4EH2
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![BU of 4eh2 by Molmil](/molmil-images/mine/4eh2) | Human p38 MAP kinase in complex with NP-F1 and RL87 | 分子名称: | 3-phenylquinazolin-4(3H)-one, Mitogen-activated protein kinase 14, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine | 著者 | Over, B, Gruetter, C, Waldmann, H, Rauh, D. | 登録日 | 2012-04-02 | 公開日 | 2012-12-05 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem, 5, 2012
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7KVI
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![BU of 7kvi by Molmil](/molmil-images/mine/7kvi) | Human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Sevrioukova, I. | 登録日 | 2020-11-28 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength. Int J Mol Sci, 22, 2021
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6K5M
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![BU of 6k5m by Molmil](/molmil-images/mine/6k5m) | The crystal structure of a serotonin N-acetyltransferase from Oryza Sativa (Rice) | 分子名称: | Serotonin N-acetyltransferase 1, chloroplastic | 著者 | Zhou, Y.Z, Liao, L.J, Liu, X.K, Guo, Y, Zhao, Y.C, Zeng, Z.X. | 登録日 | 2019-05-29 | 公開日 | 2020-06-03 | 最終更新日 | 2021-09-22 | 実験手法 | X-RAY DIFFRACTION (1.793 Å) | 主引用文献 | Structural and Molecular Dynamics Analysis of Plant Serotonin N-Acetyltransferase Reveal an Acid/Base-Assisted Catalysis in Melatonin Biosynthesis. Angew.Chem.Int.Ed.Engl., 60, 2021
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6K5R
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![BU of 6k5r by Molmil](/molmil-images/mine/6k5r) | Complex of SUMO2 with Phosphorylated viral SIM IE2 | 分子名称: | ASP-THR-ALA-GLY-CYS-ILE-VAL-ILE-SEP-ASP-SEP-GLU, Small ubiquitin-related modifier 3 | 著者 | Chatterjee, K.S, Das, R. | 登録日 | 2019-05-30 | 公開日 | 2019-08-07 | 最終更新日 | 2019-12-25 | 実験手法 | SOLUTION NMR | 主引用文献 | Casein kinase-2-mediated phosphorylation increases the SUMO-dependent activity of the cytomegalovirus transactivator IE2. J.Biol.Chem., 294, 2019
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7KVJ
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![BU of 7kvj by Molmil](/molmil-images/mine/7kvj) | Human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-{[(2S)-1-oxo-3-phenyl-1-{[3-(pyridin-3-yl)propyl]amino}propan-2-yl]sulfanyl}-3-phenylpropan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2020-11-28 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength. Int J Mol Sci, 22, 2021
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7KVQ
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![BU of 7kvq by Molmil](/molmil-images/mine/7kvq) | Human CYP3A4 bound to an inhibitor | 分子名称: | 1,2-ETHANEDIOL, Cytochrome P450 3A4, GLYCEROL, ... | 著者 | Sevrioukova, I. | 登録日 | 2020-11-28 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength. Int J Mol Sci, 22, 2021
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7KVS
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![BU of 7kvs by Molmil](/molmil-images/mine/7kvs) | Human CYP3A4 bound to an inhibitor | 分子名称: | 1,2-ETHANEDIOL, Cytochrome P450 3A4, GLYCEROL, ... | 著者 | Sevrioukova, I. | 登録日 | 2020-11-28 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength. Int J Mol Sci, 22, 2021
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4BJT
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![BU of 4bjt by Molmil](/molmil-images/mine/4bjt) | Crystal structure of the Rap1 C-terminal domain (Rap1-RCT) in complex with the Rap1 binding module of Rif1 (Rif1-RBM) | 分子名称: | 1,2-ETHANEDIOL, DNA-BINDING PROTEIN RAP1, TELOMERE LENGTH REGULATOR PROTEIN RIF1 | 著者 | Shi, T, Bunker, R.D, Gut, H, Scrima, A, Thoma, N.H. | 登録日 | 2013-04-19 | 公開日 | 2013-06-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Rif1 and Rif2 Shape Telomere Funcation and Architecture Through Multivalent RAP1 Interactions Cell(Cambridge,Mass.), 153, 2013
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4BL7
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![BU of 4bl7 by Molmil](/molmil-images/mine/4bl7) | |
6JWJ
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![BU of 6jwj by Molmil](/molmil-images/mine/6jwj) | Npl4 in complex with Ufd1 | 分子名称: | GLYCEROL, Nuclear protein localization protein 4, Peptide from Ubiquitin fusion degradation protein 1, ... | 著者 | Sato, Y, Fukai, S. | 登録日 | 2019-04-20 | 公開日 | 2019-12-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4. Nat Commun, 10, 2019
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7KVN
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![BU of 7kvn by Molmil](/molmil-images/mine/7kvn) | Human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-(1H-indol-3-yl)-3-{[(2R)-1-oxo-3-phenyl-1-{[3-(pyridin-3-yl)propyl]amino}propan-2-yl]sulfanyl}propan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2020-11-28 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength. Int J Mol Sci, 22, 2021
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4JGC
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![BU of 4jgc by Molmil](/molmil-images/mine/4jgc) | Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC) | 分子名称: | 4-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid, G/T mismatch-specific thymine DNA glycosylase, oligonucleotide, ... | 著者 | Hashimoto, H, Zhang, X, Cheng, X. | 登録日 | 2013-02-28 | 公開日 | 2013-05-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.582 Å) | 主引用文献 | Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. Dna Repair, 12, 2013
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5WX9
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![BU of 5wx9 by Molmil](/molmil-images/mine/5wx9) | Crystal Structure of AtERF96 with GCC-box | 分子名称: | Ethylene-responsive transcription factor ERF096, GCC-box motif | 著者 | Chen, C.Y, Cheng, Y.S. | 登録日 | 2017-01-06 | 公開日 | 2017-11-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural insights into Arabidopsis ethylene response factor 96 with an extended N-terminal binding to GCC box. Plant Mol.Biol., 104, 2020
