3CUV

Tracking structure activity relationships of glycogen phosphorylase inhibitors: synthesis, kinetic and crystallographic evaluation of analogues of N-(-D-glucopyranosyl)-N'-oxamides

Summary for 3CUV

• Entry DOI: 10.2210/pdb3cuv/pdb
• Related: 3CUT 3CUU 3CUW
• Descriptor: Glycogen phosphorylase, muscle form, N-[oxo(pyridin-2-ylamino)acetyl]-beta-D-glucopyranosylamine, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: glycogen phosphorylase, catalytic site, rational inhibitor design, acetylation, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 99018.60

Authors

Kyritsi, C.,Chrysina, E.D.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G. (deposition date: 2008-04-17, release date: 2009-04-21, Last modification date: 2023-11-15)

• Primary citation: Czifrak, K.,Kyritsi, C.,Felfoldi, N.,Dosca, T.,Gergely, P.,Chrysina, E.D.,Siafaka-Kapadai, A.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.; Tracking structure activity relationships of glycogen phosphorylase inhibitors: synthesis, kinetic and crystallographic evaluation of analogues of N-(-D-glucopyranosyl)-N'-oxamides; To be Published,

Experimental method

X-RAY DIFFRACTION (1.93 Å)