8D5E
 
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2HYE
 | | Crystal Structure of the DDB1-Cul4A-Rbx1-SV5V Complex | | 分子名称: | Cullin-4A, DNA damage-binding protein 1, Nonstructural protein V, ... | | 著者 | Angers, S, Li, T, Yi, X, MacCoss, M.J, Moon, R.T, Zheng, N. | | 登録日 | 2006-08-05 | | 公開日 | 2006-10-03 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
Nature, 443, 2006
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8D5F
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3NUX
 | | CDK6 (monomeric) in complex with inhibitor | | 分子名称: | 4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine, Cell division protein kinase 6 | | 著者 | Chopra, R. | | 登録日 | 2010-07-07 | | 公開日 | 2010-12-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.
J.Med.Chem., 53, 2010
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3NTP
 | | Human Pin1 complexed with reduced amide inhibitor | | 分子名称: | (2R)-2-(acetylamino)-3-[(2S)-2-{[2-(1H-indol-3-yl)ethyl]carbamoyl}pyrrolidin-1-yl]propyl dihydrogen phosphate, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | 著者 | Zhang, Y. | | 登録日 | 2010-07-05 | | 公開日 | 2012-01-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.762 Å) | | 主引用文献 | A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state.
Biochemistry, 50, 2011
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3K4X
 | | Eukaryotic Sliding Clamp PCNA Bound to DNA | | 分子名称: | DNA (5'-D(*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), Proliferating cell nuclear antigen | | 著者 | McNally, R, Kuriyan, J. | | 登録日 | 2009-10-06 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Analysis of the role of PCNA-DNA contacts during clamp loading.
Bmc Struct.Biol., 10, 2010
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3MHR
 | | 14-3-3 sigma in complex with YAP pS127-peptide | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Schumacher, B, Skwarczynska, M, Rose, R, Ottmann, C. | | 登録日 | 2010-04-08 | | 公開日 | 2010-09-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Structure of a 14-3-3[sigma]-YAP phosphopeptide complex at 1.15 A resolution
Acta Crystallogr.,Sect.F, 66, 2010
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3ODK
 | | Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3-pyridin-2-yl-1H-pyrazole-5-carboxylic acid, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | 著者 | Potter, A, Oldfield, V, Nunns, C, Fromont, C, Ray, S, Northfield, C.J, Bryant, C.J, Scrace, S.F, Robinson, D, Matossova, N, Baker, L, Dokurno, P, Surgenor, A.E, Davis, B.E, Richardson, C.M, Murray, J.B, Moore, J.D. | | 登録日 | 2010-08-11 | | 公開日 | 2010-10-27 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.
Bioorg.Med.Chem.Lett., 20, 2010
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2KEQ
 | | Solution structure of DnaE intein from Nostoc punctiforme | | 分子名称: | DNA polymerase III alpha subunit, Nucleic acid binding OB-fold tRNA/helicase-type | | 著者 | Oeemig, J.S, Aranko, A.S, Djupsj, J.B, Iwai, H. | | 登録日 | 2009-02-02 | | 公開日 | 2009-05-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of DnaE intein from Nostoc punctiforme: structural basis for the design of a new split intein suitable for site-specific chemical modification.
Febs Lett., 583, 2009
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2JUP
 | | FBP28WW2 domain in complex with the PPLIPPPP peptide | | 分子名称: | Formin-1, Transcription elongation regulator 1 | | 著者 | Ramirez-Espain, X, Ruiz, L, Martin-Malpartida, P, Oschkinat, H, Macias, M.J. | | 登録日 | 2007-09-01 | | 公開日 | 2007-11-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Characterization of a New Binding Motif and a Novel Binding Mode in Group 2 WW Domains
J.Mol.Biol., 373, 2007
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2K9H
 | | The hantavirus glycoprotein G1 tail contains a dual CCHC-type classical zinc fingers | | 分子名称: | Glycoprotein, ZINC ION | | 著者 | Estrada, D.F, Boudreaux, D.M, Zhong, D, St Jeor, S.C, De Guzman, R.N. | | 登録日 | 2008-10-13 | | 公開日 | 2009-01-27 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Hantavirus Glycoprotein G1 Tail Contains Dual CCHC-type Classical Zinc Fingers.
