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4RO9
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2.0A resolution structure of SRPN2 (S358E) from Anopheles gambiae
分子名称: GLYCEROL, Serpin 2
著者Lovell, S, Battaile, K.P, Zhang, X, Meekins, D.A, An, C, Michel, K.
登録日2014-10-28
公開日2014-12-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Inhibitory Effects of Hinge Loop Mutagenesis in Serpin-2 from the Malaria Vector Anopheles gambiae.
J.Biol.Chem., 290, 2015
4ROB
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2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae
分子名称: Serpin 2
著者Lovell, S, Battaile, K.P, Zhang, X, Meekins, D.A, An, C, Michel, K.
登録日2014-10-28
公開日2014-12-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae
To be Published
1MTP
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The X-ray crystal structure of a serpin from a thermophilic prokaryote
分子名称: Serine Proteinase Inhibitor (SERPIN), Chain A, Chain B
著者Irving, J.A, Cabrita, L.D, Rossjohn, J, Pike, R.N, Bottomley, S.P, Whisstock, J.C.
登録日2002-09-21
公開日2003-04-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment
Structure, 11, 2003
1T1F
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Crystal Structure of Native Antithrombin in its Monomeric Form
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, GLYCEROL, ...
著者Johnson, D.J.D, Huntington, J.A.
登録日2004-04-16
公開日2005-10-04
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation
J.Biol.Chem., 281, 2006
1QMN
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Alpha1-antichymotrypsin serpin in the delta conformation (partial loop insertion)
分子名称: ALPHA-1-ANTICHYMOTRYPSIN
著者Gooptu, B, Hazes, B, Lomas, D.A.
登録日1999-10-04
公開日2000-01-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Inactive Conformation of the Serpin Alpha1-Antichymotrypsin Indicates Two-Stage Insertion of the Reactive Loop: Implications for Inhibitory Function and Conformational Disease
Proc.Natl.Acad.Sci.USA, 97, 2000
1QMB
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Cleaved alpha-1-antitrypsin polymer
分子名称: ALPHA-1-ANTITRYPSIN
著者Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W.
登録日1999-09-24
公開日2000-02-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease
J.Mol.Biol., 293, 1999
3LW2
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Mouse Plasminogen Activator Inhibitor-1 (PAI-1)
分子名称: Plasminogen activator inhibitor 1
著者Dewilde, M, Van De Craen, B, Compernolle, G, Madsen, J.B, Strelkov, S.V, Gils, A, Declerck, P.J.
登録日2010-02-23
公開日2010-04-07
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.
J.Struct.Biol., 171, 2010
1OO8
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CRYSTAL STRUCTURE OF A1PI-PITTSBURGH IN THE NATIVE CONFORMATION
分子名称: Alpha-1-antitrypsin precursor
著者Dementiev, A, Simonovic, M, Volz, K, Gettins, P.G.
登録日2003-03-03
公開日2003-08-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
J.Biol.Chem., 278, 2003
1OYH
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Crystal Structure of P13 Alanine Variant of Antithrombin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ...
著者Johnson, D.J.D, Huntington, J.A.
登録日2003-04-04
公開日2004-04-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献The influence of hinge region residue Glu-381 on antithrombin allostery and metastability
J.Biol.Chem., 279, 2004
2BEH
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Crystal structure of antithrombin variant S137A/V317C/T401C with plasma latent antithrombin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ...
著者Johnson, D.J, Luis, S.A, Huntington, J.A.
登録日2005-10-24
公開日2005-11-01
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
J.Biol.Chem., 281, 2006
1R1L
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Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide (formyl-norleucine-LF)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin P14-P9 peptide, Antithrombin-III, ...
著者Zhou, A, Huntington, J.A, Lomas, D.A, Stein, P.E, Carrell, R.W.
登録日2003-09-24
公開日2004-10-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Serpins and the design of peptides to block intermolecular beta-linkages
To be Published
2DUT
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Crystal structure of a M-loop deletion variant of MENT in the native conformation
分子名称: Heterochromatin-associated protein MENT
著者Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A.
登録日2006-07-26
公開日2006-08-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation
Embo J., 25, 2006
3NDA
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Crystal structure of serpin from tick Ixodes ricinus
分子名称: PENTAETHYLENE GLYCOL, Serpin-2
著者Rezacova, P, Kovarova, Z, Chmelar, J, Mares, M.
登録日2010-06-07
公開日2010-10-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation.