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7LXL
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![BU of 7lxl by Molmil](/molmil-images/mine/7lxl) | Crystal structure of human CYP3A4 bound to the testosterone dimer | 分子名称: | 17alpha-hydroxy-7alpha-[(2Z)-4-(17beta-hydroxy-3-oxo-8alpha-androst-4-en-7beta-yl)but-2-en-1-yl]-8alpha,10alpha,13alpha,14beta-androst-4-en-3-one, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sevrioukova, I.F. | 登録日 | 2021-03-04 | 公開日 | 2021-04-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Innovative C 2 -symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4. Eur.J.Med.Chem., 220, 2021
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6K4S
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![BU of 6k4s by Molmil](/molmil-images/mine/6k4s) | Crystal structure of xCas9 in complex with sgRNA and DNA (TGC PAM) | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, non-targeted DNA, sgRNA, ... | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | 登録日 | 2019-05-26 | 公開日 | 2019-09-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease. Plos Biol., 17, 2019
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7LK3
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![BU of 7lk3 by Molmil](/molmil-images/mine/7lk3) | Crystal structure of untwinned human GABARAPL2 | 分子名称: | 1,2-ETHANEDIOL, Gamma-aminobutyric acid receptor-associated protein-like 2 | 著者 | Scicluna, K, Dewson, G, Czabotar, P.E, Birkinshaw, R.W. | 登録日 | 2021-02-01 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A new crystal form of GABARAPL2. Acta Crystallogr.,Sect.F, 77, 2021
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2EZ6
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![BU of 2ez6 by Molmil](/molmil-images/mine/2ez6) | Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing | 分子名称: | 28-MER, MAGNESIUM ION, Ribonuclease III | 著者 | Gan, J, Tropea, J.E, Austin, B.P, Court, D.L, Waugh, D.S, Ji, X. | 登録日 | 2005-11-10 | 公開日 | 2006-02-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III. Cell(Cambridge,Mass.), 124, 2006
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4BUE
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![BU of 4bue by Molmil](/molmil-images/mine/4bue) | Crystal structure of human tankyrase 2 in complex with 3-methyl-N-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)butanamide | 分子名称: | 3-METHYL-N-[4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PHENYL)BUTANAMIDE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-20 | 公開日 | 2013-10-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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7M10
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![BU of 7m10 by Molmil](/molmil-images/mine/7m10) | |
4BUT
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![BU of 4but by Molmil](/molmil-images/mine/4but) | Crystal structure of human tankyrase 2 in complex with 4-(4-oxo-3,4- dihydroquinazolin-2-yl)benzene-1-sulfonamide | 分子名称: | 4-(4-oxidanylidene-3H-quinazolin-2-yl)benzenesulfonamide, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-24 | 公開日 | 2013-10-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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2PON
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![BU of 2pon by Molmil](/molmil-images/mine/2pon) | Solution structure of the Bcl-xL/Beclin-1 complex | 分子名称: | Apoptosis regulator Bcl-X, Beclin-1 | 著者 | Feng, W, Huang, S, Wu, H, Zhang, M. | 登録日 | 2007-04-27 | 公開日 | 2007-09-04 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular Basis of Bcl-xL's Target Recognition Versatility Revealed by the Structure of Bcl-xL in Complex with the BH3 Domain of Beclin-1. J.Mol.Biol., 372, 2007
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4BU6
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![BU of 4bu6 by Molmil](/molmil-images/mine/4bu6) | Crystal structure of human tankyrase 2 in complex with 2-(4- aminophenyl)-3,4-dihydroquinazolin-4-one | 分子名称: | 2-(4-aminophenyl)-3,4-dihydroquinazolin-4-one, GLYCEROL, SULFATE ION, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-20 | 公開日 | 2013-10-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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4BU5
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![BU of 4bu5 by Molmil](/molmil-images/mine/4bu5) | Crystal structure of human tankyrase 2 in complex with 2-(4- hydroxyphenyl)-3,4-dihydroquinazolin-4-one | 分子名称: | 2-(4-hydroxyphenyl)-3H-quinazolin-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-20 | 公開日 | 2013-10-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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4BUY
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![BU of 4buy by Molmil](/molmil-images/mine/4buy) | Crystal structure of human tankyrase 2 in complex with 5-methyl-5-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)imidazolidine-2,4-dione | 分子名称: | (5S)-5-methyl-5-[4-(4-oxidanylidene-3H-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Haikarainen, T, Narwal, M, Lehtio, L. | 登録日 | 2013-06-24 | 公開日 | 2013-10-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
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4BVX
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![BU of 4bvx by Molmil](/molmil-images/mine/4bvx) | Crystal structure of the AIMP3-MRS N-terminal domain complex with I3C | 分子名称: | 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1, METHIONINE--TRNA LIGASE, ... | 著者 | Cho, H.Y, Seo, W.W, Cho, H.J, Kang, B.S. | 登録日 | 2013-06-29 | 公開日 | 2014-07-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Assembly of Multi-tRNA Synthetase Complex Via Heterotetrameric Glutathione Transferase-Homology Domains. J.Biol.Chem., 290, 2015
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