1H2A
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7E3H
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![BU of 7e3h by Molmil](/molmil-images/mine/7e3h) | Crystal structure of human acetylcholinesterase in complex with donepezil | 分子名称: | 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase | 著者 | Dileep, K.V, Ihara, K, Mishima-Tsumagari, C, Kukimoto-Niino, M, Yonemochi, M, Hanada, K, Shirouzu, M, Zhang, K.Y.J. | 登録日 | 2021-02-08 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery Int.J.Biol.Macromol., 210, 2022
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1GRB
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1BMR
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![BU of 1bmr by Molmil](/molmil-images/mine/1bmr) | ALPHA-LIKE TOXIN LQH III FROM SCORPION LEIURUS QUINQUESTRIATUS HEBRAEUS, NMR, 25 STRUCTURES | 分子名称: | LQH III ALPHA-LIKE TOXIN | 著者 | Krimm, I, Gilles, N, Sautiere, P, Stankiewicz, M, Pelhate, M, Gordon, D, Lancelin, J.-M. | 登録日 | 1998-07-24 | 公開日 | 1999-02-16 | 最終更新日 | 2022-02-16 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus. J.Mol.Biol., 285, 1999
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2L7J
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6V8Q
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![BU of 6v8q by Molmil](/molmil-images/mine/6v8q) | Structure of an inner membrane protein required for PhoPQ regulated increases in outer membrane cardiolipin | 分子名称: | (9Z,21R,24R,30R,33R,44Z)-24,27,30-trihydroxy-18,24,30,36-tetraoxo-19,23,25,29,31,35-hexaoxa-24lambda~5~,30lambda~5~-dip hosphatripentaconta-9,44-diene-21,33-diyl (9Z,9'Z)di-octadec-9-enoate, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Fan, J, Miller, S. | 登録日 | 2019-12-11 | 公開日 | 2020-03-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.699585 Å) | 主引用文献 | Structure of an Inner Membrane Protein Required for PhoPQ-Regulated Increases in Outer Membrane Cardiolipin. Mbio, 11, 2020
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7E73
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7E75
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1I7K
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6USX
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![BU of 6usx by Molmil](/molmil-images/mine/6usx) | Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer | 分子名称: | 1-{4-[2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Vigers, G.P, Smith, D.J. | 登録日 | 2019-10-28 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer. J.Med.Chem., 63, 2020
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1HRA
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![BU of 1hra by Molmil](/molmil-images/mine/1hra) | THE SOLUTION STRUCTURE OF THE HUMAN RETINOIC ACID RECEPTOR-BETA DNA-BINDING DOMAIN | 分子名称: | RETINOIC ACID RECEPTOR, ZINC ION | 著者 | Knegtel, R.M.A, Katahira, M, Schilthuis, J.G, Bonvin, A.M.J.J, Boelens, R, Eib, D, Van Der Saag, P.T, Kaptein, R. | 登録日 | 1993-07-25 | 公開日 | 1994-01-31 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of the human retinoic acid receptor-beta DNA-binding domain. J.Biomol.NMR, 3, 1993
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2LM2
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![BU of 2lm2 by Molmil](/molmil-images/mine/2lm2) | NMR structures of the transmembrane domains of the AChR b2 subunit | 分子名称: | Neuronal acetylcholine receptor subunit beta-2 | 著者 | Bondarenko, V, Mowrey, D, Tillman, T, Cui, T, Liu, L.T, Xu, Y, Tang, P. | 登録日 | 2011-11-18 | 公開日 | 2012-03-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structures of the transmembrane domains of the a4b2 nAChR. Biochim.Biophys.Acta, 1818, 2012
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2LC6
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6UZY
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![BU of 6uzy by Molmil](/molmil-images/mine/6uzy) | Cryo-EM structure of Xenopus tropicalis pannexin 1 | 分子名称: | HEXADECANE, Pannexin, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | 著者 | Deng, Z, He, Z, Yuan, P. | 登録日 | 2019-11-15 | 公開日 | 2020-04-01 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Cryo-EM structures of the ATP release channel pannexin 1. Nat.Struct.Mol.Biol., 27, 2020
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6UT0
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![BU of 6ut0 by Molmil](/molmil-images/mine/6ut0) | Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Vigers, G.P, Smith, D.J. | 登録日 | 2019-10-29 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer. J.Med.Chem., 63, 2020
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7ENQ
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![BU of 7enq by Molmil](/molmil-images/mine/7enq) | Crystal structure of human NAMPT in complex with compound NAT | 分子名称: | 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | 著者 | Wang, G, Wu, C, Liu, M, Yao, H, Li, C, Wang, L, Tang, Y. | 登録日 | 2021-04-19 | 公開日 | 2022-05-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.204966 Å) | 主引用文献 | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res., 32, 2022
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1CKT
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![BU of 1ckt by Molmil](/molmil-images/mine/1ckt) | CRYSTAL STRUCTURE OF HMG1 DOMAIN A BOUND TO A CISPLATIN-MODIFIED DNA DUPLEX | 分子名称: | Cisplatin, DNA (5'-D(*CP*CP*(5IU)P*CP*TP*CP*TP*GP*GP*AP*CP*CP*TP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*GP*TP*CP*CP*AP*GP*AP*GP*AP*GP*G)-3'), ... | 著者 | Ohndorf, U.-M, Rould, M.A, Pabo, C.O, Lippard, S.J. | 登録日 | 1999-04-23 | 公開日 | 1999-06-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins. Nature, 399, 1999
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6VAM
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2LUC
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1H1K
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![BU of 1h1k by Molmil](/molmil-images/mine/1h1k) | THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA | 分子名称: | RNA | 著者 | Diprose, J.M, Grimes, J.M, Sutton, G.C, Burroughs, J.N, Meyer, A, Maan, S, Mertens, P.P.C, Stuart, D.I. | 登録日 | 2002-07-17 | 公開日 | 2002-09-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (10 Å) | 主引用文献 | The Core of Bluetongue Virus Binds Double-Stranded RNA J.Virol., 76, 2002
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1BSI
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![BU of 1bsi by Molmil](/molmil-images/mine/1bsi) | HUMAN PANCREATIC ALPHA-AMYLASE FROM PICHIA PASTORIS, GLYCOSYLATED PROTEIN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-AMYLASE, CALCIUM ION, ... | 著者 | Rydberg, E.H, Sidhu, G, Vo, H.C, Hewitt, J, Cote, H.C.F, Wang, Y, Numao, S, Macgillivray, R.T.A, Overall, C.M, Brayer, G.D, Withers, S.G. | 登録日 | 1998-08-28 | 公開日 | 1999-05-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris. Protein Sci., 8, 1999
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7EOK
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7EOO
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7EOP
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7EOL
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