7Y86
 
 | | CcpS mutant | | 分子名称: | UPF0297 protein A7J08_00425 | | 著者 | Tang, J.S, Ran, T.T, Wang, W.W, Fan, H.J. | | 登録日 | 2022-06-22 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | A link between STK signalling and capsular polysaccharide synthesis in Streptococcus suis.
Nat Commun, 14, 2023
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7Y8Z
 | | CcpS | | 分子名称: | UPF0297 protein A7J08_00425 | | 著者 | Tang, J.S, Ran, T.T, Wang, W.W, Fan, H.J. | | 登録日 | 2022-06-24 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | A link between STK signalling and capsular polysaccharide synthesis in Streptococcus suis.
Nat Commun, 14, 2023
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7UMX
 | | Crystal structure of Acinetobacter baumannii FabI in complex with NAD and (R,E)-3-(7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)acrylamide | | 分子名称: | (2E)-3-[(7R)-7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl]-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]prop-2-enamide, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Hajian, B. | | 登録日 | 2022-04-08 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections
Acs Cent.Sci., 8, 2022
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8QFB
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7OU8
 | | Human O-GlcNAc hydrolase in complex with DNJNAc-thiazolidines | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, O-GlcNAcase BT_4395, ... | | 著者 | Males, A, Davies, G.J, Gonzalez-Cuesta, M, Mellet, C.O, Fernandez, J.M.G, Sidhu, P, Ashmus, R, Busmann, J, Vocadlo, D.J, Foster, L. | | 登録日 | 2021-06-11 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications
J.Am.Chem.Soc., 144, 2022
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8QAR
 | | Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 98 | | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-1-[2-[4-[(4-methyl-1~{H}-pyrazol-3-yl)methyl]piperazin-1-yl]-1,3-thiazol-4-yl]-2,5,6,7-tetrahydroisoindol-4-one, Bromodomain-containing protein 4 | | 著者 | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | 登録日 | 2023-08-23 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines
To be published
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7OU6
 | | Human O-GlcNAc hydrolase in complex with DNJNAc-thiazolidines | | 分子名称: | Protein O-GlcNAcase, ~{N}-[(3~{Z},6~{S},7~{R},8~{R},8~{a}~{S})-7,8-bis(oxidanyl)-3-(phenylmethyl)imino-1,5,6,7,8,8~{a}-hexahydro-[1,3]thiazolo[3,4-a]pyridin-6-yl]ethanamide | | 著者 | Males, A, Davies, G.J, Gonzalez-Cuesta, M, Mellet, C.O, Fernandez, J.M.G, Sidhu, P, Ashmus, R, Busmann, J, Vocadlo, D.J, Foster, L. | | 登録日 | 2021-06-11 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications
J.Am.Chem.Soc., 144, 2022
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8TXL
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8QAZ
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5G68
 | | Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2- amine | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, 7-({[3-(3-fluorophenyl)propyl]amino}methyl)quinolin-2-amine, ... | | 著者 | Holden, J.K, Poulos, T.L. | | 登録日 | 2016-06-18 | | 公開日 | 2016-09-21 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.
Biochemistry, 55, 2016
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8QB2
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7UVQ
 | | Pfs230 domain 1 bound by RUPA-97 and 15C5 Fabs | | 分子名称: | Fab Heavy Chain, Fab Kappa Light Chain, Gametocyte surface protein P230 | | 著者 | Ivanochko, D, Julien, J.P. | | 登録日 | 2022-05-02 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Immunity, 56, 2023
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8QB0
 | | Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 2 | | 分子名称: | 2-[4-(3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-2~{H}-isoindol-1-yl)-1,3-thiazol-2-yl]guanidine, NITRATE ION, Peregrin | | 著者 | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | 登録日 | 2023-08-23 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines
To be published
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7MQ3
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5C46
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7OKS
 | | X-ray structure of soluble EPCR in P212121 space group | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(5-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Erausquin, E, Dichiara, M.G, Lopez-Sagaseta, J. | | 登録日 | 2021-05-18 | | 公開日 | 2022-04-27 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR).
Sci Rep, 12, 2022
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5TW4
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8U1Y
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7XVL
 | | Crystal Structure of Nucleosome-H1.0 Linker Histone Assembly (sticky-169an DNA fragment) | | 分子名称: | DNA (169-MER), Histone H1.0, Histone H2A type 1-B/E, ... | | 著者 | Adhireksan, Z, Qiuye, B, Lee, P.L, Sharma, D, Padavattan, S, Davey, C.A. | | 登録日 | 2022-05-24 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.506 Å) | | 主引用文献 | Crystal Structure of Nucleosome-H1.0 Linker Histone Assembly (sticky-169an DNA fragment)
To Be Published
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7OKT
 | | X-ray structure of soluble EPCR in C2221 space group | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Endothelial protein C receptor, ... | | 著者 | Erausquin, E, Dichiara, M.G, Lopez-Sagaseta, J. | | 登録日 | 2021-05-18 | | 公開日 | 2022-04-27 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR).
Sci Rep, 12, 2022
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5GIV
 | | Crystal structure of M32 carboxypeptidase from Deinococcus radiodurans R1 | | 分子名称: | ACETATE ION, Carboxypeptidase 1, ZINC ION | | 著者 | Sharma, B, Singh, R, Yadav, P, Ghosh, B, Kumar, A, Jamdar, S.N, Makde, R.D. | | 登録日 | 2016-06-25 | | 公開日 | 2017-07-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Active site gate of M32 carboxypeptidases illuminated by crystal structure and molecular dynamics simulations
Biochim. Biophys. Acta, 1865, 2017
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7OV7
 | | The hybrid cage formed between Pizza6-S and Cu(II)-substituted trilacunary Keggin | | 分子名称: | COPPER (II) ION, POTASSIUM ION, Pizza6-S, ... | | 著者 | Vandebroek, L, Noguchi, H, Anyushin, A, Van Meervelt, L, Voet, A.R.D, Parac-Vogt, T.N. | | 登録日 | 2021-06-14 | | 公開日 | 2022-04-27 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Hierarchical Self-Assembly of a Supramolecular Protein-Metal Cage Encapsulating a Polyoxometalate Guest
Cryst.Growth Des., 2022
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5GGL
 | | Crystal structure of N-terminal domain of human protein O-mannose beta-1,2-N-acetylglucosaminyltransferase in complex with GlcNAc-alpha-pNP | | 分子名称: | 4-nitrophenyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside, Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 | | 著者 | Kuwabara, N, Senda, T, Kato, R. | | 登録日 | 2016-06-16 | | 公開日 | 2016-08-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of alpha-dystroglycan
Proc.Natl.Acad.Sci.USA, 113, 2016
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7YJF
 | | Crystal structure of the P450 BM3 heme domain mutant F87A/T268P/V78I in complex with N-imidazolyl-pentanoyl-L-phenylalanine and hydroxylamine | | 分子名称: | (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, HYDROXYAMINE, P450 BM3 heme domain mutant F87A/T268P/V78I, ... | | 著者 | Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y. | | 登録日 | 2022-07-20 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.515 Å) | | 主引用文献 | Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
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7MQ1
 | | C9A Streptococcus pneumoniae CstR in the reduced state, space group C2 | | 分子名称: | CHLORIDE ION, Copper-sensing transcriptional repressor csoR, GLYCEROL, ... | | 著者 | Fakhoury, J.N, Gonzalez-Gutierrez, G, Giedroc, D.P. | | 登録日 | 2021-05-05 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Functional asymmetry and chemical reactivity of CsoR family persulfide sensors.
Nucleic Acids Res., 49, 2021
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