | 1,1'-hexane-1,6-diyldipyrrolidine-2,5-dione, CALCIUM ION, CAMPHOR, ... | 著者 | Follmer, A.H, Tripathi, S.M, Poulos, T.L. | 登録日 | 2018-12-07 | 公開日 | 2019-03-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Ligand and Redox Partner Binding Generates a New Conformational State in Cytochrome P450cam (CYP101A1). J. Am. Chem. Soc., 141, 2019
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4PXH
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4PWV
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4TX3
| Complex of the X-domain and OxyB from Teicoplanin Biosynthesis | 分子名称: | 1,2-ETHANEDIOL, OxyB protein, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Peschke, M, Haslinger, K, Cryle, M.J. | 登録日 | 2014-07-02 | 公開日 | 2015-02-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis. Nature, 521, 2015
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2M56
| The structure of the complex of cytochrome P450cam and its electron donor putidaredoxin determined by paramagnetic NMR spectroscopy | 分子名称: | CAMPHOR, Camphor 5-monooxygenase, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Hiruma, Y, Hass, M.A.S, Ubbink, M. | 登録日 | 2013-02-14 | 公開日 | 2013-08-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The structure of the cytochrome p450cam-putidaredoxin complex determined by paramagnetic NMR spectroscopy and crystallography. J.Mol.Biol., 425, 2013
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8AMQ
| Crystal structure of the complex CYP143-FdxE from M. tuberculosis | 分子名称: | FE3-S4 CLUSTER, NICKEL (II) ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Bukhdruker, S, Varaksa, T, Smolskaya, S, Marin, E, Kapranov, I, Kovalev, K, Gilep, A, Strushkevich, N, Borshchevskiy, V. | 登録日 | 2022-08-03 | 公開日 | 2023-02-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450. Front Mol Biosci, 9, 2022
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6LAA
| Crystal structure of full-length CYP116B46 from Tepidiphilus thermophilus | 分子名称: | 1,2-ETHANEDIOL, CARBONATE ION, Cytochrome P450, ... | 著者 | Zhang, L.L, Ko, T.P, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2019-11-12 | 公開日 | 2020-06-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase. Nat Commun, 11, 2020
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6MCW
| Crystal structure of the P450 domain of the CYP51-ferredoxin fusion protein from Methylococcus capsulatus, complex with the detergent Anapoe-X-114 | 分子名称: | 23-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]-3,6,9,12,15,18,21-heptaoxatricosan-1-ol, Cytochrome P450 51, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Hargrove, T, Wawrzak, Z, Lamb, D.C, Lepesheva, G.I. | 登録日 | 2018-09-02 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14 alpha-Demethylases. Mol.Biol.Evol., 2020
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7M8I
| Human CYP11B2 and human adrenodoxin in complex with fadrozole | 分子名称: | 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile, Adrenodoxin, Cytochrome P450 11B2, ... | 著者 | Scott, E.E, Brixius-Anderko, S. | 登録日 | 2021-03-29 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin. J.Biol.Chem., 296, 2021
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8DMG
| CYP102A1 in Closed Conformation | 分子名称: | 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole, Bifunctional cytochrome P450/NADPH--P450 reductase, FLAVIN MONONUCLEOTIDE, ... | 著者 | Su, M, Xu, H. | 登録日 | 2022-07-08 | 公開日 | 2023-07-19 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Insight into the conformational dynamics of cytochrome P450 CYP102A1 enzyme using Cryo-EM To Be Published
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8DME
| CYP102A1 in Open Conformation | 分子名称: | 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole, Bifunctional cytochrome P450/NADPH--P450 reductase, FLAVIN MONONUCLEOTIDE, ... | 著者 | Su, M, Xu, H. | 登録日 | 2022-07-08 | 公開日 | 2023-07-19 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Insight into the conformational dynamics of cytochrome P450 CYP102A1 enzyme using Cryo-EM To Be Published
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3W9C
| Crystal structure of the electron transfer complex of cytochrome p450cam with putidaredoxin | 分子名称: | Camphor 5-monooxygenase, FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, ... | 著者 | Kikui, Y, Hiruma, Y, Hass, M.A, Koteishi, H, Ubbink, M, Nojiri, M. | 登録日 | 2013-04-03 | 公開日 | 2013-08-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The structure of the cytochrome p450cam-putidaredoxin complex determined by paramagnetic NMR spectroscopy and crystallography. J.Mol.Biol., 425, 2013
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3EJE
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7SNM
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3EJD
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3EJB
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5GXG
| High-resolution crystal structure of the electron transfer complex of cytochrome p450cam with putidaredoxin | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Camphor 5-monooxygenase, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Kikui, Y, Hiruma, Y, Ubbink, M, Nojiri, M. | 登録日 | 2016-09-17 | 公開日 | 2017-01-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Identification of productive and futile encounters in an electron transfer protein complex Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3NA0
| Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol | 分子名称: | (3alpha,8alpha,22R)-cholest-5-ene-3,20,22-triol, Adrenodoxin, mitochondrial, ... | 著者 | Strushkevich, N.V, MacKenzie, F, Tempel, W, Botchkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J.U, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-05-31 | 公開日 | 2010-09-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc.Natl.Acad.Sci.USA, 108, 2011
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3N9Z
| Crystal structure of human CYP11A1 in complex with 22-hydroxycholesterol | 分子名称: | (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol, Adrenodoxin, Cholesterol side-chain cleavage enzyme, ... | 著者 | Strushkevich, N.V, MacKenzie, F, Tempel, W, Botchkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J.U, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-05-31 | 公開日 | 2011-06-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc.Natl.Acad.Sci.USA, 108, 2011
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3NA1
| Crystal structure of human CYP11A1 in complex with 20-hydroxycholesterol | 分子名称: | (3alpha,8alpha)-cholest-5-ene-3,20-diol, Adrenodoxin, mitochondrial, ... | 著者 | Strushkevich, N.V, MacKenzie, F, Tempel, W, Botchkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J.U, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-05-31 | 公開日 | 2011-06-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc.Natl.Acad.Sci.USA, 108, 2011
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3N9Y
| Crystal structure of human CYP11A1 in complex with cholesterol | 分子名称: | Adrenodoxin, CHOLESTEROL, Cholesterol side-chain cleavage enzyme, ... | 著者 | Strushkevich, N.V, MacKenzie, F, Tempel, W, Botchkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J.U, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-05-31 | 公開日 | 2011-06-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc.Natl.Acad.Sci.USA, 108, 2011
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