4BU6

Crystal structure of human tankyrase 2 in complex with 2-(4- aminophenyl)-3,4-dihydroquinazolin-4-one

Summary for 4BU6

Entry DOI	10.2210/pdb4bu6/pdb
Related	4BU3 4BU5 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY
Descriptor	TANKYRASE-2, ZINC ION, SULFATE ION, ... (6 entities in total)
Functional Keywords	transferase, diphtheria toxin like fold, adp-ribosylation, inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	55681.21
Authors	Haikarainen, T.,Narwal, M.,Lehtio, L. (deposition date: 2013-06-20, release date: 2013-10-30, Last modification date: 2019-02-06)
Primary citation	Haikarainen, T.,Koivunen, J.,Narwal, M.,Venkannagari, H.,Obaji, E.,Joensuu, P.,Pihlajaniemi, T.,Lehtio, L. Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8:1978-, 2013 Cited by PubMed: 24130191 DOI: 10.1002/CMDC.201300337 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation