5I38
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![BU of 5i38 by Molmil](/molmil-images/mine/5i38) | Crystal Structure of tyrosinase from Bacillus megaterium with inhibitor kojic acid in the active site | 分子名称: | 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE, COPPER (II) ION, Tyrosinase | 著者 | Kanteev, M, Goldfeder, M, Deri, B, Adir, N, Fishman, A. | 登録日 | 2016-02-10 | 公開日 | 2016-10-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The unravelling of the complex pattern of tyrosinase inhibition. Sci Rep, 6, 2016
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8ESF
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5I3D
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![BU of 5i3d by Molmil](/molmil-images/mine/5i3d) | Sulfolobus solfataricus beta-glycosidase - E387Y mutant | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ACETATE ION, Beta-galactosidase | 著者 | Iglesias-Fernandez, J, Hancock, S.M, Lee, S.S, McAuley, K.E, Fordham-Skelton, A, Rovira, C, Davis, B.D. | 登録日 | 2016-02-10 | 公開日 | 2017-02-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | A front-face 'SNi synthase' engineered from a retaining 'double-SN2' hydrolase. Nat. Chem. Biol., 13, 2017
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1B9X
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8CGA
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![BU of 8cga by Molmil](/molmil-images/mine/8cga) | Structure of Mycobacterium tuberculosis dUTPase delta 133A-137S mutant | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | 著者 | Toth, Z.S, Benedek, A, Leveles, I, Vertessy, B.G. | 登録日 | 2023-02-03 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structure of Mycobacterium tuberculosis dUTPase delta 133A-137S mutant To Be Published
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8C0Y
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5I95
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![BU of 5i95 by Molmil](/molmil-images/mine/5i95) | Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid | 分子名称: | 2-OXOGLUTARIC ACID, ACETATE ION, CALCIUM ION, ... | 著者 | Zhang, B, Jin, L, Wu, W, Jiang, F, DeLaBarre, B, Travins, J.A, Padyana, A.K. | 登録日 | 2016-02-19 | 公開日 | 2017-03-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discov, 7, 2017
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6UJ4
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6OVC
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![BU of 6ovc by Molmil](/molmil-images/mine/6ovc) | hMcl1 inhibitor complex | 分子名称: | (2S)-N-(benzylsulfonyl)-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Poppe, L. | 登録日 | 2019-05-07 | 公開日 | 2019-05-22 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies. Cancer Discov, 8, 2018
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6YBL
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![BU of 6ybl by Molmil](/molmil-images/mine/6ybl) | Structure of MBP-Mcl-1 in complex with compound 9m | 分子名称: | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Dokurno, P, Surgenor, A.E, Murray, J.B. | 登録日 | 2020-03-17 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor. J.Med.Chem., 63, 2020
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8CGZ
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![BU of 8cgz by Molmil](/molmil-images/mine/8cgz) | tubulin-AB8939 complex | 分子名称: | 1-[4-[2-[[5-(ethoxymethyl)-2-methyl-phenyl]amino]-1,3-oxazol-5-yl]phenyl]imidazolidin-2-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Varela, P.F, Gigant, B. | 登録日 | 2023-02-06 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.527 Å) | 主引用文献 | Development of AB8939, a Novel Colchicine-like Microtubule Synthetic Destabilizer with the Ability to Overcome Multidrug Resistance TO BE PUBLISHED
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8F7I
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![BU of 8f7i by Molmil](/molmil-images/mine/8f7i) | The condensation domain of surfactin A synthetase C variant 18b in space group P43212 | 分子名称: | GLYCEROL, Surfactin synthetase | 著者 | Frota, N.F, Pistofidis, A, Folger, I.B, Hilvert, D, Schmeing, M. | 登録日 | 2022-11-18 | 公開日 | 2023-11-22 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 20, 2024
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8F47
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6S9N
