PDB: 97310 件ウェブページステータス検索Chemie searchBIRD

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5AAU	Optimization of a novel binding motif to to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H- pyrido(3,4-b)indol-1-yl)phenyl)acrylic acid (AZD9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonist 分子名称: 3-(1-(4-Chlorophenyl)-3,4-dihydro-1H-pyrido(3,4-b)indol-2(9H)-yl)propanoic acid, ESTROGEN RECEPTOR 著者 Norman, R.A, Bradbury, R.H, de Almeida, C, Andrews, D.M, Ballard, P, Buttar, D, Callis, R.J, Currie, G.S, Curwen, J.O, Davies, C.D, de Savi, C, Donald, C.S, Feron, L.J.L, Glossop, S.C, Hayter, B.R, Karoutchi, G, Lamont, S.G, MacFaul, P, Moss, T, Pearson, S.E, Rabow, A.A, Tonge, M, Walker, G.E, Weir, H.M, Wilson, Z. 登録日 2015-07-28 公開日 2015-10-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist. J.Med.Chem., 58, 2015
4UBP	STRUCTURE OF BACILLUS PASTEURII UREASE INHIBITED WITH ACETOHYDROXAMIC ACID AT 1.55 A RESOLUTION 分子名称: ACETOHYDROXAMIC ACID, NICKEL (II) ION, PROTEIN (UREASE (CHAIN A)), ... 著者 Benini, S, Rypniewski, W.R, Wilson, K.S, Ciurli, S, Mangani, S. 登録日 1999-02-25 公開日 2000-03-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 The complex of Bacillus pasteurii urease with acetohydroxamate anion from X-ray data at 1.55 A resolution. J.Biol.Inorg.Chem., 5, 2000
1EQM	CRYSTAL STRUCTURE OF BINARY COMPLEX OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE WITH ADENOSINE-5'-DIPHOSPHATE 分子名称: 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Xiao, B, Blaszczyk, J, Ji, X. 登録日 2000-04-05 公開日 2001-04-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Unusual conformational changes in 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as revealed by X-ray crystallography and NMR. J.Biol.Chem., 276, 2001
5W90	FEZ-1 metallo-beta-lactamase from Legionella gormanii modelled with unknown ligand 分子名称: FEZ-1 protein, GLYCEROL, SULFATE ION, ... 著者 Garcia-Saez, I, Mercuri, P.S, Kahn, R, Shabalin, I.G, Raczynska, J.E, Jaskolski, M, Minor, W, Papamicael, C, Frere, J.M, Galleni, M, Dideberg, O. 登録日 2017-06-22 公開日 2018-06-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril. J. Mol. Biol., 325, 2003
8TH9	Structure of mammalian NEIL2 from Monodelphis domestica in complex with THF-containing DNA 分子名称: DIMETHYL SULFOXIDE, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3'), ... 著者 Eckenroth, B.E, Doublie, S. 登録日 2023-07-14 公開日 2023-11-01 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structural and biochemical insights into NEIL2's preference for abasic sites. Nucleic Acids Res., 51, 2023
8TAZ	Cryo-EM structure of mink variant Y453F trimeric spike protein bound to one mink ACE2 receptors 分子名称: Angiotensin-converting enzyme, Spike glycoprotein 著者 Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Liang, B. 登録日 2023-06-28 公開日 2023-10-25 実験手法 ELECTRON MICROSCOPY (3.75 Å) 主引用文献 Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
8T25	Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at downRBD conformation. 分子名称: Angiotensin-converting enzyme, Spike glycoprotein 著者 Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. 登録日 2023-06-05 公開日 2023-10-25 実験手法 ELECTRON MICROSCOPY (3.62 Å) 主引用文献 Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
8T21	Cryo-EM structure of mink variant Y453F trimeric spike protein 分子名称: Spike glycoprotein 著者 Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. 登録日 2023-06-05 公開日 2023-10-25 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
5WRV	Complex structure of human SRP72/SRP68 分子名称: ACETATE ION, GLYCEROL, SODIUM ION, ... 著者 Gao, Y, Chen, Z. 登録日 2016-12-04 公開日 2017-06-21 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation J Mol Cell Biol, 9, 2017
8T22	Cryo-EM structure of mink variant Y453F trimeric spike protein bound to one mink ACE2 receptors at downRBD conformation 分子名称: Angiotensin-converting enzyme, Spike glycoprotein 著者 Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. 登録日 2023-06-05 公開日 2023-10-25 実験手法 ELECTRON MICROSCOPY (3.83 Å) 主引用文献 Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
8T20	Cryo-EM structure of mink variant Y453F trimeric spike protein bound to two mink ACE2 receptors 分子名称: Angiotensin-converting enzyme, Spike glycoprotein 著者 Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. 登録日 2023-06-05 公開日 2023-10-25 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
8T23	Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at upRBD conformation 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... 著者 Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. 登録日 2023-06-05 公開日 2023-10-25 実験手法 ELECTRON MICROSCOPY (3.87 Å) 主引用文献 Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
5HQ2	Structural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core particle 分子名称: DNA (149-MER), Guanine nucleotide exchange factor SRM1, Histone H2A, ... 著者 Tavarekere, G, McGinty, R.K, Tan, S. 登録日 2016-01-21 公開日 2016-03-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate. J.Mol.Biol., 428, 2016
8SYJ	Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Iodide crystal form) 分子名称: GLYCEROL, IODIDE ION, SULFATE ION, ... 著者 Eckenroth, B.E, Gardner, A.F, Doublie, S. 登録日 2023-05-25 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem., 300, 2023
8SPC	Crystal structure of the cytochrome P450 enzyme RufO 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Cytochrome P450, ... 著者 Dratch, B.D, Davis, K.M. 登録日 2023-05-02 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.871 Å) 主引用文献 Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO. Acs Chem.Biol., 18, 2023
5WCK	Native FEZ-1 metallo-beta-lactamase from Legionella gormanii 分子名称: FEZ-1 protein, GLYCEROL, SULFATE ION, ... 著者 Garcia-Saez, I, Mercuri, P.S, Kahn, R, Papamicael, C, Shabalin, I.G, Raczynska, J.E, Jaskolski, M, Minor, W, Frere, J.M, Galleni, M, Dideberg, O. 登録日 2017-06-30 公開日 2018-06-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril. J. Mol. Biol., 325, 2003
8TUI	Crystal structure of Fab-Lirilumab bound to KIR2DL3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Killer cell immunoglobulin-like receptor 2DL3, Lirilumab Fab Heavy Chain, ... 著者 Lorig-Roach, N, DuBois, R.M. 登録日 2023-08-16 公開日 2023-12-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural basis for the activity and specificity of the immune checkpoint inhibitor lirilumab. Sci Rep, 14, 2024
4UFR	Structure of the ectodomain of LGR5 in complex with R-spondin-2 (Fu1Fu2) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5, ... 著者 Zebisch, M, Jones, E.Y. 登録日 2015-03-18 公開日 2015-07-08 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of R-Spondin 2 in Complex with the Ectodomains of its Receptors Lgr5 and Znrf3. J.Struct.Biol., 191, 2015
8SKQ	RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA) 分子名称: TNA-containing RNA oligonucleotide 著者 Harp, J.M, Egli, M. 登録日 2023-04-20 公開日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. J.Am.Chem.Soc., 145, 2023
8T1H	Cryo-EM structure of a full-length, native Drp1 dimer 分子名称: Dynamin-1-like protein 著者 Rochon, K, Mears, J.A. 登録日 2023-06-02 公開日 2024-02-21 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (5.97 Å) 主引用文献 Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1. Nat Commun, 15, 2024
5WBX	Structural insights into the potency of SK/IK channel positive modulators 分子名称: (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin-1, ... 著者 Nam, Y.W, Zhang, M. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights into the potency of SK channel positive modulators. Sci Rep, 7, 2017
5WC5	Structural insights into the potency of SK/IK channel positive modulators 分子名称: 7-fluoro-3-(hydroxyamino)-2H-indol-2-one, CALCIUM ION, Calmodulin-1, ... 著者 Nam, Y.W, Zhang, M. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural insights into the potency of SK channel positive modulators. Sci Rep, 7, 2017
2REN	STRUCTURE OF RECOMBINANT HUMAN RENIN, A TARGET FOR CARDIOVASCULAR-ACTIVE DRUGS, AT 2.5 ANGSTROMS RESOLUTION 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, RENIN 著者 Sielecki, A.R, James, M.N.G. 登録日 1992-02-05 公開日 1994-01-31 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution. Science, 243, 1989
1EKJ	THE X-RAY CRYSTALLOGRAPHIC STRUCTURE OF BETA CARBONIC ANHYDRASE FROM THE C3 DICOT PISUM SATIVUM 分子名称: 1,2-ETHANEDIOL, ACETATE ION, AZIDE ION, ... 著者 Kimber, M.S, Pai, E.F. 登録日 2000-03-08 公開日 2000-06-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases. EMBO J., 19, 2000
5WQJ	Crystal structure of 3-Mercaptopyruvate Sulfurtransferase(3MST) in complex with compound1 分子名称: 2-[2-[(4-oxidanylidene-3~{H}-quinazolin-2-yl)sulfanyl]ethanoylamino]thiophene-3-carboxamide, SODIUM ION, Sulfurtransferase 著者 Suwanai, Y, Toma-Fukai, S, Shimizu, T. 登録日 2016-11-27 公開日 2017-09-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide Sci Rep, 7, 2017

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