2ORO
Murine inducible nitric oxide synthase oxygenase domain (delta 114) (r)-1-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-pyrrolidine-2-carboxylic acid (2-benzo[1,3]dioxol-5-yl-ethyl)-amide complex
Summary for 2ORO
Entry DOI | 10.2210/pdb2oro/pdb |
Related | 1DD7 1NOC 1NOD 1NOS 1NSI 2NOS 2ORP 2ORQ 2ORR 2ORS 2ORT |
Descriptor | nitric oxide synthase, inducible, SULFITE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total) |
Functional Keywords | nitric oxide; l-arginine monooxygenase; heme; dimerization; inhibitor; nos, oxidoreductase |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 1 |
Total formula weight | 46387.39 |
Authors | Adler, M.,Whitlow, M. (deposition date: 2007-02-04, release date: 2007-04-10, Last modification date: 2023-08-30) |
Primary citation | Davey, D.D.,Adler, M.,Arnaiz, D.,Eagen, K.,Erickson, S.,Guilford, W.,Kenrick, M.,Morrissey, M.M.,Ohlmeyer, M.,Pan, G.,Paradkar, V.M.,Parkinson, J.,Polokoff, M.,Saionz, K.,Santos, C.,Subramanyam, B.,Vergona, R.,Wei, R.G.,Whitlow, M.,Ye, B.,Zhao, Z.S.,Devlin, J.J.,Phillips, G. Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors J.Med.Chem., 50:1146-1157, 2007 Cited by PubMed: 17315988DOI: 10.1021/jm061319i PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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