PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

---

4F0A	Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-8, PALMITOLEIC ACID, ... 著者 Janda, C.Y, Waghray, D, Levin, A.M, Thomas, C, Garcia, K.C. 登録日 2012-05-03 公開日 2012-06-13 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structural basis of Wnt recognition by Frizzled. Science, 337, 2012
4FBJ	Structure of the Cif:Nedd8 complex - Photorhabdus luminescens Cycle Inhibiting Factor in complex with human Nedd8 分子名称: CHLORIDE ION, Hypothetical protein, NEDD8 著者 Crow, A, Banfield, M.J. 登録日 2012-05-23 公開日 2012-06-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The molecular basis of Nedd8 deamidation by the bacterial effector protein Cif Proc.Natl.Acad.Sci.USA, 2012
4FKO	Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor 分子名称: 2-chloro-N~4~-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-N~1~,N~1~-dimethylbenzene-1,4-diamine, ACETATE ION, Cyclin-dependent kinase 2 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor To be Published
4FKJ	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor 分子名称: ACETATE ION, Cyclin-dependent kinase 2, N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]acetamide 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Crystal structure of the cdk2 in complex with aminopyrazole inhibitor To be Published
4FKW	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: 2-methylpropyl (3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxylate, Cyclin-dependent kinase 2, GLYCEROL 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2013-05-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4FL5	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Schumacher, B, Ottmann, C. 登録日 2012-06-14 公開日 2013-12-11 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. FASEB J., 29, 2015
4FKR	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: (8Z)-8-{[(2,2-dioxido-1,3-dihydro-2-benzothiophen-5-yl)amino]methylidene}-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one, Cyclin-dependent kinase 2, GLYCEROL 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4FKL	Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor 分子名称: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE, Cyclin-dependent kinase 2 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor To be Published
7O7K	Crystal structure of the human DYRK1A kinase domain bound to abemaciclib 分子名称: 1,2-ETHANEDIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... 著者 Kaltheuner, I.H, Anand, K, Geyer, M. 登録日 2021-04-13 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. Nat Commun, 12, 2021
7O7I	Crystal structure of the human HIPK3 kinase domain 分子名称: 1,2-ETHANEDIOL, Homeodomain-interacting protein kinase 3 著者 Kaltheuner, I.H, Anand, K, Geyer, M. 登録日 2021-04-13 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. Nat Commun, 12, 2021
7O7J	Crystal structure of the human HIPK3 kinase domain bound to abemaciclib 分子名称: Homeodomain-interacting protein kinase 3, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine 著者 Kaltheuner, I.H, Anand, K, Geyer, M. 登録日 2021-04-13 公開日 2021-11-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. Nat Commun, 12, 2021
7NUE	Crystal structure of mouse PRMT6 in complex with inhibitor EML736 分子名称: Protein arginine N-methyltransferase 6, methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate 著者 Bonnefond, L, Cavarelli, J. 登録日 2021-03-11 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J.Med.Chem., 65, 2022
7NUD	Crystal structure of mouse PRMT6 in complex with inhibitor EML734 分子名称: Protein arginine N-methyltransferase 6, methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate 著者 Bonnefond, L, Cavarelli, J. 登録日 2021-03-11 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J.Med.Chem., 65, 2022
7D9V	CRTC1 pSer245 peptide in complex with 14-3-3 zeta 分子名称: 14-3-3 protein zeta/delta, CRTC1 pSer245 peptide, GLYCEROL 著者 Chen, H, Zhang, H, Xiang, S. 登録日 2020-10-14 公開日 2021-02-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7D8P	CRTC1 pSer151 peptide in complex with 14-3-3 zeta 分子名称: 14-3-3 protein zeta/delta, CRTC1 pSer151 peptide, GLYCEROL 著者 Chen, H, Zhang, H, Xiang, S. 登録日 2020-10-08 公開日 2021-02-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7D8H	CRTC1 pSer64 peptide in complex with 14-3-3 zeta 分子名称: 14-3-3 protein zeta/delta, CRTC1 pSer64 peptide 著者 Chen, H, Zhang, H, Xiang, S. 登録日 2020-10-08 公開日 2021-02-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
3P2P	ENHANCED ACTIVITY AND ALTERED SPECIFICITY OF PHOSPHOLIPASE A2 BY DELETION OF A SURFACE LOOP 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Dijkstra, B.W, Thunnissen, M.M.G.M, Kalk, K.H, Drenth, J. 登録日 1989-11-29 公開日 1990-01-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop. Science, 244, 1989
2V5W	Crystal structure of HDAC8-substrate complex 分子名称: GLYCYL-GLYCYL-GLYCINE, HISTONE DEACETYLASE 8, PEPTIDIC SUBSTRATE, ... 著者 Di Marco, S, Vannini, A, Volpari, C. 登録日 2007-07-10 公開日 2007-09-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex Embo Rep., 8, 2007
4FKV	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: (3Z)-N-[2-(1H-imidazol-4-yl)ethyl]-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxamide, Cyclin-dependent kinase 2, GLYCEROL 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2013-05-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
7OBH	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-22 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
4GUL	Study on structure and function relationships in human ferric Pirin 分子名称: FE (III) ION, Pirin 著者 Liu, F, Rehmani, I, Fu, R, Esaka, S, Chen, L, Serrano, V, Liu, A. 登録日 2012-08-29 公開日 2013-05-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Pirin is an iron-dependent redox regulator of NF-kappa B. Proc.Natl.Acad.Sci.USA, 110, 2013
7OBX	Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-23 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBG	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-22 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBY	Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide and stabilizer Fusicoccin-A 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-24 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBS	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-23 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023

<459460461462463464465466467468469470471472473474>