PDB: 97138 件ウェブページステータス検索Chemie searchBIRD

---

4ALG	N-Terminal Bromodomain of Human BRD2 With IBET-151 分子名称: 7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE, ACETATE ION, BROMODOMAIN-CONTAINING PROTEIN 2, ... 著者 Chung, C, Lamotte, Y, Donche, F, Bouillot, A, Mirguet, O. 登録日 2012-03-03 公開日 2012-07-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A). Bioorg.Med.Chem.Lett., 22, 2012
4ACO	Structure of the budding yeast Ndc10 N-terminal domain 分子名称: CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT A 著者 Perriches, T, Singleton, M.R. 登録日 2011-12-16 公開日 2012-01-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 The Structure of the Yeast Kinetochore Ndc10 DNA-Binding Domain Reveals an Unexpected Evolutionary Relationship to Tyrosine Recombinases. J.Biol.Chem., 287, 2012
4C94	Crystal Structure of the Strawberry Pathogenesis-Related 10 (PR-10) Fra a 3 protein in complex with Catechin 分子名称: (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol, FRA A 3 ALLERGEN 著者 Casanal, A, Zander, U, Valpuesta, V, Marquez, J.A. 登録日 2013-10-02 公開日 2013-10-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The Strawberry Pathogenesis-Related 10 (Pr-10) Fra a Proteins Control Flavonoid Biosynthesis by Binding to Metabolic Intermediates. J.Biol.Chem., 288, 2013
3UPE	Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor 分子名称: 1-[(7-carbamimidoylnaphthalen-2-yl)methyl]-6-({1-[(1Z)-ethanimidoyl]piperidin-4-yl}oxy)-2-(propan-2-yl)-1H-indole-4-carboxylic acid, CALCIUM ION, Cationic trypsin, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-11-18 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3UWI	Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Cationic trypsin, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-12-02 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3UQO	Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor 分子名称: 3-(3-carbamimidoylphenyl)-N-(2'-sulfamoylbiphenyl-4-yl)-1,2-oxazole-4-carboxamide, CALCIUM ION, Cationic trypsin 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-11-21 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
2WEY	Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals 分子名称: 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE, CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE, ... 著者 Andersen, O.A, Schonfeld, D.L, Toogood-Johnson, I, Felicetti, B, Albrecht, C, Fryatt, T, Whittaker, M, Hallett, D, Barker, J. 登録日 2009-04-02 公開日 2009-07-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Cross-Linking of Protein Crystals as an Aid in the Generation of Binary Protein-Ligand Crystal Complexes, Exemplified by the Human Pde10A-Papaverine Structure. Acta Crystallogr.,Sect.D, 65, 2009
4CLF	Crystal structure of human soluble Adenylyl Cyclase (Apo form) 分子名称: ACETATE ION, ADENYLATE CYCLASE TYPE 10, GLYCEROL 著者 Kleinboelting, S, Moniot, S, Weyand, M, Steegborn, C. 登録日 2014-01-14 公開日 2014-03-05 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
3V12	Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor 分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-12-09 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
2VU4	Structure of PsbP protein from Spinacia oleracea at 1.98 A resolution 分子名称: OXYGEN-EVOLVING ENHANCER PROTEIN 2, ZINC ION 著者 Lapkouski, M, Ristvejova, R, Arellano, J.B, Revuelta, J.L, Kuta Smatanova, I, Ettrich, R. 登録日 2008-05-21 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Raman Spectroscopy Adds Complementary Detail to the High-Resolution X-Ray Crystal Structure of Photosynthetic Psbp from Spinacia Oleracea. Plos One, 7, 2012
4AUV	Crystal Structure of the BRMS1 N-terminal region 分子名称: ACETIC ACID, BREAST CANCER METASTASIS SUPPRESSOR 1, CHLORIDE ION, ... 著者 Spinola-Amilibia, M, Rivera, J, Ortiz-Lombardia, M, Romero, A, Neira, J.L, Bravo, J. 登録日 2012-05-22 公開日 2013-03-20 最終更新日 2019-11-06 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Brms151-98 and Brms151-84 are Crystal Oligomeric Coiled Coils with Different Oligomerization States, which Behave as Disordered Protein Fragments in Solution. J.Mol.Biol., 425, 2013
