1CK7
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![BU of 1ck7 by Molmil](/molmil-images/mine/1ck7) | GELATINASE A (FULL-LENGTH) | 分子名称: | CALCIUM ION, CHLORIDE ION, PROTEIN (GELATINASE A), ... | 著者 | Morgunova, E, Tuuttila, A, Bergmann, U, Isupov, M, Lindqvist, Y, Schneider, G, Tryggvason, K. | 登録日 | 1999-04-28 | 公開日 | 1999-08-25 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed. Science, 284, 1999
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4YND
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![BU of 4ynd by Molmil](/molmil-images/mine/4ynd) | The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2 | 分子名称: | N-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[(2R)-2-hydroxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... | 著者 | Sweis, R.F, Wang, Z, Algire, M, Arrowsmith, C.H, Brown, P.J, Chiang, G.C, Guo, J, Jakob, C.G, Kennedy, S, Li, F, Soni, N.B, Vedadi, M, Pappano, W.N. | 登録日 | 2015-03-09 | 公開日 | 2015-05-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. Acs Med.Chem.Lett., 6, 2015
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5UVC
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![BU of 5uvc by Molmil](/molmil-images/mine/5uvc) | Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure | 分子名称: | Beta-adrenergic receptor kinase 1, N-benzyl-3-({[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)benzamide, SULFATE ION | 著者 | Hoffman, I.D, Lawson, J.D. | 登録日 | 2017-02-20 | 公開日 | 2017-07-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J. Med. Chem., 60, 2017
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5UVX
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![BU of 5uvx by Molmil](/molmil-images/mine/5uvx) | BRD4 Bromodomain 2 with A-1359643 | 分子名称: | Bromodomain-containing protein 4, N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]methanesulfonamide | 著者 | Park, C.H. | 登録日 | 2017-02-20 | 公開日 | 2017-06-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | BRD4 Bromodomain 2 with A-1359643 To Be Published
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3KZJ
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![BU of 3kzj by Molmil](/molmil-images/mine/3kzj) | Structure of complement Factor H variant R1203A | 分子名称: | Complement factor H, SULFATE ION | 著者 | Bhattacharjee, A, Lehtinen, M.J, Kajander, T, Goldman, A, Jokiranta, T.S. | 登録日 | 2009-12-08 | 公開日 | 2010-05-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d Mol.Immunol., 47, 2010
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5UY8
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![BU of 5uy8 by Molmil](/molmil-images/mine/5uy8) | Crystal structure of AICARFT bound to an antifolate | 分子名称: | 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, ... | 著者 | Wang, J, Wang, Y, Fales, K.R, Atwell, S, Clawson, D. | 登録日 | 2017-02-23 | 公開日 | 2018-01-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J. Med. Chem., 60, 2017
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5UZ0
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![BU of 5uz0 by Molmil](/molmil-images/mine/5uz0) | Crystal structure of AICARFT bound to an antifolate | 分子名称: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, MAGNESIUM ION, ... | 著者 | Atwell, S, Wang, Y, Fales, K.R, Clawson, D, Wang, J. | 登録日 | 2017-02-24 | 公開日 | 2018-01-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J. Med. Chem., 60, 2017
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5JMM
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1UHS
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![BU of 1uhs by Molmil](/molmil-images/mine/1uhs) | Solution structure of mouse homeodomain-only protein HOP | 分子名称: | homeodomain only protein | 著者 | Saito, K, Koshiba, S, Inoue, M, Shirouzu, M, Terada, T, Yabuki, T, Aoki, M, Matsuda, T, Seki, E, Hirota, H, Yoshida, M, Tanaka, A, Osanai, T, Arakawa, T, Carninci, P, Kawai, J, Hayashizaki, Y, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-07-10 | 公開日 | 2004-07-10 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of mouse homeodomain-only protein HOP To be Published
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5V82
