6HOY
Human Sirt6 in complex with ADP-ribose and the inhibitor trichostatin A
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | binding site for residue AR6 A 401 |
Chain | Residue |
A | GLY52 |
A | HIS133 |
A | GLY214 |
A | THR215 |
A | SER216 |
A | ILE219 |
A | ASN240 |
A | LEU241 |
A | GLN242 |
A | GLY256 |
A | TYR257 |
A | ALA53 |
A | VAL258 |
A | PG4403 |
A | HOH530 |
A | HOH544 |
A | HOH560 |
A | HOH561 |
A | HOH583 |
B | ASP83 |
B | HOH843 |
A | GLY54 |
A | THR57 |
A | ASP63 |
A | PHE64 |
A | ARG65 |
A | TRP71 |
A | GLN113 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 402 |
Chain | Residue |
A | CYS141 |
A | CYS144 |
A | CYS166 |
A | CYS177 |
site_id | AC3 |
Number of Residues | 9 |
Details | binding site for residue PG4 A 403 |
Chain | Residue |
A | LEU186 |
A | ASP187 |
A | TRP188 |
A | ASP190 |
A | LEU192 |
A | ILE219 |
A | ARG220 |
A | AR6401 |
A | HOH520 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue EDO A 404 |
Chain | Residue |
A | ASP151 |
A | PRO293 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 405 |
Chain | Residue |
A | GLU29 |
A | LYS33 |
A | ARG253 |
A | HIS255 |
A | HOH562 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 406 |
Chain | Residue |
A | ARG231 |
A | ARG232 |
A | HOH581 |
B | ARG205 |
B | ARG232 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 407 |
Chain | Residue |
A | ARG220 |
A | PRO221 |
A | ASN224 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue SO4 A 408 |
Chain | Residue |
A | ARG90 |
A | ALA275 |
A | TRP276 |
A | HOH550 |
B | ARG90 |
B | ALA275 |
B | TRP276 |
site_id | AC9 |
Number of Residues | 10 |
Details | binding site for residue TSN A 409 |
Chain | Residue |
A | ALA53 |
A | SER56 |
A | ILE61 |
A | PRO62 |
A | PHE64 |
A | TRP71 |
A | ASN114 |
A | VAL115 |
A | ASP116 |
A | HOH549 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue EDO B 701 |
Chain | Residue |
A | HOH612 |
B | TYR257 |
site_id | AD2 |
Number of Residues | 28 |
Details | binding site for residue AR6 B 702 |
Chain | Residue |
B | HOH850 |
B | HOH855 |
B | HOH857 |
B | HOH912 |
A | ASP83 |
B | GLY52 |
B | ALA53 |
B | GLY54 |
B | THR57 |
B | ASP63 |
B | PHE64 |
B | ARG65 |
B | TRP71 |
B | GLN113 |
B | HIS133 |
B | GLY214 |
B | THR215 |
B | SER216 |
B | ILE219 |
B | ASN240 |
B | LEU241 |
B | GLN242 |
B | GLY256 |
B | TYR257 |
B | VAL258 |
B | PG4704 |
B | HOH805 |
B | HOH825 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue ZN B 703 |
Chain | Residue |
B | CYS141 |
B | CYS144 |
B | CYS166 |
B | CYS177 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue PG4 B 704 |
Chain | Residue |
B | LEU186 |
B | TRP188 |
B | ASP190 |
B | ARG220 |
B | AR6702 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue EDO B 705 |
Chain | Residue |
B | ASP151 |
B | PRO292 |
B | PRO293 |
B | HOH823 |
B | HOH845 |
site_id | AD6 |
Number of Residues | 9 |
Details | binding site for residue SO4 B 706 |
Chain | Residue |
A | HIS68 |
A | HOH573 |
B | HIS68 |
B | LYS81 |
B | HOH828 |
B | HOH830 |
B | HOH865 |
B | HOH879 |
B | HOH885 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 707 |
Chain | Residue |
B | LYS33 |
B | ARG253 |
B | HIS255 |
B | HOH881 |
site_id | AD8 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 708 |
Chain | Residue |
B | ARG220 |
B | PRO221 |
B | ASN224 |
site_id | AD9 |
Number of Residues | 10 |
Details | binding site for residue TSN B 709 |
Chain | Residue |
B | ALA53 |
B | SER56 |
B | PRO62 |
B | VAL70 |
B | TRP71 |
B | GLU74 |
B | ASN114 |
B | VAL115 |
B | ASP116 |
B | HOH862 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 18 |
Details | Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18337721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23892288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27322069","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28406396","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"21362626","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3K35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZG6","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 22 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21362626","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3K35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZG6","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21362626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27990725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3K35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PKJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MF6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MGN","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | Site: {"description":"Formation of an covalent adduct with nitro-fatty acid activators","evidences":[{"source":"PubMed","id":"33122195","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"32538779","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |