PDB: 66507 件ウェブページステータス検索Chemie searchBIRD

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6SB0	cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... 著者 Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. 登録日 2019-07-18 公開日 2019-10-16 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (5.5 Å) 主引用文献 Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
6VAA	Structure of the Fanconi Anemia ID complex bound to ICL DNA 分子名称: DNA (26-MER), DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), ... 著者 Pavletich, N.P. 登録日 2019-12-17 公開日 2020-03-18 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex. Nature, 580, 2020
6SLR	Structure of saposin B in complex with atovaquone 分子名称: 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione, GLYCEROL, Prosaposin 著者 Zubieta, C, Milliken, B, Doyle, R. 登録日 2019-08-20 公開日 2020-09-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Structure of saposin B in complex with atovaquone To Be Published
6SK1	Diaminobutyrate acetyltransferase EctA from Paenibacillus lautus in complex with coenzyme A 分子名称: ACETATE ION, COENZYME A, L-2,4-diaminobutyric acid acetyltransferase 著者 Richter, A.A, Kobus, S, Czech, L, Hoeppner, A, Bremer, E, Smits, S.H.J. 登録日 2019-08-14 公開日 2020-01-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The architecture of the diaminobutyrate acetyltransferase active site provides mechanistic insight into the biosynthesis of the chemical chaperone ectoine. J.Biol.Chem., 295, 2020
4HSQ	Crystal Structure of Domains D2 and D3 of the Major Pilin SpaD from Corynebacterium diphtheriae 分子名称: CALCIUM ION, Putative fimbrial subunit 著者 Paterson, N.G, Kang, H.J, Baker, E.N. 登録日 2012-10-30 公開日 2013-11-13 最終更新日 2014-06-25 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 A slow-forming isopeptide bond in the structure of the major pilin SpaD from Corynebacterium diphtheriae has implications for pilus assembly. Acta Crystallogr.,Sect.D, 70, 2014
6VAF	Structure of mono-ubiquitinated FANCD2 bound to non-ubiquitinated FANCI and to DNA 分子名称: DNA (29-MER), Fanconi anemia group D2 protein, Fanconi anemia, ... 著者 Pavletich, N.P. 登録日 2019-12-17 公開日 2020-03-18 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex. Nature, 580, 2020
4I33	Crystal structure of HCV NS3/4A R155K protease complexed with compound 4 分子名称: (2R,6S,7E,10E,13aR,14aR,16aS)-2-{[7-methoxy-8-methyl-2-(propan-2-yloxy)quinolin-4-yl]oxy}-N-[(1-methylcyclopropyl)sulfonyl]-6-{[(1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-5,16-dioxo-1,2,3,6,9,12,13,13a,14,15,16,16a-dodecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide, Genome polyprotein, HCV non-structural protein 4A, ... 著者 Lemke, C.T. 登録日 2012-11-23 公開日 2013-01-02 最終更新日 2013-03-13 実験手法 X-RAY DIFFRACTION (1.9001 Å) 主引用文献 Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance. J.Biol.Chem., 288, 2013
6SBI	X-ray structure of murine Fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) in complex with inhibitor oxalate 分子名称: Acylpyruvase FAHD1, mitochondrial, CHLORIDE ION, ... 著者 Rupp, B, Naschberger, A, Weiss, A.K.H. 登録日 2019-07-21 公開日 2020-03-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse. Biosci.Rep., 40, 2020
6SCF	A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic oligoadenylate 分子名称: Uncharacterized protein, cyclic oligoadenylate 著者 McMahon, S.A, Athukoralage, J.S, Graham, S, White, M.F, Gloster, T.M. 登録日 2019-07-24 公開日 2019-10-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity. Nature, 577, 2020
6PED	Crystal structure of HEMK2-TRMT112 complex 分子名称: Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2019-06-20 公開日 2019-07-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of HEMK2-TRMT112 complex To Be Published
6UX0	Isavuconazole bound complex of Acanthamoeba castellanii CYP51 分子名称: 4-{2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl}benzonitrile, FE (III) ION, Obtusifoliol 14alphademethylase, ... 著者 Sharma, V, Podust, L.M. 登録日 2019-11-06 公開日 2020-10-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole. Mol.Pharmacol., 98, 2020
3IFJ	Crystal structure of Mtu recA intein, splicing domain 分子名称: Endonuclease PI-MtuI, ZINC ION 著者 Van Roey, P, Belfort, M. 登録日 2009-07-24 公開日 2009-10-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Selection and structure of hyperactive inteins: peripheral changes relayed to the catalytic center. J.Mol.Biol., 393, 2009
6PBA	Structure of ClpC1-NTD 分子名称: ATP-dependent Clp protease ATP-binding subunit ClpC1 著者 Abad-Zapatero, C, Wolf, N.M. 登録日 2019-06-13 公開日 2020-05-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions. Acta Crystallogr D Struct Biol, 76, 2020