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![BU of 6s9n by Molmil](/molmil-images/mine/6s9n) | Designed Armadillo Repeat protein Lock2 fused to target peptide KRKRKAKLSF | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Lock2_KRKRKAKLSF | 著者 | Ernst, P, Zosel, F, Reichen, C, Schuler, B, Pluckthun, A. | 登録日 | 2019-07-15 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. Acs Chem.Biol., 15, 2020
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5KSD
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![BU of 5ksd by Molmil](/molmil-images/mine/5ksd) | Crystal Structure of a Plasma Membrane Proton Pump | 分子名称: | ATPase 2, plasma membrane-type, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Croll, T, Pedersen, B.P, Nissen, P. | 登録日 | 2016-07-08 | 公開日 | 2016-08-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Improved Model of Proton Pump Crystal Structure Obtained by Interactive Molecular Dynamics Flexible Fitting Expands the Mechanistic Model for Proton Translocation in P-Type ATPases. Front Physiol, 8, 2017
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1N8R
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![BU of 1n8r by Molmil](/molmil-images/mine/1n8r) | Structure of large ribosomal subunit in complex with virginiamycin M | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L10e, 50S ribosomal protein L13P, ... | 著者 | Hansen, J.L, Moore, P.B, Steitz, T.A. | 登録日 | 2002-11-21 | 公開日 | 2003-07-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of
the Large Ribosomal Subunit J.Mol.Biol., 330, 2003
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6UUY
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7Q1R
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![BU of 7q1r by Molmil](/molmil-images/mine/7q1r) | A de novo designed homo-dimeric antiparallel coiled coil apCC-Di | 分子名称: | ETHANOL, SODIUM ION, apCC-Di | 著者 | Shanmugaratnam, S, Rhys, G.G, Dawson, W.M, Woolfson, D.N, Hocker, B. | 登録日 | 2021-10-20 | 公開日 | 2022-07-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | De novo designed peptides for cellular delivery and subcellular localisation. Nat.Chem.Biol., 18, 2022
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8CYE
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8FJ5
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![BU of 8fj5 by Molmil](/molmil-images/mine/8fj5) | Structure of the Haloferax volcanii archaeal type IV pilus | 分子名称: | Pilin_N domain-containing protein | 著者 | Wang, F, Kreutzberger, M.A, Baquero, D.P, Krupovic, M, Egelman, E.H. | 登録日 | 2022-12-19 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The evolution of archaeal flagellar filaments. Proc.Natl.Acad.Sci.USA, 120, 2023
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6EA5
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![BU of 6ea5 by Molmil](/molmil-images/mine/6ea5) | Structure of BDBV GPcl in complex with the pan-ebolavirus mAb ADI-15878 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-15878 Fab Heavy Chain, ... | 著者 | King, L.B, West, B.R, Moyer, C.L, Fusco, M.L, Milligan, J.C, Hui, S, Saphire, E.O. | 登録日 | 2018-08-02 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (4.75 Å) | 主引用文献 | Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope. MBio, 9, 2018
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4X4Z
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6YBJ
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![BU of 6ybj by Molmil](/molmil-images/mine/6ybj) | Structure of MBP-Mcl-1 in complex with compound 3e | 分子名称: | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[(2-methylpyrazol-3-yl)methoxy]phenyl]propanoic acid, CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, ... | 著者 | Dokurno, P, Surgenor, A.E, Murray, J.B. | 登録日 | 2020-03-17 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor. J.Med.Chem., 63, 2020
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4WZ3
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![BU of 4wz3 by Molmil](/molmil-images/mine/4wz3) | Crystal structure of the complex between LubX/LegU2/Lpp2887 U-box 1 and Homo sapiens UBE2D2 | 分子名称: | E3 ubiquitin-protein ligase LubX, Ubiquitin-conjugating enzyme E2 D2 | 著者 | Stogios, P.J, Quaile, A.T, Skarina, T, Nocek, B, Di Leo, R, Yim, V, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-11-18 | 公開日 | 2015-01-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila. Structure, 23, 2015
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6OY3
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