6HOY
Human Sirt6 in complex with ADP-ribose and the inhibitor trichostatin A
Summary for 6HOY
Entry DOI | 10.2210/pdb6hoy/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (8 entities in total) |
Functional Keywords | deacylase, inhibitor, hydroxamate, non-competitive, isoform-selective, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70364.47 |
Authors | You, W.,Steegborn, C. (deposition date: 2018-09-18, release date: 2018-11-14, Last modification date: 2024-01-24) |
Primary citation | You, W.,Steegborn, C. Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development. J.Med.Chem., 61:10922-10928, 2018 Cited by PubMed: 30395713DOI: 10.1021/acs.jmedchem.8b01455 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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