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2H6B
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Crystal structure of oxidized CprK in complex with o-chlorophenolacetic acid
分子名称: (3-CHLORO-4-HYDROXYPHENYL)ACETIC ACID, ChloroPhenol Reduction gene K, SULFATE ION
著者Joyce, M.G, Levy, C, Leys, D.
登録日2006-05-31
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献CprK Crystal Structures Reveal Mechanism for Transcriptional Control of Halorespiration.
J.Biol.Chem., 281, 2006
2CGP
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BU of 2cgp by Molmil
CATABOLITE GENE ACTIVATOR PROTEIN/DNA COMPLEX, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*AP*TP*TP*AP*AP*TP*GP*TP*GP*AP*CP*AP*TP*AP*T)-3'), DNA (5'-D(*GP*TP*CP*AP*CP*AP*TP*TP*AP*AP*T)-3'), ...
著者Passner, J.M, Steitz, T.A.
登録日1997-01-31
公開日1998-02-04
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structure of a CAP-DNA complex having two cAMP molecules bound to each monomer.
Proc.Natl.Acad.Sci.USA, 94, 1997
4F8A
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BU of 4f8a by Molmil
Cyclic nucleotide binding-homology domain from mouse EAG1 potassium channel
分子名称: Potassium voltage-gated channel subfamily H member 1
著者Marques-Carvalho, M.J, Sahoo, N, Muskett, F.W, Vieira-Pires, R.S, Gabant, G, Cadene, M, Schonherr, R, Morais-Cabral, J.H.
登録日2012-05-17
公開日2012-07-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel.
J.Mol.Biol., 423, 2012
3UKN
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BU of 3ukn by Molmil
Structure of the C-linker/CNBHD of zELK channels in C 2 2 21 space group
分子名称: Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H (Eag-related) family
著者Brelidze, T.I.
登録日2011-11-09
公開日2012-01-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the carboxy-terminal region of a KCNH channel.
Nature, 481, 2012
4I0A
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BU of 4i0a by Molmil
structure of the mutant Catabolite gene activator protein V132A
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, GLYCEROL
著者Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J.
登録日2012-11-16
公開日2013-10-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors.
Plos Biol., 11, 2013
2GZW
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BU of 2gzw by Molmil
Crystal structure of the E.coli CRP-cAMP complex
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator
著者Kumarevel, T.S, Tanaka, T, Shinkai, A, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-05-12
公開日2007-05-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Crystal structure of activated CRP protein from E coli
To be Published
3OF1
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BU of 3of1 by Molmil
Crystal Structure of Bcy1, the Yeast Regulatory Subunit of PKA
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase regulatory subunit
著者Rinaldi, J, Wu, J, Yang, J, Ralston, C.Y, Sankaran, B, Moreno, S, Taylor, S.S.
登録日2010-08-13
公開日2010-12-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structure of Yeast Regulatory Subunit: A Glimpse into the Evolution of PKA Signaling.
Structure, 18, 2010
7ETS
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BU of 7ets by Molmil
Crystal structure of crp protein from Gardnerella Vaginalis
分子名称: Crp/Fnr family transcriptional regulator, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Dong, H.J, Wang, S, Zhang, J.M, Gu, L.
登録日2021-05-13
公開日2022-04-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Crystal structure of crp protein from Gardnerella Vaginalis
To Be Published
7T4W
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Crystal Structure of cGMP-dependent Protein Kinase
分子名称: (2R)-2-({(2S,3S)-1-[(1H-benzimidazol-2-yl)methyl]-2-phenylpiperidin-3-yl}oxy)-2-(3,5-dichlorophenyl)ethan-1-ol, CHLORIDE ION, cGMP-dependent protein kinase 1
著者Zebisch, M, Silvestre, L, Fischmann, T.O.
登録日2021-12-10
公開日2023-06-14
最終更新日2023-07-12
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
5KHG
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HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP)
分子名称: 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
著者Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
登録日2016-06-14
公開日2016-09-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.241 Å)
主引用文献Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
2XKO
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Crystal structure of the complex of NtcA with its transcriptional co- activator PipX
分子名称: 2-OXOGLUTARIC ACID, GLOBAL NITROGEN REGULATOR, PIPX
著者Llacer, J.L, Castells, M.A, Rubio, V.
登録日2010-07-11
公開日2010-08-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii.
Proc.Natl.Acad.Sci.USA, 107, 2010
6M63
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BU of 6m63 by Molmil
Crystal structure of a cAMP sensor G-Flamp1.
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Chimera of Cyclic nucleotide-gated potassium channel mll3241 and Yellow fluorescent protein
著者Zhou, Z, Chen, S, Wang, L, Chu, J.
