PDB: 56562 件ウェブページステータス検索Chemie searchBIRD

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6YAX	Crystal structure of CD32b (Fc Gamma Receptor IIb) in complex with Human IgG1 Fab fragment (5C05) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5C05 F(ab) heavy chain, ... 著者 Fisher, H, Tews, I, Orr, C. 登録日 2020-03-14 公開日 2021-10-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of CD32b (Fc Gamma Receptor IIb) in complex with Human IgG1 Fab fragment (5C05) To Be Published
7ZVF	Crystal structure of human cathepsin L in complex with covalently bound CLIK148 分子名称: (2S)-N-[(2S)-1-(dimethylamino)-1-oxidanylidene-3-phenyl-propan-2-yl]-2-oxidanyl-N'-(2-pyridin-2-ylethyl)butanediamide, 1,2-ETHANEDIOL, Cathepsin L, ... 著者 Falke, S, Lieske, J, Guenther, S, Reinke, P.Y.A, Ewert, W, Loboda, J, Karnicar, K, Usenik, A, Lindic, N, Sekirnik, A, Tsuge, H, Chapman, H.N, Hinrichs, W, Turk, D, Meents, A. 登録日 2022-05-15 公開日 2023-11-29 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67, 2024
6YD3	X-ray structure of furin in complex with the canavanine derived inhibitor 4-guanidinomethyl-phenylacetyl-Canavanine-Tle-Arg-Amba 分子名称: 4-guanidinomethyl-phenylacetyl-Canavanine-Tle-Arg-Amba, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2020-03-20 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin. Acs Med.Chem.Lett., 12, 2021
6LJM	Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P13 分子名称: 7-AMINO-4-METHYL-CHROMEN-2-ONE, ACE-SER-LEU-GLY-SLL, NAD-dependent protein deacylase sirtuin-5, ... 著者 Chen, Q, Yu, Y. 登録日 2019-12-17 公開日 2020-10-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery. Eur.J.Med.Chem., 192, 2020
7T21	E. coli DnaB bound to ssDNA and ADP-AlF4 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ... 著者 Oakley, A.J, Xu, Z.Q. 登録日 2021-12-02 公開日 2023-01-18 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (5.4 Å) 主引用文献 Sequence of conformation changes of DnaB helicase during DNA unwinding and priming in Escherichia coli To Be Published
6HOY	Human Sirt6 in complex with ADP-ribose and the inhibitor trichostatin A 分子名称: 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-6, SULFATE ION, ... 著者 You, W, Steegborn, C. 登録日 2018-09-18 公開日 2018-11-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development. J.Med.Chem., 61, 2018
7T23	E. coli DnaB bound to two DnaG C-terminal domains, ssDNA, ADP and AlF4 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA primase, ... 著者 Oakley, A.J, Xu, Z.Q. 登録日 2021-12-02 公開日 2023-01-18 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Sequence of conformation changes of DnaB helicase during DNA unwinding and priming in Escherichia coli To Be Published
7T22	E. coli DnaB bound to three DnaG C-terminal domains, ssDNA, ADP and AlF4 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA primase, ... 著者 Oakley, A.J, Xu, Z.Q. 登録日 2021-12-02 公開日 2023-01-18 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Sequence of conformation changes of DnaB helicase during DNA unwinding and priming in Escherichia coli To Be Published
6RNC	Liquid Application Method for time-resolved Analyses (LAMA) by serial synchrotron crystallography, Lysozyme with GlcNAc3 - 100ms diffusion time. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Lysozyme C, ... 著者 Mehrabi, P, Schulz, E.C, Miller, R.J.D. 登録日 2019-05-08 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Liquid application method for time-resolved analyses by serial synchrotron crystallography. Nat.Methods, 16, 2019
7TAY	Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone 分子名称: (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate, (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... 著者 Xia, D, Zhou, F, Esser, L. 登録日 2021-12-21 公開日 2023-01-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Conformation Switch of Rieske ISP subunit is revealed by the Crystal Structure of Bacterial Cytochrome bc1 in Complex with Azoxystrobin to be published
6RM9	Crystal structure of the DEAH-box ATPase Prp2 in complex with Spp2 and ADP 分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... 著者 Hamann, F, Neumann, P, Ficner, R. 登録日 2019-05-06 公開日 2020-02-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proc.Natl.Acad.Sci.USA, 117, 2020
6RNB	Liquid Application Method for time-resolved Analyses (LAMA) by serial synchrotron crystallography, Lysozyme with GlcNAc3 50ms diffusion time 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Lysozyme C, ... 著者 Mehrabi, P, Schulz, E.C, Miller, R.J.D. 登録日 2019-05-08 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Liquid application method for time-resolved analyses by serial synchrotron crystallography. Nat.Methods, 16, 2019
