8SMX
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 2) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN3
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 1) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN2
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c (UbcH5c chemically conjugated to histone H2A) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN7
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 5) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SMW
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 1) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN1
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 6) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SMZ
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (Class 4) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN9
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c with backside ubiquitin (UbcH5c chemically conjugated to histone H2A) (class 1) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN6
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 4) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN0
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 5) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8SN8
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 6) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-04-26 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8QTH
| Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 8) | 分子名称: | 1-methyl-5-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-3-(trifluoromethyl)-7H-pyrrolo[2,3-b]pyridin-6-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ... | 著者 | Schimpl, M. | 登録日 | 2023-10-12 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | 主引用文献 | Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. J.Med.Chem., 67, 2024
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8QTG
| Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 9) | 分子名称: | 3-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-5-(trifluoromethyl)-1~{H}-pyridin-2-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ... | 著者 | Schimpl, M. | 登録日 | 2023-10-12 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.419 Å) | 主引用文献 | Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. J.Med.Chem., 67, 2024
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8TXV
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 1) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8U13
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 1) | 分子名称: | DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-30 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8TXW
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 2) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8TXX
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 3) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8U14
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 2) | 分子名称: | DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-30 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UPF
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-10-22 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQ9
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 4-residue linker | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ... | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQ8
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 2-residue linker | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ... | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQA
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, SODIUM ION, ... | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQC
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 2) | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQB
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 1) | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.484 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQD
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (condition 2. RING not modeled in density) | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.893 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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