8QB2

Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 79

Summary for 8QB2

• Entry DOI: 10.2210/pdb8qb2/pdb
• Related: 7QYO 8QAN 8QAZ 8QB0
• Descriptor: Peregrin, 1-[2-methyl-4-(3-methylbutyl)-5-(2-piperazin-1-yl-1,3-thiazol-4-yl)-1~{H}-pyrrol-3-yl]ethanone, NITRATE ION, ... (4 entities in total)
• Functional Keywords: four helical bundle, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 14126.22

Authors

Dalle Vedove, A.,Cazzanelli, G.,Lolli, G. (deposition date: 2023-08-24, release date: 2024-09-11)

• Primary citation: Cazzanelli, G.,Dalle Vedove, A.,Caflisch, A.,Lolli, G.; Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines; To be published,

Experimental method

X-RAY DIFFRACTION (1.42 Å)