2EWY

Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor

Summary for 2EWY

Entry DOI	10.2210/pdb2ewy/pdb
Descriptor	Beta-secretase 2, N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHYLBENZYL)AMINO]PROPYL}DIBENZO[B,F]OXEPINE-10-CARBOXAMIDE (3 entities in total)
Functional Keywords	bace2, aspartic protease, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: Q9Y5Z0
Total number of polymer chains	4
Total formula weight	169110.63
Authors	Ostermann, N. (deposition date: 2005-11-07, release date: 2006-11-07, Last modification date: 2023-08-23)
Primary citation	Ostermann, N.,Eder, J.,Eidhoff, U.,Zink, F.,Hassiepen, U.,Worpenberg, S.,Maibaum, J.,Simic, O.,Hommel, U.,Gerhartz, B. Crystal structure of human BACE2 in complex with a hydroxyethylamine transition state inhibitor J.Mol.Biol., 355:249-261, 2006 Cited by PubMed: 16305800 DOI: 10.1016/j.jmb.2005.10.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation