PDB: 255 件ウェブページステータス検索Chemie searchBIRD

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6GWQ	Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42) 分子名称: Plasminogen Activator Inhibitor-1, VHH-2g-42 著者 Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. 登録日 2018-06-25 公開日 2020-01-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
2XN7	Crystal structure of thyroxine-binding globulin complexed with thyroxine-fluoresein (T405-CF) 分子名称: 1,2-ETHANEDIOL, 3',6'-DIHYDROXY-3-OXO-3H-SPIRO[2-BENZOFURAN-1,9'-XANTHENE]-5-CARBOXYLIC ACID, 3,5,3',5'-TETRAIODO-L-THYRONINE, ... 著者 Qi, X, Yan, Y, Wei, Z, Zhou, A. 登録日 2010-07-30 公開日 2011-02-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins. J.Biol.Chem., 286, 2011
2XN6	Crystal structure of thyroxine-binding globulin complexed with thyroxine-fluoresein 分子名称: 1,2-ETHANEDIOL, 3',6'-DIHYDROXY-3-OXO-3H-SPIRO[2-BENZOFURAN-1,9'-XANTHENE]-6-CARBOXYLIC ACID, 3,5,3',5'-TETRAIODO-L-THYRONINE, ... 著者 Qi, X, Yan, Y, Wei, Z, Zhou, A. 登録日 2010-07-30 公開日 2011-02-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins. J.Biol.Chem., 286, 2011
6GWP	Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) 分子名称: Plasminogen Activator Inhibitor-1, VHH-2g-42, VHH-2w-64 著者 Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. 登録日 2018-06-25 公開日 2020-01-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
2XN5	Crystal structure of thyroxine-binding globulin complexed with Furosemide 分子名称: 1,2-ETHANEDIOL, 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, CALCIUM ION, ... 著者 Qi, X, Yan, Y, Wei, Z, Zhou, A. 登録日 2010-07-30 公開日 2011-02-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins. J.Biol.Chem., 286, 2011
6GWN	Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) 分子名称: Plasminogen activator inhibitor 1, VHH-2g-42, VHH-2w-64 著者 Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. 登録日 2018-06-25 公開日 2020-01-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
2ZV6	Crystal structure of human squamous cell carcinoma antigen 1 分子名称: Serpin B3 著者 Zheng, B, Matoba, Y, Katagiri, C, Hibino, T, Sugiyama, M. 登録日 2008-11-01 公開日 2009-02-24 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of SCCA1 and insight about the interaction with JNK1 Biochem.Biophys.Res.Commun., 380, 2009
6FTP	Crystal form 1 of Alpha1-antichymotrypsin variant DBS-II-allo: an allosterically modulated drug-binding serpin for doxorubicin 分子名称: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, DOXORUBICIN 著者 Schmidt, K, Muller, Y.A. 登録日 2018-02-22 公開日 2018-05-23 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3LE2	Structure of Arabidopsis AtSerpin1. Native Stressed Conformation 分子名称: ACETATE ION, GLYCEROL, SULFATE ION, ... 著者 Harrop, S.J, Joss, T.V, Cumi, P.M.G, Roberts, T.H. 登録日 2010-01-14 公開日 2010-02-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21). J.Biol.Chem., 285, 2010
6ZRV	Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93) 分子名称: Plasminogen activator inhibitor 1, VHH-s-a93 (Nb93) 著者 Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. 登録日 2020-07-15 公開日 2020-08-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity. Int J Mol Sci, 21, 2020
3LW2	Mouse Plasminogen Activator Inhibitor-1 (PAI-1) 分子名称: Plasminogen activator inhibitor 1 著者 Dewilde, M, Van De Craen, B, Compernolle, G, Madsen, J.B, Strelkov, S.V, Gils, A, Declerck, P.J. 登録日 2010-02-23 公開日 2010-04-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences. J.Struct.Biol., 171, 2010
3NDD	Cleaved antitrypsin with P10 Pro, and P9-P6 Asp 分子名称: Alpha-1-antitrypsin 著者 Yamasaki, M, Sendall, T.J, Huntington, J.A. 登録日 2010-06-07 公開日 2010-07-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations J. Biol. Chem., 285, 2010
7API	THE S VARIANT OF HUMAN ALPHA1-ANTITRYPSIN, STRUCTURE AND IMPLICATIONS FOR FUNCTION AND METABOLISM 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA 1-ANTITRYPSIN, ... 著者 Loebermann, H, Tokuoka, R, Deisenhofer, J, Huber, R. 登録日 1988-09-08 公開日 1990-10-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism. Protein Eng., 2, 1989
