PDB: 896 件ウェブページステータス検索Chemie searchBIRD

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3HLG	Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with lovastatin 分子名称: (3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID, Transesterase 著者 Sawaya, M.R, Yeates, T.O, Pashkov, I, Gao, X, Tang, Y. 登録日 2009-05-27 公開日 2009-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
3HLE	Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with monacolin J acid 分子名称: (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Transesterase 著者 Sawaya, M.R, Yeates, T.O, Pashkov, I, Gao, X, Tang, Y. 登録日 2009-05-27 公開日 2009-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
3HLF	Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with simvastatin 分子名称: Simvastatin acid, Transesterase 著者 Sawaya, M.R, Yeates, T.O, Pashkov, I, Gao, X, Tang, Y. 登録日 2009-05-27 公開日 2009-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
1R4Z	Bacillus subtilis lipase A with covalently bound Rc-IPG-phosphonate-inhibitor 分子名称: Lipase, [(4R)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL]METHYL HYDROGEN HEX-5-ENYLPHOSPHONATE 著者 Droege, M.J, Van Pouderoyen, G, Vrenken, T.E, Rueggeberg, C.J, Reetz, M.T, Dijkstra, B.W, Quax, W.J. 登録日 2003-10-09 公開日 2004-10-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Directed Evolution of Bacillus subtilis Lipase A by Use of Enantiomeric Phosphonate Inhibitors: Crystal Structures and Phage Display Selection Chembiochem, 7, 2005
1R50	Bacillus subtilis lipase A with covalently bound Sc-IPG-phosphonate-inhibitor 分子名称: Lipase, [(4S)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL]METHYL HYDROGEN HEX-5-ENYLPHOSPHONATE 著者 Droege, M.J, Van Pouderoyen, G, Vrenken, T.E, Rueggeberg, C.J, Reetz, M.T, Dijkstra, B.W, Quax, W.J. 登録日 2003-10-09 公開日 2004-10-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Directed Evolution of Bacillus subtilis Lipase A by Use of Enantiomeric Phosphonate Inhibitors: Crystal Structures and Phage Display Selection Chembiochem, 7, 2005
7VUS	Crystal structure of AlleyCat9 with 5-nitro-benzotriazole 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-nitro-1H-benzotriazole, AlleyCat, ... 著者 Tame, J.R.H, Korendovych, I.V, Margheritis, E, Takahashi, K. 登録日 2021-11-04 公開日 2022-07-27 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 NMR-guided directed evolution. Nature, 610, 2022
7VUR	Crystal structure of AlleyCat9 with calcium but no inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, AlleyCat, CALCIUM ION 著者 Margheritis, E, Takahashi, K, Korendovych, I.V, Tame, J.R.H. 登録日 2021-11-04 公開日 2022-07-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 NMR-guided directed evolution. Nature, 610, 2022
7VUC	Myoglobin mutant L29I/H64G/V68A 分子名称: IMIDAZOLE, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE 著者 Takahashi, K, Korendovych, I.V, Tame, J.R.H. 登録日 2021-11-02 公開日 2022-07-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 NMR-guided directed evolution. Nature, 610, 2022
7VUU	Crystal structure of AlleyCat10 with inhibitor 分子名称: 5-nitro-1H-benzotriazole, AlleyCat, CALCIUM ION 著者 Tame, J.R.H, Korendovych, I.V, Margheritis, E, Takahashi, K. 登録日 2021-11-04 公開日 2022-07-27 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 NMR-guided directed evolution. Nature, 610, 2022
7VUT	Crystal structure of AlleyCat10 分子名称: AlleyCat10, CALCIUM ION 著者 Tame, J.R.H, Korendovych, I.V, Margheritis, E, Takahashi, K. 登録日 2021-11-04 公開日 2022-07-27 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 NMR-guided directed evolution. Nature, 610, 2022
3PKQ	Q83D Variant of S. Enterica RmlA with dGTP 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, Glucose-1-phosphate thymidylyltransferase, ... 著者 Chang, A, Moretti, R, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) 登録日 2010-11-11 公開日 2011-01-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution. J.Biol.Chem., 286, 2011
3PKP	Q83S Variant of S. Enterica RmlA with dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Glucose-1-phosphate thymidylyltransferase, MAGNESIUM ION 著者 Chang, A, Moretti, R, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) 登録日 2010-11-11 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution. J.Biol.Chem., 286, 2011