3UNQ	Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor 分子名称: 1,2-ETHANEDIOL, BENZAMIDINE, CALCIUM ION, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-11-16 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3UUZ	Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor 分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-11-29 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3UNS	Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor 分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-11-16 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3UOP	Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor 分子名称: CALCIUM ION, CHLORIDE ION, Cationic trypsin, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-11-17 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3VCH	Thaumatin by Classical Hanging Drop Vapour Diffusion after 9.05 MGy X-Ray dose at ESRF ID29 beamline (Best Case) 分子名称: GLYCEROL, Thaumatin I 著者 Belmonte, L, Pechkova, E, Scudieri, D, Nicolini, C. 登録日 2012-01-04 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Langmuir-blodgett nanotemplate and radiation resistance in protein crystals: state of the art. Crit Rev Eukaryot Gene Expr, 22, 2012
1SZD	Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, CHLORIDE ION, GLYCEROL, ... 著者 Zhao, K, Harshaw, R, Chai, X, Marmorstein, R. 登録日 2004-04-05 公開日 2004-06-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. Proc.Natl.Acad.Sci.Usa, 101, 2004
1EUZ	GLUTAMATE DEHYDROGENASE FROM THERMOCOCCUS PROFUNDUS IN THE UNLIGATED STATE 分子名称: GLUTAMATE DEHYDROGENASE, SULFATE ION 著者 Nakasako, M. 登録日 2000-04-19 公開日 2001-04-25 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Large-scale domain movements and hydration structure changes in the active-site cleft of unligated glutamate dehydrogenase from Thermococcus profundus studied by cryogenic X-ray crystal structure analysis and small-angle X-ray scattering. Biochemistry, 40, 2001
1E57	PHYSALIS MOTTLE VIRUS: EMPTY CAPSID 分子名称: PHYSALIS MOTTLE VIRUS 著者 Krishna, S.S, Sastri, M, Savithri, H.S, Murthy, M.R.N. 登録日 2000-07-18 公開日 2001-04-26 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural Studies on the Empty Capsids of Physalis Mottle Virus J.Mol.Biol., 307, 2001
2QN4	Structure and function study of rice bifunctional alpha-amylase/subtilisin inhibitor from Oryza sativa 分子名称: Alpha-amylase/subtilisin inhibitor 著者 Peng, W.Y, Lin, Y.H, Huang, Y.C, Guan, H.H, Hsieh, Y.C, Chen, C.J. 登録日 2007-07-18 公開日 2008-07-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure and Function Study of Rice Bifunctional Alpha-Amylase/Subtilisin Inhibitor from Oryza Sativa To be Published
3UQV	Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor 分子名称: 3-(3-carbamimidoylphenyl)-N-(2'-sulfamoylbiphenyl-4-yl)-1,2-oxazole-4-carboxamide, CALCIUM ION, Cationic trypsin, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-11-21 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
2WAP	3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with the drug-like urea inhibitor PF-3845 分子名称: 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid, CHLORIDE ION, FATTY-ACID AMIDE HYDROLASE 1, ... 著者 Mileni, M, Kamtekar, S, Stevens, R.C. 登録日 2009-02-11 公開日 2009-05-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery and Characterization of a Highly Selective Faah Inhibitor that Reduces Inflammatory Pain. Chem.Biol., 16, 2009
3UY9	Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor 分子名称: BENZAMIDINE, CALCIUM ION, CHLORIDE ION, ... 著者 Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. 登録日 2011-12-06 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
3W2S	EGFR kinase domain with compound4 分子名称: 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5H-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea, Epidermal growth factor receptor, SULFATE ION 著者 Sogabe, S, Kawakita, Y, Igaki, S. 登録日 2012-12-03 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors. Acs Med.Chem.Lett., 4, 2013
3W2O	EGFR Kinase domain T790M/L858R Mutant with TAK-285 分子名称: Epidermal growth factor receptor, N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide 著者 Sogabe, S, Kawakita, Y, Igaki, S. 登録日 2012-12-03 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors. Acs Med.Chem.Lett., 4, 2013

<446447448449450451452453454455456457458459460461>