PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

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5AL2	Crystal structure of TNKS2 in complex with 2-(4-(propan-2-yl)phenyl)- 1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one 分子名称: (2S)-2-(4-propan-2-ylphenyl)-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Lehtio, L. 登録日 2015-03-06 公開日 2015-07-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of Potent and Selective Nonplanar Tankyrase Inhibiting Nicotinamide Mimics. Bioorg.Med.Chem., 23, 2015
5WC2	Crystal Structure of ADP-bound human TRIP13 分子名称: ADENOSINE-5'-DIPHOSPHATE, Pachytene checkpoint protein 2 homolog 著者 Jeong, B.-C, Luo, X. 登録日 2017-06-29 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing. Nat Commun, 8, 2017
2UYI	Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 33 分子名称: (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... 著者 Lee, T.T. 登録日 2007-04-07 公開日 2007-05-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
5A4X	The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions and Zn 分子名称: AT3G17980, CALCIUM ION, ZINC ION 著者 Diaz, M, Albert, A. 登録日 2015-06-15 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Calcium-Dependent Oligomerization of Car Proteins at Cell Membrane Modulates Aba Signaling. Proc.Natl.Acad.Sci.USA, 113, 2016
7V1M	Structural basis for the co-chaperone relationship of sNASP and ASF1b 分子名称: Histone H3.3, Histone H4, Histone chaperone ASF1B, ... 著者 Bao, H, Huang, H. 登録日 2021-08-04 公開日 2022-04-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.834 Å) 主引用文献 NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes. Nucleic Acids Res., 50, 2022
5A5B	Structure of the 26S proteasome-Ubp6 complex 分子名称: 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG, 26S PROTEASE REGULATORY SUBUNIT 6A, 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG, ... 著者 Aufderheide, A, Beck, F, Stengel, F, Hartwig, M, Schweitzer, A, Pfeifer, G, Goldberg, A.L, Sakata, E, Baumeister, W, Foerster, F. 登録日 2015-06-17 公開日 2015-07-22 最終更新日 2017-08-30 実験手法 ELECTRON MICROSCOPY (9.5 Å) 主引用文献 Structural Characterization of the Interaction of Ubp6 with the 26S Proteasome. Proc.Natl.Acad.Sci.USA, 112, 2015
5A50	The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions, Zn and Phopho Choline 分子名称: AT3G17980, CALCIUM ION, PHOSPHOCHOLINE, ... 著者 Diaz, M, Albert, A. 登録日 2015-06-16 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Calcium-Dependent Oligomerization of Car Proteins at Cell Membrane Modulates Aba Signaling. Proc.Natl.Acad.Sci.USA, 113, 2016
7UFV	Crystal structure of the WDR domain of human DCAF1 in complex with OICR-6766 分子名称: (3P)-N-[(1S)-3-amino-1-(3-chlorophenyl)-3-oxopropyl]-3-(2-fluorophenyl)-1H-pyrazole-4-carboxamide, DDB1- and CUL4-associated factor 1, UNKNOWN ATOM OR ION 著者 Kimani, S, Li, A, Li, Y, Dong, A, Hutchinson, A, Seitova, A, Wilson, B, Al-Awar, R, Vedadi, M, Brown, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2022-03-23 公開日 2022-05-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of Nanomolar DCAF1 Small Molecule Ligands. J.Med.Chem., 66, 2023
2UZI	Crystal structure of HRAS(G12V) - anti-RAS Fv complex 分子名称: ANTI-RAS FV HEAVY CHAIN, ANTI-RAS FV LIGHT CHAIN, GTPASE HRAS, ... 著者 Tanaka, T, williams, R.L, Rabbitts, T.H. 登録日 2007-04-27 公開日 2007-06-26 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Tumour Prevention by a Single Antibody Domain Targeting the Interaction of Signal Transduction Proteins with Ras. Embo J., 26, 2007
5IAW	Novel natural FXR modulator with a unique binding mode 分子名称: (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-hydroxybenzoate, Bile acid receptor, Peptide from Nuclear receptor coactivator 2 著者 Lu, Y, Li, Y. 登録日 2016-02-22 公開日 2017-03-08 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly Chembiochem, 18, 2017
5W5Q	MAP4K4 in complex with inhibitor compound 12 (N3-methyl-10-(3-methyl-3-(5-methyloxazol-2-yl)but-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2,3-dicarboxamide) 分子名称: (5s,7s)-N~3~-methyl-10-[3-methyl-3-(5-methyl-1,3-oxazol-2-yl)but-1-yn-1-yl]-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide, Mitogen-activated protein kinase kinase kinase kinase 4 著者 Harris, S.F, Wu, P. 登録日 2017-06-15 公開日 2018-06-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1). Acs Med.Chem.Lett., 10, 2019
2UYM	Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 37 分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ... 著者 Lee, T.T. 登録日 2007-04-10 公開日 2007-05-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
5AL5	Crystal structure of TNKS2 in complex with 2-(4-((pyridin-4-yl)methyl) piperazin-1-yl)-3,4,5,6,7,8-hexahydroquinazolin-4-one 分子名称: 2-(4-((pyridin-4-yl)methyl)piperazin-1-yl)-3,4,5,6,7,8-hexahydroquinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Lehtio, L. 登録日 2015-03-06 公開日 2015-07-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of Potent and Selective Nonplanar Tankyrase Inhibiting Nicotinamide Mimics. Bioorg.Med.Chem., 23, 2015