Blood, 117, 2011
3NE4
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1.8 Angstrom structure of intact native wild-type alpha-1-antitrypsin
分子名称: Alpha-1-antitrypsin
著者Patschull, A.O.M, Gooptu, B, Segu, L.
登録日2010-06-08
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Therapeutic target-site variability in [alpha]1-antitrypsin characterized at high resolution
Acta Crystallogr.,Sect.F, 67, 2011
3NDF
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Cleaved antitrypsin with P8-P6 Asp
分子名称: Alpha-1-antitrypsin
著者Huntington, J.A, Sendall, T.J, Yamasaki, M.
登録日2010-06-07
公開日2010-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations
J. Biol. Chem., 285, 2010
3NDD
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Cleaved antitrypsin with P10 Pro, and P9-P6 Asp
分子名称: Alpha-1-antitrypsin
著者Yamasaki, M, Sendall, T.J, Huntington, J.A.
登録日2010-06-07
公開日2010-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations
J. Biol. Chem., 285, 2010
1SEK
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THE STRUCTURE OF ACTIVE SERPIN K FROM MANDUCA SEXTA AND A MODEL FOR SERPIN-PROTEASE COMPLEX FORMATION
分子名称: SERPIN K
著者Li, J, Wang, Z, Canagarajah, B, Jiang, H, Kanost, M, Goldsmith, E.J.
登録日1998-03-06
公開日1999-03-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The structure of active serpin 1K from Manduca sexta.
Structure Fold.Des., 7, 1999
1UHG
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Crystal Structure of S-Ovalbumin At 1.9 Angstrom Resolution
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ovalbumin, ...
著者Yamasaki, M, Takahashi, N, Hirose, M.
登録日2003-07-03
公開日2003-07-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of S-ovalbumin as a Non-loop-inserted Thermostabilized Serpin Form
J.Biol.Chem., 278, 2003
1PSI
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Intact recombined alpha1-antitrypsin mutant PHE 51 to LEU
分子名称: ALPHA=1=-ANTITRYPSIN
著者Abrahams, J.P, Elliott, P.R, Lomas, D.A, Carrell, R.W.
登録日1996-06-11
公開日1996-12-07
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.
Nat.Struct.Biol., 3, 1996
2B4X
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Crystal Structure of Antithrombin-III
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III
著者Adams, T.E, Huntington, J.A, Johnson, D.J.D, Bock, S.C.
登録日2005-09-27
公開日2006-10-10
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Antithrombin-III
To be Published
2ARQ
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Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh
分子名称: 14-mer from Plasminogen activator inhibitor-2, Plasminogen activator inhibitor-2
著者Di Giusto, D.A, Sutherland, A.P, Jankova, L, Harrop, S.J, Curmi, P.M, King, G.C.
登録日2005-08-21
公開日2006-07-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Plasminogen activator inhibitor-2 is highly tolerant to P8 residue substitution--implications for serpin mechanistic model and prediction of nsSNP activities
J.Mol.Biol., 353, 2005
2ANT
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THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE
分子名称: 2-acetamido-2-deoxy-beta-D-allopyranose, ANTITHROMBIN
著者Skinner, R, Abrahams, J.-P, Whisstock, J.C, Lesk, A.M, Carrell, R.W, Wardell, M.R.
登録日1997-01-28
公開日1997-06-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.
J.Mol.Biol., 266, 1997
2CEO
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thyroxine-binding globulin complex with thyroxine
分子名称: 3,5,3',5'-TETRAIODO-L-THYRONINE, GLYCEROL, THYROXINE-BINDING GLOBULIN
著者Zhou, A, Wei, Z, Read, R.J, Carrell, R.W.
登録日2006-02-08
公開日2006-08-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Mechanism for the Carriage and Release of Thyroxine in the Blood.
Proc.Natl.Acad.Sci.USA, 103, 2006
3OZQ
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Crystal structure of Serpin48, which is a highly specific serpin in the insect Tenebrio molitor
分子名称: Serpin48
著者Park, S.H, Piao, S, Ha, N.-C.
登録日2010-09-27
公開日2010-10-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional characterization of a highly specific serpin in the insect innate immunity
J.Biol.Chem., 286, 2011
1OVA
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CRYSTAL STRUCTURE OF UNCLEAVED OVALBUMIN AT 1.95 ANGSTROMS RESOLUTION
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, OVALBUMIN
著者Stein, P.E, Leslie, A.G.W.
登録日1990-11-26
公開日1992-04-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of uncleaved ovalbumin at 1.95 A resolution.
J.Mol.Biol., 221, 1991

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