PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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1NZV	Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYIpYVPA 分子名称: CHLORIDE ION, Doubly phosphorylated peptide PQpYIpYVPA, TETRAETHYLENE GLYCOL, ... 著者 Lubman, O.Y, Waksman, G. 登録日 2003-02-19 公開日 2003-04-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor J.Mol.Biol., 328, 2003
1OO3	P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase 分子名称: Phosphatidylinositol 3-kinase regulatory alpha subunit 著者 Guenther, U.L, Weyrauch, B, Schaffhausen, B. 登録日 2003-03-03 公開日 2003-03-25 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity Biochemistry, 42, 2003
1OO4	P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase complexed to a peptide derived from PDGFr 分子名称: 8-mer peptide from PDGFr, Phosphatidylinositol 3-kinase regulatory alpha subunit 著者 Guenther, U.L, Weyrauch, B, Schaffhausen, B. 登録日 2003-03-03 公開日 2003-03-25 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity Biochemistry, 42, 2003
1OPK	Structural basis for the auto-inhibition of c-Abl tyrosine kinase 分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... 著者 Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. 登録日 2003-03-06 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
1OPL	Structural basis for the auto-inhibition of c-Abl tyrosine kinase 分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase 著者 Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. 登録日 2003-03-06 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
1P13	Crystal Structure of the Src SH2 Domain Complexed with Peptide (SDpYANFK) 分子名称: CACODYLATE ION, Peptide, Proto-oncogene tyrosine-protein kinase Src 著者 Sonnenburg, E.D, Bilwes, A, Hunter, T, Noel, J.P. 登録日 2003-04-11 公開日 2003-08-19 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry, 42, 2003
1O4P	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78791. 分子名称: 2-PHENYLMALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4J	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24. 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O43	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82129. 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [4-((1Z)-2-(ACETYLAMINO)-3-{[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]AMINO}-3-OXOPROP-1-ENYL)-2-FORMYLPHENYL]ACET IC ACID 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O49	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85493. 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, {4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENOXY}-ACETIC ACID 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4G	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH DPI59. 分子名称: HYDROXY(1-NAPHTHYL)METHYLPHOSPHONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4M	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH MALONICACID. 分子名称: MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O45	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU84687. 分子名称: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3-FORMYL-O-PHOSPHONOTYROSINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4F	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79073. 分子名称: 1,2,3,4-TETRAHYDROQUINOLIN-8-YL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4K	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PASBN. 分子名称: BENZYL 2-FORMYLPHENYL HYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O46	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395. 分子名称: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-METHOXYCARBONYL-PHENYL}-2-FLUORO-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O41	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78300. 分子名称: 2-FORMYL-6-METHOXYPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O47	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209. 分子名称: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-4-[DIFLUORO(PHOSPHONO)METHYL]PHENYLALANINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4H	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79072. 分子名称: 2-CYANOQUINOLIN-8-YL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4L	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2. 分子名称: CITRIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4A	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82197. 分子名称: 4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-FORMYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4B	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU83876. 分子名称: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3,4-DIPHOSPHONOPHENYLALANINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O42	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU81843. 分子名称: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-O-PHOSPHONOTYROSINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4E	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78299. 分子名称: 2,6-DIFORMYL-4-METHYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4R	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78783. 分子名称: (PHENYL-PHOSPHONO-METHYL)-PHOSPHONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003

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