6HOY
Human Sirt6 in complex with ADP-ribose and the inhibitor trichostatin A
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | binding site for residue AR6 A 401 |
Chain | Residue |
A | GLY52 |
A | HIS133 |
A | GLY214 |
A | THR215 |
A | SER216 |
A | ILE219 |
A | ASN240 |
A | LEU241 |
A | GLN242 |
A | GLY256 |
A | TYR257 |
A | ALA53 |
A | VAL258 |
A | PG4403 |
A | HOH530 |
A | HOH544 |
A | HOH560 |
A | HOH561 |
A | HOH583 |
B | ASP83 |
B | HOH843 |
A | GLY54 |
A | THR57 |
A | ASP63 |
A | PHE64 |
A | ARG65 |
A | TRP71 |
A | GLN113 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 402 |
Chain | Residue |
A | CYS141 |
A | CYS144 |
A | CYS166 |
A | CYS177 |
site_id | AC3 |
Number of Residues | 9 |
Details | binding site for residue PG4 A 403 |
Chain | Residue |
A | LEU186 |
A | ASP187 |
A | TRP188 |
A | ASP190 |
A | LEU192 |
A | ILE219 |
A | ARG220 |
A | AR6401 |
A | HOH520 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue EDO A 404 |
Chain | Residue |
A | ASP151 |
A | PRO293 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 405 |
Chain | Residue |
A | GLU29 |
A | LYS33 |
A | ARG253 |
A | HIS255 |
A | HOH562 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 406 |
Chain | Residue |
A | ARG231 |
A | ARG232 |
A | HOH581 |
B | ARG205 |
B | ARG232 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 407 |
Chain | Residue |
A | ARG220 |
A | PRO221 |
A | ASN224 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue SO4 A 408 |
Chain | Residue |
A | ARG90 |
A | ALA275 |
A | TRP276 |
A | HOH550 |
B | ARG90 |
B | ALA275 |
B | TRP276 |
site_id | AC9 |
Number of Residues | 10 |
Details | binding site for residue TSN A 409 |
Chain | Residue |
A | ALA53 |
A | SER56 |
A | ILE61 |
A | PRO62 |
A | PHE64 |
A | TRP71 |
A | ASN114 |
A | VAL115 |
A | ASP116 |
A | HOH549 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue EDO B 701 |
Chain | Residue |
A | HOH612 |
B | TYR257 |
site_id | AD2 |
Number of Residues | 28 |
Details | binding site for residue AR6 B 702 |
Chain | Residue |
B | HOH850 |
B | HOH855 |
B | HOH857 |
B | HOH912 |
A | ASP83 |
B | GLY52 |
B | ALA53 |
B | GLY54 |
B | THR57 |
B | ASP63 |
B | PHE64 |
B | ARG65 |
B | TRP71 |
B | GLN113 |
B | HIS133 |
B | GLY214 |
B | THR215 |
B | SER216 |
B | ILE219 |
B | ASN240 |
B | LEU241 |
B | GLN242 |
B | GLY256 |
B | TYR257 |
B | VAL258 |
B | PG4704 |
B | HOH805 |
B | HOH825 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue ZN B 703 |
Chain | Residue |
B | CYS141 |
B | CYS144 |
B | CYS166 |
B | CYS177 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue PG4 B 704 |
Chain | Residue |
B | LEU186 |
B | TRP188 |
B | ASP190 |
B | ARG220 |
B | AR6702 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue EDO B 705 |
Chain | Residue |
B | ASP151 |
B | PRO292 |
B | PRO293 |
B | HOH823 |
B | HOH845 |
site_id | AD6 |
Number of Residues | 9 |
Details | binding site for residue SO4 B 706 |
Chain | Residue |
A | HIS68 |
A | HOH573 |
B | HIS68 |
B | LYS81 |
B | HOH828 |
B | HOH830 |
B | HOH865 |
B | HOH879 |
B | HOH885 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 707 |
Chain | Residue |
B | LYS33 |
B | ARG253 |
B | HIS255 |
B | HOH881 |
site_id | AD8 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 708 |
Chain | Residue |
B | ARG220 |
B | PRO221 |
B | ASN224 |
site_id | AD9 |
Number of Residues | 10 |
Details | binding site for residue TSN B 709 |
Chain | Residue |
B | ALA53 |
B | SER56 |
B | PRO62 |
B | VAL70 |
B | TRP71 |
B | GLU74 |
B | ASN114 |
B | VAL115 |
B | ASP116 |
B | HOH862 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:18337721, ECO:0000305|PubMed:23552949, ECO:0000305|PubMed:23892288, ECO:0000305|PubMed:27322069, ECO:0000305|PubMed:28406396 |
Chain | Residue | Details |
A | HIS133 | |
B | HIS133 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:21362626, ECO:0007744|PDB:3K35, ECO:0007744|PDB:3ZG6 |
Chain | Residue | Details |
A | ALA53 | |
B | ALA53 |
site_id | SWS_FT_FI3 |
Number of Residues | 22 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23552949, ECO:0000305|PubMed:21362626, ECO:0007744|PDB:3K35, ECO:0007744|PDB:3ZG6 |
Chain | Residue | Details |
A | ARG65 | |
A | TRP71 | |
A | GLN113 | |
A | HIS133 | |
A | GLY214 | |
A | SER216 | |
A | ASN240 | |
A | GLN242 | |
A | VAL258 | |
B | THR57 | |
B | PHE64 | |
B | ARG65 | |
B | TRP71 | |
B | GLN113 | |
B | HIS133 | |
B | GLY214 | |
B | SER216 | |
B | ASN240 | |
B | GLN242 | |
B | VAL258 | |
A | THR57 | |
A | PHE64 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:21362626, ECO:0000269|PubMed:23552949, ECO:0000269|PubMed:27990725, ECO:0007744|PDB:3K35, ECO:0007744|PDB:3PKI, ECO:0007744|PDB:3PKJ, ECO:0007744|PDB:3ZG6, ECO:0007744|PDB:5MF6, ECO:0007744|PDB:5MFP, ECO:0007744|PDB:5MFZ, ECO:0007744|PDB:5MGN |
Chain | Residue | Details |
A | CYS166 | |
A | CYS177 | |
B | CYS141 | |
B | CYS144 | |
B | CYS166 | |
B | CYS177 | |
A | CYS141 | |
A | CYS144 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Formation of an covalent adduct with nitro-fatty acid activators => ECO:0000269|PubMed:33122195 |
Chain | Residue | Details |
A | CYS18 | |
B | CYS18 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:32538779 |
Chain | Residue | Details |
A | LYS33 | |
B | LYS33 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | THR294 | |
B | THR294 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER303 | |
B | SER303 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24043303 |
Chain | Residue | Details |
B | LYS170 | |
A | LYS170 |