2V6Q	Crystal Structure of a BHRF-1 : Bim BH3 complex 分子名称: BCL-2-LIKE PROTEIN 11, BHRF1 PROTEIN, BROMIDE ION 著者 Kvansakul, M, Huang, D.C.S, Colman, P.M. 登録日 2007-07-20 公開日 2008-08-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1. Plos Pathog., 6, 2010
4QSK	Crystal Structure of L. monocytogenes Pyruvate Carboxylase in complex with Cyclic-di-AMP 分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CITRATE ANION, MANGANESE (II) ION, ... 著者 Choi, P.H, Tong, L. 登録日 2014-07-04 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function. Cell(Cambridge,Mass.), 158, 2014
2UZG	Zf-UBP domain of VDU1 分子名称: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 33, ZINC ION 著者 Allen, M.D, Bycroft, M. 登録日 2007-04-27 公開日 2007-05-08 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The Solution Structure of the Znf Ubp Domain of Usp33/Vdu1. Protein Sci., 16, 2007
5YIV	Caulobacter crescentus GcrA DNA-binding domain(DBD) in complex with methylated dsDNA(crystal form 1) 分子名称: Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*GP*(6MA)P*AP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*(6MA)P*TP*TP*CP*G)-3') 著者 Wu, X, Zhang, Y. 登録日 2017-10-06 公開日 2018-03-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.914 Å) 主引用文献 Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
5AL3	Crystal structure of TNKS2 in complex with 2-(2,4-dichlorophenyl)-1- methyl-1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one 分子名称: (2R)-2-(2,4-dichlorophenyl)-1-methyl-2,3-dihydropyrido[2,3-d]pyrimidin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Lehtio, L. 登録日 2015-03-06 公開日 2015-07-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of Potent and Selective Nonplanar Tankyrase Inhibiting Nicotinamide Mimics. Bioorg.Med.Chem., 23, 2015
4L8M	Human p38 MAP kinase in complex with a Dibenzoxepinone 分子名称: Mitogen-activated protein kinase 14, N-[2-fluoro-5-({9-[2-(morpholin-4-yl)ethoxy]-11-oxo-6,11-dihydrodibenzo[b,e]oxepin-3-yl}amino)phenyl]benzamide, octyl beta-D-glucopyranoside 著者 Richters, A, Mayer-Wrangowski, S.C, Gruetter, C, Rauh, D. 登録日 2013-06-17 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood. J.Med.Chem., 56, 2013
5YGF	Crystal structure of Drosophila melanogaster Papi extended Tudor domain (D287A) in complex with Piwi N-terminal R10-unme peptide 分子名称: ASP-GLN-GLY-ARG-GLY-ARG-ARG-ARG-PRO, GH18329p 著者 Zhang, Y.H, Huang, Y. 登録日 2017-09-22 公開日 2018-03-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.698 Å) 主引用文献 Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4QSH	Crystal Structure of L. monocytogenes Pyruvate Carboxylase in complex with Cyclic-di-AMP 分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CITRATE ANION, MANGANESE (II) ION, ... 著者 Choi, P.H, Tong, L. 登録日 2014-07-04 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function. Cell(Cambridge,Mass.), 158, 2014
5AJA	Crystal structure of mandrill SAMHD1 (amino acid residues 1-114) bound to Vpx isolated from mandrill and human DCAF1 (amino acid residues 1058-1396) 分子名称: PROTEIN VPRBP, SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN, VPX PROTEIN, ... 著者 Schwefel, D, Boucherit, V.C, Christodoulou, E, Walker, P.A, Stoye, J.P, Bishop, K.N, Taylor, I.A. 登録日 2015-02-20 公開日 2015-04-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.649 Å) 主引用文献 Molecular Determinants for Recognition of Divergent Samhd1 Proteins by the Lentiviral Accessory Protein Vpx. Cell Host Microbe., 17, 2015
5A51	The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions and phophatidyl serine 分子名称: AT3G17980, CALCIUM ION, PHOSPHOSERINE 著者 Diaz, M, Albert, A. 登録日 2015-06-16 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 Calcium-Dependent Oligomerization of Car Proteins at Cell Membrane Modulates Aba Signaling. Proc.Natl.Acad.Sci.USA, 113, 2016
5YQ4	Crystal structure of kelch domain of KLHL20 分子名称: Kelch-like protein 20 著者 Yeh, M.C, Ho, M.C. 登録日 2017-11-05 公開日 2018-11-14 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 The crystal structure of kelch domain of KLHL20 To Be Published
3FLQ	P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-((s)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin 分子名称: 6-(2,4-difluorophenoxy)-8-methyl-2-{[(1S)-1-methyl-2-(methylsulfonyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase 14 著者 Kuglstatter, A, Knapp, M. 登録日 2008-12-19 公開日 2009-12-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Discovery of Pamapimod, R1503 and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase To be Published

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