PDB: 144 件ウェブページステータス検索Chemie searchBIRD

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8Q1G	LSD1-CoREST bound to Acetylated K14 of Histone H3 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.3C, Lysine-specific histone demethylase 1A, ... 著者 Barone, M, Mattevi, A. 登録日 2023-07-31 公開日 2024-05-15 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1. Nat.Chem.Biol., 2024
8Q1J	LSD1 Y391K-CoREST bound to Acetylated K14 of Histone H3 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.3C, Lysine-specific histone demethylase 1A, ... 著者 Barone, M, Mattevi, A. 登録日 2023-07-31 公開日 2024-05-15 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.87 Å) 主引用文献 Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1. Nat.Chem.Biol., 2024
8RBX	Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. 登録日 2023-12-05 公開日 2024-02-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 629, 2024
7W6L	The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide 分子名称: Histone H3.3C, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ... 著者 Zhao, L, Li, Y, Chen, Y. 登録日 2021-12-01 公開日 2022-09-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
7W6I	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me1 peptide 分子名称: Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... 著者 Zhao, L, Li, Y, Chen, Y. 登録日 2021-12-01 公開日 2022-09-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
7W6J	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide 分子名称: Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... 著者 Zhao, L, Li, Y, Chen, Y. 登録日 2021-12-01 公開日 2022-09-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
7W67	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide 分子名称: Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... 著者 Zhao, L, Li, Y, Chen, Y. 登録日 2021-12-01 公開日 2022-09-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.194 Å) 主引用文献 Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
3AV1	The human nucleosome structure containing the histone variant H3.2 分子名称: 146-MER DNA, Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Tachiwana, H, Osakabe, A, Shiga, T, Miya, Y, Kimura, H, Kagawa, W, Kurumizaka, H. 登録日 2011-02-18 公開日 2011-06-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of human nucleosomes containing major histone H3 variants Acta Crystallogr.,Sect.D, 67, 2011
5AY8	Crystal structure of human nucleosome containing H3.Y 分子名称: CHLORIDE ION, DNA (146-MER), H3.Y, ... 著者 Kujirai, T, Horikoshi, N, Sato, K, Maehara, K, Machida, S, Osakabe, A, Kimura, H, Ohkawa, Y, Kurumizaka, H. 登録日 2015-08-10 公開日 2016-04-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure and function of human histone H3.Y nucleosome Nucleic Acids Res., 44, 2016
5GXQ	The crystal structure of the nucleosome containing H3.6 分子名称: DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Taguchi, H, Xie, Y, Horikoshi, N, Kurumizaka, H. 登録日 2016-09-19 公開日 2017-04-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 Biochemistry, 56, 2017
8KB5	Cryo-EM structure of the human nucleosome containing H3.8 分子名称: DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Hirai, H, Kujirai, T, Takizawa, Y, Kurumizaka, H. 登録日 2023-08-03 公開日 2023-10-18 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.26133 Å) 主引用文献 Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.8. J.Biochem., 174, 2023
4O30	Crystal structure of ATXR5 in complex with histone H3.1 and AdoHcy 分子名称: BETA-MERCAPTOETHANOL, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase ATXR6, ... 著者 Bergamin, E, Mongeon, V, Couture, J.F. 登録日 2013-12-17 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication. Science, 343, 2014
7EA5	Yeast Set2 bound to a nucleosome containing oncohistone mutations 分子名称: 601-DNA, Histone H2A, Histone H2B, ... 著者 Jing, H, Liu, Y. 登録日 2021-03-06 公開日 2021-07-14 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations. Cell Discov, 7, 2021
2CU9	Crystal structure of Histone chaperone cia1 分子名称: 2-(2-METHOXYETHOXY)ETHANOL, Histone chaperone cia1 著者 Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-25 公開日 2006-08-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structures of Fission Yeast Histone Chaperone Asf1 Complexed with the Hip1 B-domain or the Cac2 C Terminus J.Biol.Chem., 283, 2008
