PDB: 1372 件ウェブページステータス検索Chemie searchBIRD

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7A1X	KRASG12C GDP form in complex with Cpd1 分子名称: 3-(imidazol-1-ylmethyl)-1~{H}-indole, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mathieu, M, Steier, V. 登録日 2020-08-14 公開日 2021-10-13 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
7A1W	KRASG12C GDP form in complex with Cpd3 分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... 著者 Mathieu, M, Steier, V. 登録日 2020-08-14 公開日 2021-10-13 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
7A1Y	KRASG12C GDP form in complex with Cpd2 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Mathieu, M, Steier, V. 登録日 2020-08-14 公開日 2021-10-13 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.004 Å) 主引用文献 KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
7A47	KRASG12C GDP form in complex with Cpd4 分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ~{N}-[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-3-[[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-propanoyl-amino]propanamide 著者 Bertrand, T, Steier, V. 登録日 2020-08-19 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
7BTA	Crystal structure of Rheb D60K mutant bound to GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION 著者 Zhang, C, Zhang, T, Ding, J. 登録日 2020-03-31 公開日 2020-06-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling. J Mol Cell Biol, 12, 2020
7BTC	Crystal structure of Rheb Y35N mutant bound to GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE 著者 Zhang, C, Zhang, T, Ding, J. 登録日 2020-04-01 公開日 2020-06-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling. J Mol Cell Biol, 12, 2020
7BTD	Crystal structure of Rheb Y35N mutant bound to GppNHp 分子名称: GTP-binding protein Rheb, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Zhang, C, Zhang, T, Ding, J. 登録日 2020-04-01 公開日 2020-06-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling. J Mol Cell Biol, 12, 2020
4LPK	Crystal Structure of K-Ras WT, GDP-bound 分子名称: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-16 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LUC	Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C 分子名称: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-25 公開日 2013-11-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LYH	Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(4-chloro-5-iodo-2-methoxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-31 公開日 2013-11-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.371 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M1T	Crystal Structure of small molecule vinylsulfonamide 14 covalently bound to K-Ras G12C 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[(2,4-dichlorophenoxy)acetyl]piperidin-4-yl}ethanesulfonamide 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-04 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M22	Crystal Structure of small molecule acrylamide 16 covalently bound to K-Ras G12C 分子名称: 1-{4-[(2,4-dichlorophenoxy)acetyl]piperazin-1-yl}propan-1-one, GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-05 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
5P21	REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS 分子名称: C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Pai, E.F, Wittinghofer, A, Kabsch, W. 登録日 1990-04-30 公開日 1992-01-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO J., 9, 1990
4LRW	Crystal Structure of K-Ras G12C (cysteine-light), GDP-bound 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-21 公開日 2013-11-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.151 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M1S	Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[N-(2,4-dichlorophenyl)glycyl]piperidin-4-yl}ethanesulfonamide 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-04 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.552 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LV6	Crystal Structure of small molecule disulfide 4 covalently bound to K-Ras G12C 分子名称: 1-[(2,4-dichlorophenoxy)acetyl]-N-(2-sulfanylethyl)piperidine-4-carboxamide, CALCIUM ION, GTPase KRas, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-26 公開日 2013-11-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
2Y8E	Crystal structure of D. melanogaster Rab6 GTPase bound to GMPPNP 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAB-PROTEIN 6, ... 著者 Walden, M, Edwards, T.A. 登録日 2011-02-04 公開日 2011-07-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Structure of the Drosophila Melanogaster Rab6 Gtpase at 1.4 A Resolution Acta Crystallogr.,Sect.F, 67, 2011
4LYJ	Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-31 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.927 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M1O	Crystal Structure of small molecule vinylsulfonamide 7 covalently bound to K-Ras G12C 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-(1-{[(5,7-dichloro-2,2-dimethyl-1,3-benzodioxol-4-yl)oxy]acetyl}piperidin-4-yl)ethanesulfonamide 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-03 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.571 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LYF	Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(4,5-dichloro-2-hydroxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-31 公開日 2013-11-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.568 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
6JIK	Aspergillus fumigatus Rho1 GsGTP 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho GTPase Rho1 著者 Bartual, S.G, Van Aalten, D.M.F. 登録日 2019-02-22 公開日 2020-09-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Aspergillus fumigatus Rho1 gSGTP complex To Be Published
6IY1	Structure of human Ras-related protein Rab11 分子名称: GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-11A 著者 Ma, P, Li, S, Li, J. 登録日 2018-12-12 公開日 2019-12-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structure of human Ras-related protein Rab11 To Be Published
6GQX	KRAS-169 Q61H GPPNHP + CH-2 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Cruz-Migoni, A, Quevedo, C.E, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H. 登録日 2018-06-08 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5OCT	Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. 分子名称: DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, GTPase KRas, ... 著者 Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H. 登録日 2017-07-03 公開日 2018-08-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
2YC2	Intraflagellar Transport Complex 25-27 from Chlamydomonas 分子名称: CALCIUM ION, INTRAFLAGELLAR TRANSPORT PROTEIN 25, SMALL RAB-RELATED GTPASE 著者 Bhogaraju, S, Taschner, M, Lorentzen, E. 登録日 2011-03-11 公開日 2011-03-23 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.588 Å) 主引用文献 Crystal Structure of the Intraflagellar Transport Complex 25/27. Embo J., 30, 2011

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