8C77

Human cathepsin L after reaction with the thiocarbazate inhibitor CID 16725315

Summary for 8C77

Entry DOI	10.2210/pdb8c77/pdb
Related	7QKD
Descriptor	Cathepsin L, ~{tert}-butyl ~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(2-methanoylhydrazinyl)-1-oxidanylidene-propan-2-yl]carbamate, 1,2-ETHANEDIOL, ... (9 entities in total)
Functional Keywords	cystein protease, drug target, lysosome, virus cell entry, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	100340.01
Authors	Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2023-01-12, release date: 2023-01-25, Last modification date: 2024-05-22)
Primary citation	Falke, S.,Lieske, J.,Herrmann, A.,Loboda, J.,Karnicar, K.,Gunther, S.,Reinke, P.Y.A.,Ewert, W.,Usenik, A.,Lindic, N.,Sekirnik, A.,Dretnik, K.,Tsuge, H.,Turk, V.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A. Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67:7048-7067, 2024 Cited by PubMed: 38630165 DOI: 10.1021/acs.jmedchem.3c02351 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation