2EWY
Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Beta-secretase 2 | polymer | 383 | 41773.0 | 4 | UniProt (Q9Y5Z0) Pfam (PF00026) | Homo sapiens (human) | Beta-site APP-cleaving enzyme 2, Aspartyl protease 1, Asp 1, ASP1, Membrane-associated aspartic protease 1, Memapsin-1, Down region aspartic protease |
| 2 | E, F, G, H (A, B, C, D) | N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHYLBENZYL)AMINO]PROPYL}DIBENZO[B,F]OXEPINE-10-CARBOXAMIDE | non-polymer | 504.6 | 4 | Chemie (DBO) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 167092.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2018.5 | |
| All* | Total formula weight | 169110.6 |
