PDB: 71589 件ウェブページステータス検索Chemie searchBIRD

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7NCF	Crystal structure of HIPK2 in complex with MU135 (compound 21e) 分子名称: 3-(4-Tert-butylphenyl)-5-(1H-pyrazol-4-yl)furo[3,2-b]pyridine, Homeodomain-interacting protein kinase 2 著者 Chaikuad, A, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2021-01-28 公開日 2021-03-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Eur.J.Med.Chem., 215, 2021
3LXP	Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 分子名称: 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Non-receptor tyrosine-protein kinase TYK2 著者 Chrencik, J.E, Benson, T.E. 登録日 2010-02-25 公開日 2010-06-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. J.Mol.Biol., 400, 2010
5HOR	Crystal structure of c-Met-M1250T in complex with SAR125844. 分子名称: 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea, Hepatocyte growth factor receptor 著者 Vallee, F, Houtmann, J, Marquette, J.-P. 登録日 2016-01-19 公開日 2016-11-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
4HR3	Structure of a putative acyl-CoA dehydrogenase from Mycobacterium abscessus 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Putative acyl-CoA dehydrogenase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-10-26 公開日 2012-11-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3LXK	Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 分子名称: 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile, Tyrosine-protein kinase JAK3 著者 Chrencik, J.E, Patny, A, Leung, I.K, Korniski, B, Emmons, T.L, Benson, T.E. 登録日 2010-02-25 公開日 2010-06-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. J.Mol.Biol., 400, 2010
5HWN	Crystal structure of keto-deoxy-D-galactarate dehydratase complexed with pyruvate 分子名称: FORMIC ACID, GLYCEROL, PYRUVIC ACID, ... 著者 Taberman, H, Parkkinen, T, Hakulinen, N, Rouvinen, J. 登録日 2016-01-29 公開日 2016-03-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.499 Å) 主引用文献 Structure and function of a decarboxylating Agrobacterium tumefaciens keto-deoxy-d-galactarate dehydratase. Biochemistry, 53, 2014
7NEQ	Structure of tariquidar-bound ABCG2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... 著者 Kowal, J, Locher, K. 登録日 2021-02-04 公開日 2021-04-21 最終更新日 2021-05-12 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
3LY2	Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor 分子名称: 8-(cyclopentyloxy)-4-[(3,5-dichloropyridin-4-yl)amino]-7-methoxy-2H-chromen-2-one, MAGNESIUM ION, SULFATE ION, ... 著者 Shiau, A.K, Coyle, A.R, Hsien, J.H, Staszewski, L.M. 登録日 2010-02-26 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Water-soluble PDE4 inhibitors for the treatment of dry eye. Bioorg.Med.Chem.Lett., 20, 2010
5HLW	Crystal structure of c-Met mutant Y1230H in complex with compound 14 分子名称: 1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-(6-{[6-(thiophen-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)urea, CHLORIDE ION, Hepatocyte growth factor receptor 著者 Vallee, F, Pouzieux, S, Marquette, J.P, Houtmann, J. 登録日 2016-01-15 公開日 2016-11-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
3LXL	Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 分子名称: 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Tyrosine-protein kinase JAK3 著者 Chrencik, J.E, Benson, T.E. 登録日 2010-02-25 公開日 2010-06-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. J.Mol.Biol., 400, 2010
6DTD	High-resolution crystal structure of Cas13b from Prevotella buccae 分子名称: CHLORIDE ION, CITRIC ACID, RNA (37-MER), ... 著者 Slaymaker, I.M.S, Zhang, F.Z. 登録日 2018-06-15 公開日 2019-02-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage. Cell Rep, 26, 2019
5HOA	Crystal structure of c-Met L1195V in complex with SAR125844 分子名称: 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea, Hepatocyte growth factor receptor 著者 Vallee, F, Marquette, J.-P. 登録日 2016-01-19 公開日 2016-11-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
7NHU	Crystal structure of desB30 insulin produced by cell free protein synthesis 分子名称: Insulin 著者 Johansson, E. 登録日 2021-02-11 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein. Protein Expr.Purif., 186, 2021
7Z6E	Structure of the C1-PH-CNH regulatory module of MRCK1 分子名称: Serine/threonine-protein kinase mrck-1, ZINC ION 著者 Truebestein, L, Leonard, T.A. 登録日 2022-03-11 公開日 2023-02-22 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase. Structure, 31, 2023
1NYN	Solution NMR Structure of Protein YHR087W from Saccharomyces cerevisiae. Northeast Structural Genomics Consortium Target YTYST425. 分子名称: Hypothetical 12.0 kDa protein in NAM8-GAR1 intergenic region 著者 Cort, J.R, Yee, A.A, Arrowsmith, C.H, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) 登録日 2003-02-13 公開日 2003-04-08 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism. J.Biol.Chem., 280, 2005
2GDE	Thrombin in complex with inhibitor 分子名称: (R)-3-((2S,3R)-1-((2S,3AR,5S,6S,7AS)-2-(2-(1-CARBAMIMIDOYL-2,5-DIHYDRO-1H-PYRROL-3-YL)ETHYLCARBAMOYL)-5,6-DIHYDROXYOCTAHYDRO-1H-INDOL-1-YL)-3-CHLORO-4-METHYL-1-OXOPENTAN-2-YLAMINO)-2-METHOXY-3-OXOPROPYL HYDROGEN SULFATE, Hirudin, SODIUM ION, ... 著者 Xue, Y. 登録日 2006-03-16 公開日 2007-03-20 最終更新日 2013-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Total synthesis and structural confirmation of chlorodysinosin A. J.Am.Chem.Soc., 128, 2006
7Z7C	Broadly neutralizing DARPin bnD.8 in complex with the HIV-1 envelope variable loop 3 peptide V3 (BF520) 分子名称: 1,2-ETHANEDIOL, Broadly neutralizing DARPin bnD.8, Envelope glycoprotein gp160, ... 著者 Mittl, P.R, Gloegl, M. 登録日 2022-03-15 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization. Nat.Struct.Mol.Biol., 30, 2023
5HVW	Monomeric IgG4 Fc 分子名称: GLYCEROL, Ig gamma-4 chain C region, ZINC ION, ... 著者 Oganesyan, V.Y, Shan, L, Dall'Acqua, W.F. 登録日 2016-01-28 公開日 2016-08-17 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Generation and Characterization of an IgG4 Monomeric Fc Platform. Plos One, 11, 2016
4UMO	Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin 分子名称: CALCIUM ION, CALMODULIN, POTASSIUM ION, ... 著者 Sachyani, D, Hirsch, J.A. 登録日 2014-05-20 公開日 2014-11-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Basis of a Kv7.1 Potassium Channel Gating Module: Studies of the Intracellular C-Terminal Domain in Complex with Calmodulin Structure, 22, 2014
3MBQ	Crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase from Brucella melitensis, orthorhombic crystal form 分子名称: 1,2-ETHANEDIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, GLYCEROL, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2010-03-25 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase from Brucella melitensis, orthorhombic crystal form To be Published
3MCY	Crystal structure of FimH lectin domain bound to biphenyl mannoside meta-methyl ester. 分子名称: CALCIUM ION, CHLORIDE ION, FimH, ... 著者 Ford, B.A, Hultgren, S.J. 登録日 2010-03-29 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-based drug design and optimization of mannoside bacterial FimH antagonists. J.Med.Chem., 53, 2010
7ZBZ	CAND1 delhairpin-SCF-SKP2 CAND1 partly engaged SCF partly rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-24 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
7MYR	BACE-1 in complex with compound #18 分子名称: (4aR,7aR)-6-(5-fluoropyrimidin-2-yl)-7a-(1,2-thiazol-5-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-amine, Beta-secretase 1, GLYCEROL, ... 著者 Hendle, J, Timm, D.E, Stout, S.L. 登録日 2021-05-21 公開日 2021-07-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor. J.Med.Chem., 64, 2021
7Z8R	CAND1-CUL1-RBX1 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-18 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
5I0T	Thiosulfate bound Cysteine Dioxygenase at pH 6.8 分子名称: Cysteine dioxygenase type 1, FE (III) ION, THIOSULFATE 著者 Kean, K.M, Driggers, C.M, Karplus, P.A. 登録日 2016-02-04 公開日 2016-12-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016

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