1HTZ	CRYSTAL STRUCTURE OF TEM52 BETA-LACTAMASE 分子名称: BETA-LACTAMASE MUTANT TEM52 著者 Stevens, R.C, Orencia, M.C. 登録日 2001-01-03 公開日 2001-03-21 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Predicting the emergence of antibiotic resistance by directed evolution and structural analysis. Nat.Struct.Biol., 8, 2001
4XBX	Crystal Structure of the L74F/M78F/L103V/L114V/I116V/F139V/L147V mutant of LEH 分子名称: Limonene-1,2-epoxide hydrolase 著者 Kong, X.D, Sun, Z, Xu, J.H, Reetz, M.T, Zhou, J. 登録日 2014-12-17 公開日 2015-07-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54, 2015
4XBT	Crystal Structure of the L74F/M78F/L103V/L114V/I116V/F139V/L147V mutant of LEH complexed with (S,S)-cyclohexanediol 分子名称: (1S,2S)-cyclohexane-1,2-diol, CITRATE ANION, Limonene-1,2-epoxide hydrolase 著者 Kong, X.D, Sun, Z, Lonsdale, R, Xu, J.H, Reetz, M.T, Zhou, J. 登録日 2014-12-17 公開日 2015-07-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54, 2015
4XDV	Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclohexanediol 分子名称: (1R,2R)-cyclohexane-1,2-diol, Limonene-1,2-epoxide hydrolase 著者 Kong, X.D, Sun, Z, Lonsdale, R, Xu, J.H, Reetz, M.T, Zhou, J. 登録日 2014-12-20 公開日 2015-07-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54, 2015
4XBY	Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclopentene oxide 分子名称: (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase 著者 Kong, X.D, Sun, Z, Xu, J.H, Reetz, M.T, Zhou, J. 登録日 2014-12-17 公開日 2015-07-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54, 2015
4XDW	Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH 分子名称: Limonene-1,2-epoxide hydrolase 著者 Kong, X.D, Sun, Z, Lonsdale, R, Xu, J.H, Reetz, M.T, Zhou, J. 登録日 2014-12-20 公開日 2015-07-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54, 2015
2DCY	Crystal structure of Bacillus subtilis family-11 xylanase 分子名称: 1,4-DIETHYLENE DIOXIDE, D(-)-TARTARIC ACID, Endo-1,4-beta-xylanase A, ... 著者 Kondo, H, Miyazaki, K, Takenouchi, M, Noro, N, Suzuki, M, Tsuda, S. 登録日 2006-01-18 公開日 2006-02-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Thermal Stabilization of Bacillus subtilis Family-11 Xylanase by Directed Evolution J.Biol.Chem., 281, 2006
3ZEV	Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion 分子名称: GLYCINE, NEUROTENSIN, NEUROTENSIN RECEPTOR 1 TM86V 著者 Egloff, P, Hillenbrand, M, Schlinkmann, K.M, Batyuk, A, Mittl, P, Plueckthun, A. 登録日 2012-12-07 公開日 2014-01-29 最終更新日 2014-02-26 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli Proc.Natl.Acad.Sci.USA, 111, 2014
4PC8	Structure-based protein engineering efforts on the scaffold of a monomeric triosephosphate isomerase yielding a sugar isomerase 分子名称: GLYCOLIC ACID, Ma21-TIM 著者 Krause, M, Neubauer, P, Wierenga, R.K. 登録日 2014-04-14 公開日 2015-04-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activity. Acta Crystallogr.,Sect.F, 72, 2016
4PCF	Structure-based protein engineering of a monomeric triosephosphate isomerase towards changing substrate specificity 分子名称: Ma18-TIM 著者 Krause, M, Neubauer, P, Wierenga, R.K. 登録日 2014-04-15 公開日 2015-04-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activity. Acta Crystallogr.,Sect.F, 72, 2016
5OOU	Designed Ankyrin Repeat Protein (DARPin) YTRL-1 selected by directed evolution against Lysozyme 分子名称: DARPin YTRL-1 著者 Fischer, G, Hogan, B.J, Houlihan, G, Edmond, S, Huovinen, T.T.K, Hollfelder, F, Hyvonen, M. 登録日 2017-08-08 公開日 2018-08-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.104 Å) 主引用文献 Designed Ankyrin Repeat Protein (DARPin) YTRL-1 selected by directed evolution against Lysozyme To be published
5OP3	Designed Ankyrin Repeat Protein (DARPin) NDNH-1 selected by directed evolution against Lysozyme 分子名称: ACETATE ION, CALCIUM ION, CHLORIDE ION, ... 著者 Fischer, G, Hogan, B.J, Houlihan, G, Edmond, S, Huovinen, T.T.K, Hollfelder, F, Hyvonen, M. 登録日 2017-08-09 公開日 2018-08-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.359 Å) 主引用文献 Designed Ankyrin Repeat Protein (DARPin) NDNH-1 selected by directed evolution against Lysozyme To be published
5OOS	Designed Ankyrin Repeat Protein (DARPin) YTRL-2 selected by directed evolution against Lysozyme 分子名称: CHLORIDE ION, DARPin YTRL-2, NONAETHYLENE GLYCOL 著者 Hogan, B.J, Fischer, G, Houlihan, G, Edmond, S, Huovinen, T.T.K, Hollfelder, F, Hyvonen, M. 登録日 2017-08-08 公開日 2018-08-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Designed Ankyrin Repeat Protein (DARPin) YTRL-2 selected by directed evolution against Lysozyme To be published

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