7AQF	Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) 分子名称: 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid, Plasminogen activator inhibitor 1 著者 Sillen, M, Strelkov, S.V, Declerck, P.J. 登録日 2020-10-21 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484. Int J Mol Sci, 22, 2021
7AQG	Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) 分子名称: 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid, Plasminogen activator inhibitor 1, VHH-2g-42 (Nb42), ... 著者 Sillen, M, Strelkov, S.V, Declerck, P.J. 登録日 2020-10-21 公開日 2021-02-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484. Int J Mol Sci, 22, 2021
7AEL	alpha 1-antitrypsin (C232S) complexed with GSK716 分子名称: Alpha-1-antitrypsin, SULFATE ION, ~{N}-[(1~{S},2~{R})-1-(3-fluoranyl-2-methyl-phenyl)-1-oxidanyl-pentan-2-yl]-2-oxidanylidene-1,3-dihydroindole-4-carboxamide 著者 Chung, C. 登録日 2020-09-17 公開日 2021-03-10 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Development of a small molecule that corrects misfolding and increases secretion of Z alpha 1 -antitrypsin. Embo Mol Med, 13, 2021
7AHP	Crystal structure of Ixodes ricinus serpin - Iripin-3 分子名称: Putative salivary serpin, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM 著者 Kascakova, B, Kuta Smatanova, I, Prudnikova, T. 登録日 2020-09-25 公開日 2021-03-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro Front Immunol, 12, 2021
7B2T	Crystal structure of Iripin-5 serpin from Ixodes ricinus 分子名称: CHLORIDE ION, MAGNESIUM ION, Serpin-4 precursor, ... 著者 Kascakova, B, Kuta Smatanova, I. 登録日 2020-11-27 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus. Acta Crystallogr D Struct Biol, 77, 2021
3NDF	Cleaved antitrypsin with P8-P6 Asp 分子名称: Alpha-1-antitrypsin 著者 Huntington, J.A, Sendall, T.J, Yamasaki, M. 登録日 2010-06-07 公開日 2010-07-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations J. Biol. Chem., 285, 2010
3NDA	Crystal structure of serpin from tick Ixodes ricinus 分子名称: PENTAETHYLENE GLYCOL, Serpin-2 著者 Rezacova, P, Kovarova, Z, Chmelar, J, Mares, M. 登録日 2010-06-07 公開日 2010-10-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood, 117, 2011
3NE4	1.8 Angstrom structure of intact native wild-type alpha-1-antitrypsin 分子名称: Alpha-1-antitrypsin 著者 Patschull, A.O.M, Gooptu, B, Segu, L. 登録日 2010-06-08 公開日 2011-12-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Therapeutic target-site variability in [alpha]1-antitrypsin characterized at high resolution Acta Crystallogr.,Sect.F, 67, 2011
3OZQ	Crystal structure of Serpin48, which is a highly specific serpin in the insect Tenebrio molitor 分子名称: Serpin48 著者 Park, S.H, Piao, S, Ha, N.-C. 登録日 2010-09-27 公開日 2010-10-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and functional characterization of a highly specific serpin in the insect innate immunity J.Biol.Chem., 286, 2011
2BEH	Crystal structure of antithrombin variant S137A/V317C/T401C with plasma latent antithrombin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ... 著者 Johnson, D.J, Luis, S.A, Huntington, J.A. 登録日 2005-10-24 公開日 2005-11-01 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation. J.Biol.Chem., 281, 2006
2DUT	Crystal structure of a M-loop deletion variant of MENT in the native conformation 分子名称: Heterochromatin-associated protein MENT 著者 Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A. 登録日 2006-07-26 公開日 2006-08-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation Embo J., 25, 2006
2CEO	thyroxine-binding globulin complex with thyroxine 分子名称: 3,5,3',5'-TETRAIODO-L-THYRONINE, GLYCEROL, THYROXINE-BINDING GLOBULIN 著者 Zhou, A, Wei, Z, Read, R.J, Carrell, R.W. 登録日 2006-02-08 公開日 2006-08-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Mechanism for the Carriage and Release of Thyroxine in the Blood. Proc.Natl.Acad.Sci.USA, 103, 2006

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