7N6N
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![BU of 7n6n by Molmil](/molmil-images/mine/7n6n) | SARS-CoV-2 Main protease C145S mutant in complex with N and C-terminal residues | 分子名称: | 3C-like proteinase | 著者 | Noske, G.D, Nakamura, A.M, Gawriljuk, V.O, Lima, G.M.A, Zeri, A.C.M, Nascimento, A.F.Z, Fernandes, R.S, Oliva, G, Godoy, A.S. | 登録日 | 2021-06-08 | 公開日 | 2021-06-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process. J.Mol.Biol., 433, 2021
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8ORL
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6UAO
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![BU of 6uao by Molmil](/molmil-images/mine/6uao) | Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with the peptide EEYSAM | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Peptide EEYSAM, ... | 著者 | Toth, E.A, Bryan, P.N, Orban, J. | 登録日 | 2019-09-11 | 公開日 | 2020-09-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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7UYQ
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![BU of 7uyq by Molmil](/molmil-images/mine/7uyq) | Structure of GTP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination | 分子名称: | Cyclic GMP-AMP synthase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Wu, S, Gabelli, S.B, Sohn, J. | 登録日 | 2022-05-07 | 公開日 | 2023-05-10 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS Nat Commun, 15, 2024
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6L2N
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![BU of 6l2n by Molmil](/molmil-images/mine/6l2n) | Crystal structure of the R.PabI(Y68F-K154A)-dsDNA(GTAC-3bp-GTAC) complex | 分子名称: | DNA (5'-D(*TP*CP*AP*GP*CP*AP*GP*TP*AP*CP*TP*AP*AP*GP*TP*AP*CP*TP*GP*CP*TP*GP*A)-3'), RE_R_Pab1 domain-containing protein | 著者 | Miyazono, K, Wang, D, Ito, T, Tanokura, M. | 登録日 | 2019-10-05 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Distortion of double-stranded DNA structure by the binding of the restriction DNA glycosylase R.PabI. Nucleic Acids Res., 48, 2020
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6TXD
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![BU of 6txd by Molmil](/molmil-images/mine/6txd) | Variant W229D/F290W-12 of the last common ancestor of Gram-negative bacteria beta-lactamase class A (GNCA4) | 分子名称: | ACETATE ION, Beta lactamase (GNCA4-12), FORMIC ACID, ... | 著者 | Gavira, J.A, Risso, V, Sanchez-Ruiz, J.M, Romero-Rivera, A, Kamerlin, S.C.L. | 登録日 | 2020-01-14 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Enhancing ade novoenzyme activity by computationally-focused ultra-low-throughput screening. Chem Sci, 11, 2020
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8BBB
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8OS3
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8OTY
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8BBZ
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6A5W
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![BU of 6a5w by Molmil](/molmil-images/mine/6a5w) | FXR-LBD with HNC143 and SRC1 | 分子名称: | 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1 | 著者 | Wang, N, Liu, J. | 登録日 | 2018-06-25 | 公開日 | 2018-10-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
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7UYX
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![BU of 7uyx by Molmil](/molmil-images/mine/7uyx) | Structure of bacteriophage PA1c gp2 | 分子名称: | Bacteriophage PA1C gp2 | 著者 | Enustun, E, Deep, A, Gu, Y, Nguyen, K, Chaikeeratisak, V, Armbruster, E, Ghassemian, M, Pogliano, J, Corbett, K.D. | 登録日 | 2022-05-07 | 公開日 | 2023-05-10 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Identification of the bacteriophage nucleus protein interaction network. Nat.Struct.Mol.Biol., 30, 2023
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7N50
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4ZDZ
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![BU of 4zdz by Molmil](/molmil-images/mine/4zdz) | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with fluconazole | 分子名称: | 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C. | 登録日 | 2015-04-20 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016
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7UYZ
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![BU of 7uyz by Molmil](/molmil-images/mine/7uyz) | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG | 分子名称: | Cyclic GMP-AMP synthase, GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Wu, S, Gabelli, S.B, Sohn, J. | 登録日 | 2022-05-07 | 公開日 | 2023-05-10 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS Nat Commun, 15, 2024
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8OT5
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![BU of 8ot5 by Molmil](/molmil-images/mine/8ot5) | Crystal structure of the titin domain Fn3-85 | 分子名称: | CHLORIDE ION, SODIUM ION, Titin | 著者 | Nikoopour, R, Rees, M, Gautel, M. | 登録日 | 2023-04-20 | 公開日 | 2023-08-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation. J.Struct.Biol., 215, 2023
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7RYO
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![BU of 7ryo by Molmil](/molmil-images/mine/7ryo) | CD1a-dideoxymycobactin-gdTCR complex | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, SULFATE ION, ... | 著者 | Wegrecki, M, Le Nours, J, Rossjohn, J. | 登録日 | 2021-08-25 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Atypical sideways recognition of CD1a by autoreactive gamma delta T cell receptors. Nat Commun, 13, 2022
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6L7V
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7V1A
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![BU of 7v1a by Molmil](/molmil-images/mine/7v1a) | Stapled TBS peptide from RIAM bound to talin R7R8 domains | 分子名称: | 1,2-ETHANEDIOL, ASP-ILE-ASP-GLN-MET-PHE-SER-THR-LEU-LEU-GLY-GLU-MK8-ASP-LEU-LEU-MK8-GLN-SER, Talin-1 | 著者 | Zhang, P, Gao, T, Wu, J. | 登録日 | 2022-05-11 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.845 Å) | 主引用文献 | Inhibition of talin-induced integrin activation by a double-hit stapled peptide. Structure, 31, 2023
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7NIG
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![BU of 7nig by Molmil](/molmil-images/mine/7nig) | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1008 | 分子名称: | 14-3-3 protein sigma, 2-bromanyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ... | 著者 | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | 登録日 | 2021-02-12 | 公開日 | 2021-06-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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7UZR
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![BU of 7uzr by Molmil](/molmil-images/mine/7uzr) | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG | 分子名称: | Cyclic GMP-AMP synthase, MANGANESE (II) ION, Palindromic DNA18, ... | 著者 | Wu, S, Gabelli, S.B, Sohn, J. | 登録日 | 2022-05-09 | 公開日 | 2023-05-10 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS Nat Commun, 15, 2024
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6L8F
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6UBR
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6ON0
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7V0C
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![BU of 7v0c by Molmil](/molmil-images/mine/7v0c) | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG | 分子名称: | Cyclic GMP-AMP synthase, MANGANESE (II) ION, Palindromic DNA18, ... | 著者 | Wu, S, Gabelli, S.B, Sohn, J. | 登録日 | 2022-05-10 | 公開日 | 2023-05-10 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG To Be Published
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