PDB: 71589 件ウェブページステータス検索Chemie searchBIRD

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2EWY	Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor 分子名称: Beta-secretase 2, N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHYLBENZYL)AMINO]PROPYL}DIBENZO[B,F]OXEPINE-10-CARBOXAMIDE 著者 Ostermann, N. 登録日 2005-11-07 公開日 2006-11-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of human BACE2 in complex with a hydroxyethylamine transition state inhibitor J.Mol.Biol., 355, 2006
5HWJ	Crystal structure of keto-deoxy-D-galactarate dehydratase 分子名称: FORMIC ACID, GLYCEROL, Probable 5-dehydro-4-deoxyglucarate dehydratase 著者 Taberman, H, Parkkinen, T, Hakulinen, N, Rouvinen, J. 登録日 2016-01-29 公開日 2016-03-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.648 Å) 主引用文献 Structure and function of a decarboxylating Agrobacterium tumefaciens keto-deoxy-d-galactarate dehydratase. Biochemistry, 53, 2014
2ZEV	S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium, IPP and BPH-715 分子名称: 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, ... 著者 Guo, R.T, Chen, C.K.-M, Cao, R, Oldfield, E, Wang, A.H.-J. 登録日 2007-12-17 公開日 2008-12-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation J.Am.Chem.Soc., 131, 2009
3CA0	Sambucus nigra agglutinin II (SNA-II), hexagonal crystal form 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Agglutinin II, ... 著者 Maveyraud, L, Niwa, H, Guillet, V, Palmer, R.A, Reynolds, C.D, Mourey, L. 登録日 2008-02-19 公開日 2008-11-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra Proteins, 75, 2009
2D5H	Crystal Structure of Recombinant Soybean Proglycinin A3B4 subunit, its Comparison with Mature Glycinin A3B4 subunit, Responsible for Hexamer Assembly 分子名称: CARBONATE ION, MAGNESIUM ION, glycinin A3B4 subunit 著者 Itoh, T, Adachi, M, Masuda, T, Mikami, B, Utsumi, S. 登録日 2005-11-01 公開日 2006-11-14 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Conservation and divergence on plant seed 11S globulins based on crystal structures. Biochim.Biophys.Acta, 2010
2D4M	Crystal Structure of apo M-PMV dUTPase 分子名称: DU 著者 Nemeth, V, Barabas, O, Vertessy, G.B. 登録日 2005-10-20 公開日 2006-11-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins. Nucleic Acids Res., 35, 2007
3C7X	Hemopexin-like domain of matrix metalloproteinase 14 分子名称: CHLORIDE ION, Matrix metalloproteinase-14, SODIUM ION 著者 Tochowicz, A, Itoh, Y, Maskos, K, Bode, W, Goettig, P. 登録日 2008-02-08 公開日 2009-02-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions J.Biol.Chem., 286, 2011
3CA5	Crystal structure of Sambucus nigra agglutinin II (SNA-II)-tetragonal crystal form- complexed to alpha1 methylgalactose 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Maveyraud, L, Mourey, L. 登録日 2008-02-19 公開日 2008-11-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra Proteins, 75, 2009
5HNI	CRYSTAL STRUCTURE OF CMET WT with compound 3 分子名称: Hepatocyte growth factor receptor, methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1H-benzimidazol-2-yl)carbamate 著者 Vallee, F, Houtmann, J. 登録日 2016-01-18 公開日 2016-11-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
5HO6	CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH CMPD. 分子名称: 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea, Hepatocyte growth factor receptor 著者 Vallee, F, Houtmann, J. 登録日 2016-01-19 公開日 2016-11-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
2D4L	Crystal structure of truncated in C-terminal M-PMV dUTPase 分子名称: DU 著者 Nemeth, V, Barabas, O, Vertessy, G.B. 登録日 2005-10-20 公開日 2006-11-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins. Nucleic Acids Res., 35, 2007
3CAH	Sambucus nigra aggutinin II. tetragonal crystal form- complexed to fucose 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Maveyraud, L, Mourey, L. 登録日 2008-02-20 公開日 2008-11-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra Proteins, 75, 2009
5HEZ	JAK2 kinase (JH1 domain) mutant P1057A in complex with TG101209 分子名称: CHLORIDE ION, N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide, Tyrosine-protein kinase JAK2, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2016-01-06 公開日 2016-11-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Sci Transl Med, 8, 2016