5TPX	Bromodomain from Plasmodium Faciparum Gcn5, complexed with compound 分子名称: (1S,2S)-N~1~,N~1~-dimethyl-N~2~-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine, CHLORIDE ION, Histone acetyltransferase GCN5, ... 著者 Lin, Y.H, Hou, C.F.D, MOUSTAKIM, M, DIXON, D.J, Loppnau, P, Tempel, W, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, BRENNAN, P.E, Walker, J.R, Structural Genomics Consortium (SGC) 登録日 2016-10-21 公開日 2017-01-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of a PCAF Bromodomain Chemical Probe. Angew. Chem. Int. Ed. Engl., 56, 2017
5MG2	Crystal structure of the second bromodomain of human TAF1 in complex with BAY-299 chemical probe 分子名称: 1,2-ETHANEDIOL, 6-(3-oxidanylpropyl)-2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, Transcription initiation factor TFIID subunit 1 著者 Tallant, C, Bouche, L, Holton, S.J, Fedorov, O, Siejka, P, Picaud, S, Krojer, T, Srikannathasan, V, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hartung, I.V, Haendler, B, Muller, S, Huber, K.V.M, Structural Genomics Consortium (SGC) 登録日 2016-11-20 公開日 2017-05-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J. Med. Chem., 60, 2017
5N49	BRPF2 in complex with Compound 7 分子名称: 2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, Bromodomain-containing protein 1 著者 Bouche, L, Christ, C.D, Siegel, S, Fernandez-Montalvan, A.E, Holton, S.J, Fedorov, O, ter Laak, A, Sugawara, T, Stoeckigt, D, Tallant, C, Bennett, J, Monteiro, O, Saez, L.D, Siejka, P, Meier, J, Puetter, V, Weiske, J, Mueller, S, Huber, K.V.M, Hartung, I.V, Haendler, B. 登録日 2017-02-10 公開日 2017-05-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J. Med. Chem., 60, 2017
2LBM	Solution structure of the ADD domain of ATRX complexed with histone tail H3 1-15 K9me3 分子名称: Transcriptional regulator ATRX, ZINC ION, histone tail H3 K9me3 著者 Eustermann, S, Yang, J, Neuhaus, D. 登録日 2011-04-08 公開日 2011-06-29 最終更新日 2011-07-13 実験手法 SOLUTION NMR 主引用文献 Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin Nat.Struct.Mol.Biol., 2011
2RI5	Crystal structure of the 3-MBT repeats from human L3MBTL1 with N358A point mutation 分子名称: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, TRIETHYLENE GLYCOL 著者 Li, H, Patel, D.J. 登録日 2007-10-10 公開日 2007-12-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RI2	Crystal structure of the 3-MBT repeats from human L3MBTL1 with D355A point mutation 分子名称: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, SULFATE ION, ... 著者 Li, H, Patel, D.J. 登録日 2007-10-10 公開日 2007-12-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
7T7T	Structure of TSK/BRU1 bound to histone H3.1 分子名称: Histone H3.1, Protein TONSOKU 著者 Davarinejad, H, Couture, J.F. 登録日 2021-12-15 公開日 2022-03-30 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication. Science, 375, 2022
2RHI	Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with H1.5K27me2 at 1.66 angstrom 分子名称: DI(HYDROXYETHYL)ETHER, Histone H1.5, Lethal(3)malignant brain tumor-like protein, ... 著者 Li, H, Patel, D.J. 登録日 2007-10-09 公開日 2007-12-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RHY	Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to monomethyl-lysine 分子名称: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, N-METHYL-LYSINE 著者 Li, H, Patel, D.J. 登録日 2007-10-09 公開日 2007-12-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RHX	Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to dimethyl-lysine 分子名称: Lethal(3)malignant brain tumor-like protein, N-DIMETHYL-LYSINE, SULFATE ION, ... 著者 Li, H, Patel, D.J. 登録日 2007-10-09 公開日 2007-12-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RI3	Crystal structure of the 3-MBT repeats from human L3MBTL1 with N358Q point mutation 分子名称: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein 著者 Li, H, Patel, D.J. 登録日 2007-10-10 公開日 2007-12-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007

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