3ODK
Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution
Summary for 3ODK
Entry DOI | 10.2210/pdb3odk/pdb |
Related | 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE |
Descriptor | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3-pyridin-2-yl-1H-pyrazole-5-carboxylic acid, ... (4 entities in total) |
Functional Keywords | sbdd, ppiase, isomerase, rotamase, small molecule, proline directed kinase, cell cycle, oncogenic transformation, nucleus, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q13526 |
Total number of polymer chains | 1 |
Total formula weight | 19068.13 |
Authors | Potter, A.,Oldfield, V.,Nunns, C.,Fromont, C.,Ray, S.,Northfield, C.J.,Bryant, C.J.,Scrace, S.F.,Robinson, D.,Matossova, N.,Baker, L.,Dokurno, P.,Surgenor, A.E.,Davis, B.E.,Richardson, C.M.,Murray, J.B.,Moore, J.D. (deposition date: 2010-08-11, release date: 2010-10-27, Last modification date: 2024-02-21) |
Primary citation | Potter, A.,Oldfield, V.,Nunns, C.,Fromont, C.,Ray, S.,Northfield, C.J.,Bryant, C.J.,Scrace, S.F.,Robinson, D.,Matossova, N.,Baker, L.,Dokurno, P.,Surgenor, A.E.,Davis, B.,Richardson, C.M.,Murray, J.B.,Moore, J.D. Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution. Bioorg.Med.Chem.Lett., 20:6483-6488, 2010 Cited by PubMed: 20932746DOI: 10.1016/j.bmcl.2010.09.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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