7SPQ	Crystal structure of Burkholderia glumae toxoflavin biosynthesis protein ToxD 分子名称: CALCIUM ION, CITRIC ACID, PENTAETHYLENE GLYCOL, ... 著者 Fenwick, M.K, Philmus, B, Ealick, S.E. 登録日 2021-11-03 公開日 2023-05-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of Burkholderia glumae toxoflavin biosynthesis protein ToxD To Be Published
8Q3L	Human Gamma-D Crystallin R36S fresh serial crystallographic structure 分子名称: Gamma-crystallin D 著者 Yorke, B.A, Hill, J.A. 登録日 2023-08-04 公開日 2024-04-17 最終更新日 2024-08-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin. Commun Chem, 7, 2024
5IX0	HDAC2 WITH LIGAND BRD7232 分子名称: (3-exo)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-8-oxabicyclo[3.2.1]octane-3-carboxamide, 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ... 著者 Steinbacher, S. 登録日 2016-03-23 公開日 2016-08-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
1AFC	STRUCTURAL STUDIES OF THE BINDING OF THE ANTI-ULCER DRUG SUCROSE OCTASULFATE TO ACIDIC FIBROBLAST GROWTH FACTOR 分子名称: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACIDIC FIBROBLAST GROWTH FACTOR 著者 Zhu, X, Hsu, B.T, Rees, D.C. 登録日 1993-07-13 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor. Structure, 1, 1993
5IWG	HDAC2 WITH LIGAND BRD4884 分子名称: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Steinbacher, S. 登録日 2016-03-22 公開日 2016-08-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
5LPK	Crystal structure of the bromodomain of human EP300 bound to the inhibitor XDM1 分子名称: 1,2-ETHANEDIOL, Histone acetyltransferase p300, SULFATE ION, ... 著者 Huegle, M, Wohlwend, D. 登録日 2016-08-13 公開日 2017-08-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56, 2017
6HKR	Human Cellular Retinoic Acid Binding Protein II (CRABPII) with bound synthetic retinoid DC271. 分子名称: 1,2-ETHANEDIOL, 4-[2-(4,4-dimethyl-1-propan-2-yl-2,3-dihydroquinolin-6-yl)ethynyl]benzoic acid, Cellular retinoic acid-binding protein 2, ... 著者 Tomlinson, C, Chisholm, D, Whiting, A, Pohl, E. 登録日 2018-09-07 公開日 2018-11-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Novel Fluorescence Competition Assay for Retinoic Acid Binding Proteins. ACS Med Chem Lett, 9, 2018
6RMB	Crystal structure of the DEAH-box ATPase Prp2 in complex with Spp2 and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative mRNA splicing factor, ... 著者 Hamann, F, Neumann, P, Ficner, R. 登録日 2019-05-06 公開日 2020-02-05 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proc.Natl.Acad.Sci.USA, 117, 2020
5J5Y	Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog 分子名称: 2-amino-9-{5-O-[(R)-{[(S)-{dichloro[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-O-methyl-beta-D-ribofuranosyl}-7-methyl-9H-purin-7-ium-6-olate, Eukaryotic translation initiation factor 4E, GLYCEROL 著者 Warminski, M, Nowak, E, Rydzik, A.M, Kowalska, J, Jemielity, J, Nowotny, M. 登録日 2016-04-04 公開日 2017-05-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Nucleic Acids Res., 45, 2017
5LK4	Structure of the Red Fluorescent Protein mScarlet at pH 7.8 分子名称: DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, TETRAETHYLENE GLYCOL, ... 著者 Aumonier, S, Gotthard, G, Royant, A. 登録日 2016-07-20 公開日 2016-12-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 mScarlet: a bright monomeric red fluorescent protein for cellular imaging. Nat. Methods, 14, 2017
5LYP	Crystal structure of the Tpr Domain of Sgt2. 分子名称: BORATE ION, Small glutamine-rich tetratricopeptide repeat-containing protein 2 著者 Krysztofinska, E.M, Morgan, R.M.L, Thapaliya, A, Evans, N.J, Murray, J.W, Martinez-Lumbreras, S, Isaacson, R.L. 登録日 2016-09-28 公開日 2017-10-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp. Front Mol Biosci, 4, 2017
7TQ7	Structure of MERS 3CL protease in complex with the cyclopropane based inhibitor 13c 分子名称: N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-({[(1R,2R)-2-propylcyclopropyl]methoxy}carbonyl)-L-leucinamide, Orf1a protein, TETRAETHYLENE GLYCOL 著者 Lovell, S, Liu, L, Battaile, K.P, Nguyen, H.N, Chamandi, S.D, Picard, H.R, Madden, T.K, Thruman, H.A, Kim, Y, Groutas, W.C, Chang, K.O. 登録日 2022-01-26 公開日 2022-02-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies. Acs Pharmacol Transl Sci, 6, 2023
5LZ9	Fragment-based inhibitors of Lipoprotein associated Phospholipase A2 分子名称: 2-fluoranyl-5-[2-[(4~{S})-4-[4-methyl-1,1-bis(oxidanylidene)thian-4-yl]-2-oxidanylidene-pyrrolidin-1-yl]ethoxy]benzenecarbonitrile, CHLORIDE ION, Platelet-activating factor acetylhydrolase, ... 著者 Woolford, A, Day, P. 登録日 2016-09-29 公開日 2016-12-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J. Med. Chem., 59, 2016

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