登録日2020-03-12
公開日2021-09-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging.
Nat Commun, 13, 2022
4ONU
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cAMP-binding acyltransferase from Mycobacterium smegmatis, E234A mutant
分子名称: Acetyltransferase Pat, CALCIUM ION
著者Podobnik, M, Rebolj, K, Visweswariah, S.S.
登録日2014-01-29
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Allostery and Conformational Dynamics in cAMP-binding Acyltransferases.
J.Biol.Chem., 289, 2014
2Q0A
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BU of 2q0a by Molmil
Structure and rearrangements in the carboxy-terminal region of SpIH channels
分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
著者Flynn, G.E, Black, K.D, Islas, L.D, Sankaran, B, Zagotta, W.N.
登録日2007-05-21
公開日2007-06-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure and rearrangements in the carboxy-terminal region of SpIH channels.
Structure, 15, 2007
7T4V
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BU of 7t4v by Molmil
Crystal Structure of cGMP-dependent Protein Kinase
分子名称: 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-methylbenzoic acid, CHLORIDE ION, cGMP-dependent protein kinase 1
著者Zebisch, M, Silvestre, L, Fischmann, T.O.
登録日2021-12-10
公開日2023-06-14
最終更新日2023-07-12
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
3I59
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BU of 3i59 by Molmil
Crystal structure of MtbCRP in complex with N6-cAMP
分子名称: (2R)-N6-(1-Methyl-2-phenylethyl)adenosine-3',5'-cyclic monophosphate, (2S)-N6-(1-Methyl-2-phenylethyl)adenosine-3',5'-cyclic monophosphate, CHLORIDE ION, ...
著者Reddy, M.C, Palaninathan, S.K, Bruning, J.B, Thurman, C, Smith, D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2009-07-03
公開日2009-09-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Structural Insights into the Mechanism of the Allosteric Transitions of Mycobacterium tuberculosis cAMP Receptor Protein.
J.Biol.Chem., 284, 2009
6H7E
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BU of 6h7e by Molmil
GEF regulatory domain
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ...
著者Ferrandez, Y, Cherfils, J, Peurois, F.
登録日2018-07-31
公開日2020-02-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.
Nat Commun, 14, 2023
3PLQ
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BU of 3plq by Molmil
Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS
分子名称: (2R,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-sulfide, ZINC ION, cAMP-dependent protein kinase type I-alpha regulatory subunit
著者Swaminathan, K.
登録日2010-11-15
公開日2010-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: Conformational selection highlights a new concept in allosteric inhibitor design
To be Published
3FWE
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BU of 3fwe by Molmil
Crystal Structure of the Apo D138L CAP mutant
分子名称: Catabolite gene activator, PROLINE
著者Sharma, H, Wang, J, Kong, J, Yu, S, Steitz, T.
登録日2009-01-17
公開日2009-09-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding
Proc.Natl.Acad.Sci.USA, 106, 2009
1NE6
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BU of 1ne6 by Molmil
Crystal structure of Sp-cAMP binding R1a subunit of cAMP-dependent protein kinase
分子名称: 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, cAMP-dependent protein kinase type I-alpha regulatory chain
著者Wu, J, Jones, J.M, Xuong, N.H, Taylor, S.S.
登録日2002-12-10
公開日2004-01-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP.
Biochemistry, 43, 2004
5DZC
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Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - AMPPNP bound
分子名称: CHLORIDE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ...
著者Walker, J.R, El Bakkouri, M, Loppnau, P, Graslund, S, He, H, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, Amani, M, Structural Genomics Consortium (SGC)
登録日2015-09-25
公開日2015-10-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Proc.Natl.Acad.Sci.USA, 116, 2019
2XHK
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Crystal structure of transcription factor NtcA from Synechococcus elongatus bound to 2-oxoglutarate
分子名称: 2-OXOGLUTARIC ACID, GLOBAL NITROGEN REGULATOR
著者Llacer, J.L, Castells, M.A, Rubio, V.
登録日2010-06-17
公開日2010-08-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii.
Proc.Natl.Acad.Sci.USA, 107, 2010
3TNP
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Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit
著者Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S.
登録日2011-09-01
公開日2012-02-01
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure and allostery of the PKA RIIbeta tetrameric holoenzyme
Science, 335, 2012
3U10
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Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
著者Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A.
登録日2011-09-29
公開日2011-10-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
1Q5O
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HCN2J 443-645 in the presence of cAMP, selenomethionine derivative
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
著者Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E.
登録日2003-08-08
公開日2003-09-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献STRUCTURAL BASIS FOR MODULATION AND AGONIST SPECIFICITY OF HCN PACEMAKER CHANNELS
Nature, 425, 2003

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