6TA4
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![BU of 6ta4 by Molmil](/molmil-images/mine/6ta4) | Human kinesin-5 motor domain in the AMPPNP state bound to microtubules | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ... | 著者 | Pena, A.P, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | 登録日 | 2019-10-29 | 公開日 | 2020-03-04 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure, 28, 2020
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1O83
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![BU of 1o83 by Molmil](/molmil-images/mine/1o83) | Crystal Structure of Bacteriocin AS-48 at pH 7.5, phosphate bound. Crystal form I | 分子名称: | GLYCEROL, PEPTIDE ANTIBIOTIC AS-48, PHOSPHATE ION | 著者 | Sanchez-Barrena, M.J, Martinez-Ripoll, M, Galvez, A, Valdivia, E, Maqueda, M, Cruz, V, Albert, A. | 登録日 | 2002-11-25 | 公開日 | 2003-11-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Structure of Bacteriocin as-48: From Soluble State to Membrane Bound State J.Mol.Biol., 334, 2003
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6T7C
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![BU of 6t7c by Molmil](/molmil-images/mine/6t7c) | Structure of two copies of human Sox11 transcription factor in complex with a nucleosome | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. | 登録日 | 2019-10-21 | 公開日 | 2020-04-29 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature, 580, 2020
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6TG4
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![BU of 6tg4 by Molmil](/molmil-images/mine/6tg4) | Tankyrase 2 in complex with an inhibitor (OM-1700) | 分子名称: | N-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]pyridine-2-carboxamide, Tankyrase-2, ZINC ION | 著者 | Sowa, S.T, Lehtio, L. | 登録日 | 2019-11-15 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor. J.Med.Chem., 63, 2020
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4YJ5
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![BU of 4yj5 by Molmil](/molmil-images/mine/4yj5) | Crystal structure of PKM2 mutant | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, PYRUVIC ACID, ... | 著者 | Liu, J.-S, Wu, C.-W, Wang, W.-C. | 登録日 | 2015-03-03 | 公開日 | 2016-03-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation Commun Biol, 2, 2019
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6T7A
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![BU of 6t7a by Molmil](/molmil-images/mine/6t7a) | Structure of human Sox11 transcription factor in complex with a nucleosome | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. | 登録日 | 2019-10-21 | 公開日 | 2020-04-29 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature, 580, 2020
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6T7B
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![BU of 6t7b by Molmil](/molmil-images/mine/6t7b) | Structure of human Sox2 transcription factor in complex with a nucleosome | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. | 登録日 | 2019-10-21 | 公開日 | 2020-04-29 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | 主引用文献 | Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature, 580, 2020
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6T9K
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![BU of 6t9k by Molmil](/molmil-images/mine/6t9k) | SAGA Core module | 分子名称: | Protein SPT3, SAGA-associated factor 73, Transcription factor SPT20, ... | 著者 | Wang, H, Cheung, A, Cramer, P. | 登録日 | 2019-10-28 | 公開日 | 2020-01-29 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the transcription coactivator SAGA. Nature, 577, 2020
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4YUB
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![BU of 4yub by Molmil](/molmil-images/mine/4yub) | |
6TKQ
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![BU of 6tkq by Molmil](/molmil-images/mine/6tkq) | Tankyrase 2 in complex with an inhibitor (OM-2700) | 分子名称: | Tankyrase-2, ZINC ION, ~{N}-[3-[5-(5-ethoxypyridin-2-yl)-4-phenyl-1,2,4-triazol-3-yl]cyclobutyl]-1,5-naphthyridine-4-carboxamide | 著者 | Sowa, S.T, Lehtio, L. | 登録日 | 2019-11-28 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor. J.Med.Chem., 63, 2020
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6TCA
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![BU of 6tca by Molmil](/molmil-images/mine/6tca) | Phosphorylated p38 and MAPKAPK2 complex with inhibitor | 分子名称: | MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | 著者 | Sok, P, Remenyi, A. | 登録日 | 2019-11-05 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases. Structure, 28, 2020
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4YPU
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![BU of 4ypu by Molmil](/molmil-images/mine/4ypu) | ASH1L SET domain K2264L mutant in complex with S-adenosyl methionine (SAM) | 分子名称: | Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION | 著者 | Rogawski, D.S, Ndoj, J, Cho, H.J, Maillard, I, Grembecka, J, Cierpicki, T. | 登録日 | 2015-03-13 | 公開日 | 2015-09-02 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. Biochemistry, 54, 2015
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7TRB