6SLS	Flavin-dependent tryptophan 6-halogenase Thal in complex with FAD 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PHOSPHATE ION, ... 著者 Moritzer, A, Niemann, H.H. 登録日 2019-08-20 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal is negatively coupled. Protein Sci., 28, 2019
4I31	Crystal structure of HCV NS3/NS4A protease complexed with compound 4 分子名称: (2R,6S,7E,10E,13aR,14aR,16aS)-2-{[7-methoxy-8-methyl-2-(propan-2-yloxy)quinolin-4-yl]oxy}-N-[(1-methylcyclopropyl)sulfonyl]-6-{[(1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-5,16-dioxo-1,2,3,6,9,12,13,13a,14,15,16,16a-dodecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide, Genome polyprotein, HCV non-structural protein 4A, ... 著者 Lemke, C.T. 登録日 2012-11-23 公開日 2013-01-02 最終更新日 2013-03-13 実験手法 X-RAY DIFFRACTION (1.9301 Å) 主引用文献 Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance. J.Biol.Chem., 288, 2013
6SMF	THE CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINASE FROM ZYMOMONAS MOBILIS 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-dehydroquinate dehydratase, CITRATE ANION, ... 著者 Lapthorn, A.J, Roszak, A.W. 登録日 2019-08-21 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.343 Å) 主引用文献 Biomacromolecular charge chirality detected using chiral plasmonic nanostructures Nanoscale Horiz., 2020
6PBQ	Structure of ClpC1-NTD 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ATP-dependent Clp protease ATP-binding subunit ClpC1, PHOSPHATE ION 著者 Abad-Zapatero, C, Wolf, N.M. 登録日 2019-06-14 公開日 2020-05-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions. Acta Crystallogr D Struct Biol, 76, 2020
6SP6	Ultra-high Resolution Crystal Structure of the CTX-M-15 Extended-Spectrum beta-Lactamase in Complex with Taniborbactam (VNRX-5133) 分子名称: (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase, ... 著者 Docquier, J.D, Pozzi, C, De Luca, F, Benvenuti, M, Mangani, S. 登録日 2019-08-31 公開日 2020-01-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-beta-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J.Med.Chem., 63, 2020
6UPU	Crystal structure of the Orientia tsutsugamushi OtDUB in complex with three molecules of ubiquitin 分子名称: ULP_PROTEASE domain-containing protein, Ubiquitin 著者 Lim, C.S, Ronau, J.A, Xiong, Y. 登録日 2019-10-18 公開日 2020-04-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi. Nat Commun, 11, 2020
6PJ9	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane 分子名称: Peptide aldehyde inhibitor, Rhomboid protease GlpG 著者 Urban, S, Cho, S. 登録日 2019-06-28 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
4IAC	X-RAY structure of cAMP dependent protein kinase A in complex with HIGH MG2+ concentration, AMP-PCP AND pseudo-substrate peptide SP20 分子名称: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Peptide SP20, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-06 公開日 2013-06-12 最終更新日 2016-09-21 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
3WI0	P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1) 分子名称: Polymerase basic protein 2 著者 Tsurumura, T, Yoshida, T, Tsuge, H. 登録日 2013-09-04 公開日 2013-12-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 Conformational Polymorphism of m7GTP in Crystal Structure of the PB2 Middle Domain from Human Influenza A Virus Plos One, 8, 2013
4IAI	X-ray Structure of cAMP dependent protein kinase A in complex with high Ca2+ concentration, ADP and phosphorylated peptide pSP20 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CARBONATE ION, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-06 公開日 2013-06-12 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4IB3	Structure of cAMP dependent protein kinase A in complex with ADP, phosphorylated peptide pSP20, and no metal 分子名称: ADENOSINE-5'-DIPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, phosphorylated pseudo-substrate peptide pSP20 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-07 公開日 2013-12-11 最終更新日 2014-05-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
6PL9	Adduct formed after 1 month in the reaction of dichlorido(1,3-dimethylbenzimidaz ol-2-ylidene)(eta5-pentamethylcyclopentadienyl)rhodium(III) with HEWL 分子名称: 2-(1-chloranyl-2,3,4,5,6-pentamethyl-1$l^{7}-rhodapentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexan-1-yl)-1,3-dimethyl-benzimidazole, Lysozyme, SODIUM ION, ... 著者 Sullivan, M.P, Hartinger, C.G, Goldstone, D.C. 登録日 2019-06-30 公開日 2020-11-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Probing the Paradigm of Promiscuity for N-Heterocyclic Carbene Complexes and their Protein Adduct Formation. Angew.Chem.Int.Ed.Engl., 2021

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