J.Biol.Chem., 284, 2009
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2M13
 | | The ZZ domain of cytoplasmic polyadenylation element binding protein 1 (CPEB1) | | 分子名称: | Cytoplasmic polyadenylation element-binding protein 1, ZINC ION | | 著者 | Lee, B.M, Merkel, D.J, Wells, S.B, Hilburn, B.C, Elazzouzi, F, Perez-Alvarado, G.C. | | 登録日 | 2012-11-14 | | 公開日 | 2013-04-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The C-Terminal Region of Cytoplasmic Polyadenylation Element Binding Protein Is a ZZ Domain with Potential for Protein-Protein Interactions.
J.Mol.Biol., 425, 2013
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4HSA
 | | Structure of interleukin 17a in complex with il17ra receptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | | 著者 | Liu, S. | | 登録日 | 2012-10-29 | | 公開日 | 2013-05-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Crystal structures of interleukin 17A and its complex with IL-17 receptor A.
Nat Commun, 4, 2013
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2LIF
 | | Solution Structure of KKGF | | 分子名称: | Core protein p21 | | 著者 | Montserret, R, Penin, F. | | 登録日 | 2011-08-29 | | 公開日 | 2012-07-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural analysis of hepatitis C virus core-e1 signal Peptide and requirements for cleavage of the genotype 3a signal sequence by signal Peptide peptidase.
J.Virol., 86, 2012
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5XF8
 | | Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state | | 分子名称: | Cell division cycle protein CDT1, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... | | 著者 | Zhai, Y, Cheng, E, Wu, H, Li, N, Yung, P.Y, Gao, N, Tye, B.K. | | 登録日 | 2017-04-09 | | 公開日 | 2017-05-03 | | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | | 主引用文献 | Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer
Nat. Struct. Mol. Biol., 24, 2017
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1SVB
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5FCW
 | | HDAC8 Complexed with a Hydroxamic Acid | | 分子名称: | 4-naphthalen-1-yl-~{N}-oxidanyl-benzamide, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | 著者 | Cole, K.E, Perry, K. | | 登録日 | 2015-12-15 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | | 主引用文献 | Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket.
J.Struct.Biol., 195, 2016
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5FH2
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5FRF
 | | Solution structure of reduced and zinc-bound RsrA | | 分子名称: | ANTI-SIGMA FACTOR RSRA, ZINC ION | | 著者 | Zdanowski, K, Pecqueur, L, Werner, J, Potts, J.R, Kleanthous, C. | | 登録日 | 2015-12-17 | | 公開日 | 2016-08-03 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Anti-Sigma Factor Rsra Responds to Oxidative Stress by Reburying its Hydrophobic Core.
Nat.Commun., 7, 2016
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5XV8
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5FH3
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4I77
 | | Lebrikizumab Fab bound to IL-13 | | 分子名称: | Interleukin-13, Lebrikizumab heavy chain, Lebrikizumab light chain | | 著者 | Eigenbrot, C, Ultsch, M. | | 登録日 | 2012-11-30 | | 公開日 | 2013-02-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab.
J.Mol.Biol., 425, 2013
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5G1A
 | | Bordetella Alcaligenes HDAH bound to PFSAHA | | 分子名称: | 2,2,3,3,4,4,5,5,6,6,7,7-dodecakis(fluoranyl)-~{N}-oxidanyl-~{N}'-phenyl-octanediamide, DI(HYDROXYETHYL)ETHER, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ... | | 著者 | Kraemer, A, Meyer-Almes, F.J, Yildiz, O. | | 登録日 | 2016-03-24 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | The thermodynamic signature of ligand binding to histone deacetylase-like amidohydrolases is most sensitive to the flexibility in the L2-loop lining the active site pocket.
Biochim. Biophys. Acta, 1861, 2017
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2R6M
 | | Crystal structure of rat CK2-beta subunit | | 分子名称: | Casein kinase II subunit beta, ZINC ION | | 著者 | Shen, Y. | | 登録日 | 2007-09-06 | | 公開日 | 2008-09-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2
CHIN.SCI.BULL., 54, 2009
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5X6U
 | | Crystal structure of human heteropentameric complex | | 分子名称: | Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... | | 著者 | Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. | | 登録日 | 2017-02-23 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun, 8, 2017
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