2EWY

Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0016020	cellular_component	membrane
C	0004190	molecular_function	aspartic-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0016020	cellular_component	membrane
D	0004190	molecular_function	aspartic-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DBO A 1001

Chain	Residue
A	LEU46
A	TRP131
A	TYR211
A	ASP241
A	GLY243
A	THR244
A	THR245
A	ARG248
B	GLY326
B	LEU327
A	ASP48
A	GLY50
A	SER51
A	LYS86
A	TYR87
A	THR88
A	GLN89
A	PHE124

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DBO B 1002

Chain	Residue
A	GLY326
A	LEU327
B	LEU46
B	ASP48
B	GLY50
B	SER51
B	LYS86
B	TYR87
B	THR88
B	GLN89
B	PHE124
B	TRP131
B	TYR211
B	ASP241
B	GLY243
B	THR244
B	THR245
B	ARG248

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DBO C 1003

Chain	Residue
C	LEU46
C	ASP48
C	GLY50
C	SER51
C	LYS86
C	TYR87
C	THR88
C	GLN89
C	PHE124
C	TRP131
C	TYR211
C	ASP241
C	GLY243
C	THR244
C	THR245
C	ARG248
D	GLY326
D	LEU327

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DBO D 1004

Chain	Residue
C	GLY326
C	LEU327
D	LEU46
D	ASP48
D	GLY50
D	SER51
D	LYS86
D	TYR87
D	THR88
D	GLN89
D	PHE124
D	TRP131
D	TYR211
D	ASP241
D	GLY243
D	THR244
D	THR245
D	ARG248

---

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV

Chain	Residue	Details
A	ILE45-VAL56
A	ALA238-LEU249

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	ASP48
A	SER51
A	ASP241
A	THR244

---

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	ASP48
B	SER51
B	ASP241

---

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP48
C	SER51
C	ASP241

---

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	ASP48
D	SER51
D	ASP241

---

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	ASP48
A	SER51
A	TYR87
A	ASP241

---

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	ASP48
B	SER51
B	TYR87
B	ASP241

---

site_id	CSA15
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP48
C	SER51
C	TYR87
C	ASP241

---

site_id	CSA16
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	ASP48
D	SER51
D	TYR87
D	ASP241

---

site_id	CSA17
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	ASP48
A	THR49
A	ASP241
A	THR244

---

site_id	CSA18
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	ASP48
B	THR49
B	ASP241
B	THR244

---

site_id	CSA19
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP48
C	THR49
C	ASP241
C	THR244

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	ASP48
B	SER51
B	ASP241
B	THR244

---

site_id	CSA20
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	ASP48
D	THR49
D	ASP241
D	THR244

---

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	ASP48
A	ASP241

---

site_id	CSA22
Number of Residues	2
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	ASP48
B	ASP241

---

site_id	CSA23
Number of Residues	2
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP48
C	ASP241

---

site_id	CSA24
Number of Residues	2
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	ASP48
D	ASP241

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP48
C	SER51
C	ASP241
C	THR244

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	ASP48
D	SER51
D	ASP241
D	THR244

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	SER242
A	ASP48
A	THR49
A	ASP241

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
B	SER242
B	ASP48
B	THR49
B	ASP241

---

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	SER242
C	ASP48
C	THR49
C	ASP241

---

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
D	SER242
D	ASP48
D	THR49
D	ASP241

---

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
A	ASP48
A	SER51
A	ASP241

---