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![BU of 7trb by Molmil](/molmil-images/mine/7trb) | CRYSTAL STRUCTURE OF FARNESOID X-ACTIVATED RECEPTOR COMPLEXED WITH COMPOUND-32 AKA (1S,3S)-N-({4-[5-(2-FLUOROPR OPAN-2-YL)-1,2,4-OXADIAZOL-3-YL]BICYCLO[2.2.2]OCTAN-1-YL}M ETHYL)-3-HYDROXY-N-[4'-(2-HYDROXYPROPAN-2-YL)-[1,1'-BIPHEN YL]-3-YL]-3-(TRIFLUOROMETHYL)CYCLOBUTANE-1-CARBOXAMIDE | 分子名称: | (1s,3s)-N-({4-[5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl]bicyclo[2.2.2]octan-1-yl}methyl)-3-hydroxy-N-[4'-(2-hydroxypropan-2-yl)[1,1'-biphenyl]-3-yl]-3-(trifluoromethyl)cyclobutane-1-carboxamide, Bile acid receptor, co-activator | 著者 | Khan, J.A, Ruzanov, M. | 登録日 | 2022-01-28 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis. J.Med.Chem., 65, 2022
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7TY3
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![BU of 7ty3 by Molmil](/molmil-images/mine/7ty3) | Crystal Structure of SETD2 Bound to an Indole-based Inhibitor | 分子名称: | 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETD2, N-[(1R,3R)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide, ... | 著者 | Farrow, N.A. | 登録日 | 2022-02-11 | 公開日 | 2022-08-31 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies. Acs Med.Chem.Lett., 13, 2022
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7TY2
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![BU of 7ty2 by Molmil](/molmil-images/mine/7ty2) | Crystal Structure of SETD2 Bound to an Indole-based Inhibitor | 分子名称: | Histone-lysine N-methyltransferase SETD2, N-[(1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide, S-ADENOSYLMETHIONINE, ... | 著者 | Farrow, N.A. | 登録日 | 2022-02-11 | 公開日 | 2022-08-31 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.438 Å) | 主引用文献 | Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies. Acs Med.Chem.Lett., 13, 2022
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6B42
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1OW8
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![BU of 1ow8 by Molmil](/molmil-images/mine/1ow8) | Paxillin LD2 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase | 分子名称: | Focal adhesion kinase 1, Paxillin | 著者 | Hoellerer, M.K, Noble, M.E.M, Labesse, G, Werner, J.M, Arold, S.T. | 登録日 | 2003-03-28 | 公開日 | 2003-10-21 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Molecular Recognition of Paxillin LD Motifs
by the Focal Adhesion Targeting Domain Structure, 11, 2003
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6CBI
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![BU of 6cbi by Molmil](/molmil-images/mine/6cbi) | PCNA in complex with inhibitor | 分子名称: | GLY-ARG-LYS-ARG-ARG-GLN-DAB-SER-MET-THR-GLU-PHE-TYR-HIS, Proliferating cell nuclear antigen, SULFATE ION | 著者 | Bruning, J.B, Wegener, K.L. | 登録日 | 2018-02-03 | 公開日 | 2018-07-04 | 最終更新日 | 2020-01-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp. Chemistry, 24, 2018
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6CCD
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![BU of 6ccd by Molmil](/molmil-images/mine/6ccd) | |
6CF6
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![BU of 6cf6 by Molmil](/molmil-images/mine/6cf6) | RNF146 TBM-Tankyrase ARC2-3 complex | 分子名称: | RNF146, Tankyrase-1 | 著者 | Da Rosa, P.A, Xu, W. | 登録日 | 2018-02-13 | 公開日 | 2018-04-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs. Protein Sci., 27, 2018
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6T9L
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6TA3
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![BU of 6ta3 by Molmil](/molmil-images/mine/6ta3) | Human kinesin-5 motor domain in the GSK-1 state bound to microtubules (Conformation 1) | 分子名称: | 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ... | 著者 | Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | 登録日 | 2019-10-29 | 公開日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure, 28, 2020
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1MQZ
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![BU of 1mqz by Molmil](/molmil-images/mine/1mqz) | NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles | 分子名称: | LANTIBIOTIC MERSACIDIN | 著者 | Hsu, S.-T, Breukink, E, Bierbaum, G, Sahl, H.-G, de Kruijff, B, Kaptein, R, van Nuland, N.A, Bonvin, A.M. | 登録日 | 2002-09-17 | 公開日 | 2003-03-11 | 最終更新日 | 2024-07-10 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Study of Mersacidin and Lipid II Interaction in Dodecylphosphocholine Micelles. Conformational Changes are a Key to Antimicrobial Activity J.Biol.Chem., 278, 2003
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1MQY
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![BU of 1mqy by Molmil](/molmil-images/mine/1mqy) | NMR solution structure of type-B lantibiotics mersacidin in DPC micelles | 分子名称: | LANTIBIOTIC MERSACIDIN | 著者 | Hsu, S.-T, Breukink, E, Bierbaum, G, Sahl, H.-G, de Kruijff, B, Kaptein, R, van Nuland, N.A, Bonvin, A.M. | 登録日 | 2002-09-17 | 公開日 | 2003-03-11 | 最終更新日 | 2024-07-10 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Study of Mersacidin and Lipid II Interaction in Dodecylphosphocholine Micelles. Conformational Changes are a Key to Antimicrobial Activity J.Biol.Chem., 278, 2003
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6CPI
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![BU of 6cpi by Molmil](/molmil-images/mine/6cpi) | Solution structure of SH3 domain from Shank1 | 分子名称: | SH3 and multiple ankyrin repeat domains protein 1 | 著者 | Ishida, H, Vogel, H.J. | 登録日 | 2018-03-13 | 公開日 | 2018-08-15 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels. FEBS Lett., 592, 2018
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