PDB: 55698 件ウェブページステータス検索Chemie searchBIRD

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4YLQ	Crystal Structure of a FVIIa-Trypsin Chimera (FT) in Complex with Soluble Tissue Factor 分子名称: CALCIUM ION, Coagulation factor VII, N-PROPANOL, ... 著者 Sorensen, A.B, Svensson, L.A, Gandhi, P.S. 登録日 2015-03-05 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity. J.Biol.Chem., 291, 2016
8OT7	Crystal structure of an 8-repeat consensus TPR superhelix with Barium 分子名称: BARIUM ION, Consensus tetratricopeptide repeat protein 著者 Liutkus, M, Rojas, A.L, Cortajarena, A.L. 登録日 2023-04-20 公開日 2024-04-24 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Diverse crystalline protein scaffolds through metal-dependent polymorphism. Protein Sci., 33, 2024
5K0I	mpges1 bound to an inhibitor 分子名称: 1,5-anhydro-2,3,4-trideoxy-3-{[(4S)-3,3-dimethyl-1-(8-methylquinolin-2-yl)piperidine-4-carbonyl]amino}-D-erythro-hexitol, GLUTATHIONE, Prostaglandin E synthase, ... 著者 Luz, J.G, Kuklish, S.L. 登録日 2016-05-17 公開日 2016-09-14 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
6O9E	Structure of HIV-1 Reverse Transcriptase in complex with DNA and INDOPY-1 分子名称: 5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Ruiz, F.X, Hoang, A, Das, K, Arnold, E. 登録日 2019-03-13 公開日 2019-10-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1. J.Med.Chem., 62, 2019
8C77	Human cathepsin L after reaction with the thiocarbazate inhibitor CID 16725315 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Cathepsin L, ... 著者 Falke, S, Lieske, J, Guenther, S, Reinke, P.Y.A, Ewert, W, Loboda, J, Karnicar, K, Usenik, A, Lindic, N, Sekirnik, A, Chapman, H.N, Hinrichs, W, Turk, D, Meents, A. 登録日 2023-01-12 公開日 2023-01-25 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67, 2024
4YL3	Crystal Structures of mPGES-1 Inhibitor Complexes 分子名称: 5-[4-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-5-yl]-2-{[4-(trifluoromethyl)phenyl]ethynyl}pyridine, GLUTATHIONE, Prostaglandin E synthase, ... 著者 Luz, J.G, Antonysamy, S, Kuklish, S.L, Fisher, M.J. 登録日 2015-03-04 公開日 2015-07-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics. J.Med.Chem., 58, 2015
7UQB	Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1-D52A strain with AlF4 分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... 著者 Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. 登録日 2022-04-19 公開日 2023-03-15 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.43 Å) 主引用文献 rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
8P1G	Crystal structure of inactive TtCE16 in complex with acetate 分子名称: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dimarogona, M, Kosinas, C, Pentari, C, Zerva, A, Topakas, E, Karampa, P. 登録日 2023-05-12 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 The role of CE16 exo-deacetylases in hemicellulolytic enzyme mixtures revealed by the biochemical and structural study of the novel TtCE16B esterase. Carbohydr Polym, 327, 2024
8OTH	TypeII tau filament from Kii ALS/PDC 分子名称: Microtubule-associated protein tau 著者 Qi, C, Yang, S, Scheres, S.H.W, Goedert, M. 登録日 2023-04-20 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
7UIB	Crystal structure of BoNT/E receptor binding domain in complex with SV2, VHH, and sialic acid 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-beta-neuraminic acid, ... 著者 Liu, Z, Jin, R, Chen, P. 登録日 2022-03-29 公開日 2023-04-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2. Nat Commun, 14, 2023
5L7X	Afamin antibody fragment, N14 Fab, L1- glycosylated, crystal form II 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, Mouse Antibody Fab Fragment, ... 著者 Rupp, B, Naschberger, A. 登録日 2016-06-04 公開日 2016-07-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling. Acta Crystallogr D Struct Biol, 72, 2016
8OTG	CTE typeI tau filament from Kii ALS/PDC 分子名称: Microtubule-associated protein tau 著者 Qi, C, Yang, S, Scheres, S.H.W, Goedert, M. 登録日 2023-04-20 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
6O5I	Menin in complex with MI-3454 分子名称: DIMETHYL SULFOXIDE, Menin, SULFATE ION, ... 著者 Linhares, B.M, Klossowski, S, Cierpicki, T, Grembecka, J. 登録日 2019-03-03 公開日 2020-01-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.24025619 Å) 主引用文献 Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J.Clin.Invest., 130, 2020
4H7Y	Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1 分子名称: Dual specificity protein kinase TTK 著者 Bolanos-Garcia, V.M, Chirgadze, D.Y, Blundell, T.L. 登録日 2012-09-21 公開日 2012-12-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem.J., 448, 2012
7UBA	Structure of fungal Hop1 CBR domain 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HORMA domain-containing protein, PENTAETHYLENE GLYCOL, ... 著者 Ur, S.N, Corbett, K.D. 登録日 2022-03-14 公開日 2023-03-29 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.599 Å) 主引用文献 Chromatin binding by HORMAD proteins regulates meiotic recombination initiation. Embo J., 43, 2024
4TY6	Factor XIa in complex with the inhibitor 4-{2-[(1S)-1-({[trans-4-(aminomethyl)cyclohexyl]carbonyl}amino)-2-phenylethyl]-1H-imidazol-4-yl}benzamide 分子名称: 1,2-ETHANEDIOL, 4-{2-[(1S)-1-({[trans-4-(aminomethyl)cyclohexyl]carbonyl}amino)-2-phenylethyl]-1H-imidazol-4-yl}benzamide, CYS-THR-THR-LYS-ILE-LYS-PRO, ... 著者 Wei, A. 登録日 2014-07-07 公開日 2014-12-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity. J.Med.Chem., 57, 2014
4Z4Y	Crystal structure of GII.10 P domain in complex with 7.5mM B antigen (trisaccharide) 分子名称: 1,2-ETHANEDIOL, Capsid protein, alpha-L-fucopyranose-(1-2)-[alpha-D-galactopyranose-(1-3)]alpha-D-galactopyranose 著者 Leuthold, M.M, Koromyslova, A.D, Hansman, G.S. 登録日 2015-04-02 公開日 2015-05-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.797 Å) 主引用文献 The sweet quartet: Binding of fucose to the norovirus capsid. Virology, 483, 2015
4U07	ATP bound to eukaryotic FIC domain containing protein 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Adenosine monophosphate-protein transferase FICD, MAGNESIUM ION, ... 著者 Cole, A.R, Bunney, T.D, Katan, M. 登録日 2014-07-11 公開日 2014-12-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions. Structure, 22, 2014
6OCA	Ricin A chain bound to VHH antibody V2G10 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Ricin A chain, ... 著者 Rudolph, M.J. 登録日 2019-03-22 公開日 2020-04-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.113 Å) 主引用文献 Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site. J.Mol.Biol., 432, 2020
8OTC	CTE typeII tau filament from Guam ALS/PDC 分子名称: Microtubule-associated protein tau 著者 Qi, C, Yang, S, Scheres, S.H.W, Goedert, M. 登録日 2023-04-20 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
8OTF	Ab typeII filament from Guam ALS/PDC 分子名称: Amyloid-beta precursor protein 著者 Qi, C, Yang, S, Scheres, S.H.W, Goedert, M. 登録日 2023-04-20 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
8OTE	TMEM106B Fold I-d filament from Guam ALS/PDC 分子名称: Transmembrane protein 106B 著者 Qi, C, Yang, S, Scheres, S.H.W, Goedert, M. 登録日 2023-04-20 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
8OT6	CTE typeI tau filament from Guam ALS/PDC 分子名称: Microtubule-associated protein tau 著者 Qi, C, Yang, S, Scheres, S.H.W, Goedert, M. 登録日 2023-04-20 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2 Å) 主引用文献 Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
8OTJ	PHF tau filament from Kii ALS/PDC 分子名称: Microtubule-associated protein tau 著者 Qi, C, Yang, S, Scheres, S.H.W, Goedert, M. 登録日 2023-04-20 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
7ULL	Human Grp94 N-terminal domain in complex with 42C 分子名称: DIMETHYL SULFOXIDE, Endoplasmin, GLYCEROL, ... 著者 Stachowski, T.R, Nithianantham, S, Vanarotti, M, Fischer, M. 登録日 2022-04-05 公開日 2023-04-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Pan-HSP90 ligand binding reveals isoform-specific differences in plasticity and water networks. Protein Sci., 32, 2023

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