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![BU of 5v82 by Molmil](/molmil-images/mine/5v82) | PIM1 kinase in complex with Cpd17 (1-(6-(4,4-difluoropiperidin-3-yl)pyridin-2-yl)-6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine) | 分子名称: | 1-{6-[(3R)-4,4-difluoropiperidin-3-yl]pyridin-2-yl}-6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine, Serine/threonine-protein kinase pim-1 | 著者 | Murray, J.M, Wallweber, H. | 登録日 | 2017-03-21 | 公開日 | 2017-05-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.888 Å) | 主引用文献 | Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J. Med. Chem., 60, 2017
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5ULA
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![BU of 5ula by Molmil](/molmil-images/mine/5ula) | |
5ULI
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![BU of 5uli by Molmil](/molmil-images/mine/5uli) | Crystal Structure of mouse DXO in complex with (3'-NADP)+ and calcium ion | 分子名称: | CALCIUM ION, Decapping and exoribonuclease protein, [[(2R,3S,4R,5R)-5-(3-aminocarbonyl-4H-pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate | 著者 | Doamekpor, S.K, Tong, L. | 登録日 | 2017-01-24 | 公開日 | 2017-05-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Cell, 168, 2017
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5V8Q
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4YLR
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![BU of 4ylr by Molmil](/molmil-images/mine/4ylr) | Tubulin Glutamylase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Tubulin polyglutamylase TTLL7 | 著者 | Garnham, C.P, Vemu, A, Wilson-Kubalek, E.M, Yu, I, Szyk, A, Lander, G.C, Milligan, R.A, Roll-Mecak, A. | 登録日 | 2015-03-05 | 公開日 | 2015-06-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. Cell, 161, 2015
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4YM2
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1RK8
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![BU of 1rk8 by Molmil](/molmil-images/mine/1rk8) | Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex | 分子名称: | CALCIUM ION, CG8781-PA protein, Mago nashi protein, ... | 著者 | Bono, F, Ebert, J, Guettler, T, Izaurralde, E, Conti, E. | 登録日 | 2003-11-21 | 公開日 | 2004-04-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular insights into the interaction of PYM with
the Mago-Y14 core of the exon junction complex EMBO Rep., 5, 2004
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5UQV
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1RHD
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1D7K
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![BU of 1d7k by Molmil](/molmil-images/mine/1d7k) | CRYSTAL STRUCTURE OF HUMAN ORNITHINE DECARBOXYLASE AT 2.1 ANGSTROMS RESOLUTION | 分子名称: | HUMAN ORNITHINE DECARBOXYLASE | 著者 | Almrud, J.J, Oliveira, M.A, Kern, A.D, Grishin, N.V, Phillips, M.A, Hackert, M.L. | 登録日 | 1999-10-18 | 公開日 | 2000-10-25 | 最終更新日 | 2018-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. J.Mol.Biol., 295, 2000
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5UOE
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![BU of 5uoe by Molmil](/molmil-images/mine/5uoe) | |
5JI0
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![BU of 5ji0 by Molmil](/molmil-images/mine/5ji0) | PPARgamma-RXRalpha(S427F) heterodimer in complex with SRC-1, rosiglitazone, and 9-cis-retanoic acid | 分子名称: | (9cis)-retinoic acid, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... | 著者 | Bloudoff, K, Larsen, N.A. | 登録日 | 2016-04-21 | 公開日 | 2017-04-26 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | PPARgamma-RXRalpha(S427F) heterodimer in complex with SRC-1, rosiglitazone, and 9-cis-retanoic acid To Be Published
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3KR2
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3KVM
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5JI6
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![BU of 5ji6 by Molmil](/molmil-images/mine/5ji6) | Potent, Reversible MetAP2 Inhibitors via FBDD | 分子名称: | 4-(3-methylpyridin-4-yl)-6-(trifluoromethyl)-1H-indazole, MANGANESE (II) ION, Methionine aminopeptidase 2, ... | 著者 | Dougan, D.R, Lawson, J.D. | 登録日 | 2016-04-21 | 公開日 | 2016-05-25 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1. Bioorg.Med.Chem.Lett., 26, 2016
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5JIE
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