2FH3	C-terminal half of gelsolin soaked in low calcium at pH 8 分子名称: CALCIUM ION, Gelsolin 著者 Chumnarnsilpa, S, Loonchanta, A, Xue, B, Choe, H, Urosev, D, Wang, H, Burtnick, L.D, Robinson, R.C. 登録日 2005-12-23 公開日 2006-06-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.87 Å) 主引用文献 Calcium ion exchange in crystalline gelsolin J.Mol.Biol., 357, 2006
2F7E	PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine 分子名称: (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE, PKI inhibitory peptide, cAMP-dependent protein kinase, ... 著者 Stoll, V.S. 登録日 2005-11-30 公開日 2006-06-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg.Med.Chem.Lett., 16, 2006
3CA1	Sambucus nigra agglutinin II (SNA-II)- tetragonal crystal form- complexed to galactose 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Maveyraud, L, Mourey, L. 登録日 2008-02-19 公開日 2008-11-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra Proteins, 75, 2009
3C9Z	Sambucus nigra agglutinin II (SNA-II), tetragonal crystal form 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Maveyraud, L, Guillet, V, Mourey, L. 登録日 2008-02-19 公開日 2008-11-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra Proteins, 75, 2009
3CDE	Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor 分子名称: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2008-02-26 公開日 2009-03-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg.Med.Chem.Lett., 18, 2008
2DOR	DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS COMPLEXED WITH OROTATE 分子名称: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, OROTIC ACID 著者 Rowland, P, Larsen, S. 登録日 1998-05-11 公開日 1998-08-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function. Protein Sci., 7, 1998
3CUV	Tracking structure activity relationships of glycogen phosphorylase inhibitors: synthesis, kinetic and crystallographic evaluation of analogues of N-(-D-glucopyranosyl)-N'-oxamides 分子名称: DIMETHYL SULFOXIDE, Glycogen phosphorylase, muscle form, ... 著者 Kyritsi, C, Chrysina, E.D, Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G. 登録日 2008-04-17 公開日 2009-04-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Tracking structure activity relationships of glycogen phosphorylase inhibitors: synthesis, kinetic and crystallographic evaluation of analogues of N-(-D-glucopyranosyl)-N'-oxamides To be Published
3CVZ	Structural insights into the molecular organization of the S-layer from Clostridium difficile 分子名称: GLYCINE, PHOSPHATE ION, S-layer protein 著者 Albesa-Jove, D, Fagan, R. 登録日 2008-04-20 公開日 2009-03-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural insights into the molecular organization of the S-layer from Clostridium difficile Mol.Microbiol., 71, 2009
2FH2	C-terminal half of gelsolin soaked in EGTA at pH 4.5 分子名称: CALCIUM ION, Gelsolin 著者 Chumnarnsilpa, S, Loonchanta, A, Xue, B, Choe, H, Urosev, D, Wang, H, Burtnick, L.D, Robinson, R.C. 登録日 2005-12-23 公開日 2006-06-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Calcium ion exchange in crystalline gelsolin J.Mol.Biol., 357, 2006
2ORO	Murine inducible nitric oxide synthase oxygenase domain (delta 114) (r)-1-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-pyrrolidine-2-carboxylic acid (2-benzo[1,3]dioxol-5-yl-ethyl)-amide complex 分子名称: N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE, PROTOPORPHYRIN IX CONTAINING FE, SULFITE ION, ... 著者 Adler, M, Whitlow, M. 登録日 2007-02-04 公開日 2007-04-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors J.Med.Chem., 50, 2007
2CUT	CUTINASE, A LIPOLYTIC ENZYME WITH A PREFORMED OXYANION HOLE 分子名称: CUTINASE, DIETHYL PHOSPHONATE 著者 Martinez, C, Cambillau, C. 登録日 1994-06-03 公開日 1994-08-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Cutinase, a lipolytic enzyme with a preformed oxyanion hole. Biochemistry, 33, 1994
3CUW	Crystal structure of glycogen phosphorylase b in complex with N-(-D-glucopyranosyl)-N'-(2-naphthyl)oxamides 分子名称: Glycogen phosphorylase, muscle form, N-[oxo(phenylamino)acetyl]-beta-D-glucopyranosylamine 著者 Kyritsi, C, Chrysina, E.D, Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G. 登録日 2008-04-17 公開日 2009-04-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Tracking structure activity relationships of glycogen phosphorylase inhibitors: synthesis, kinetic and crystallographic evaluation of analogues of N-(-D-glucopyranosyl)-N'-oxamides To be Published

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