8D31
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![BU of 8d31 by Molmil](/molmil-images/mine/8d31) | [AG/TC] Self-Assembled 3D DNA Cubic Tensegrity Triangle with 24 bp Arm Length | 分子名称: | DNA (5'-D(*AP*GP*GP*CP*CP*TP*AP*CP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*AP*G)-3'), DNA (5'-D(*AP*GP*GP*CP*CP*TP*AP*GP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*AP*G)-3'), DNA (5'-D(*TP*CP*CP*TP*GP*AP*TP*GP*T)-3'), ... | 著者 | Lu, B, Vecchioni, S, Ohayon, Y.P, Seeman, N.C, Mao, C, Sha, R. | 登録日 | 2022-05-31 | 公開日 | 2023-01-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (7.45 Å) | 主引用文献 | Highly Symmetric, Self-Assembling 3D DNA Crystals with Cubic and Trigonal Lattices. Small, 19, 2023
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8Q9Q
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![BU of 8q9q by Molmil](/molmil-images/mine/8q9q) | Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC7 deacetylase binding motif | 分子名称: | HDAC7 (histone deacetylase 7) binding motif peptide: GLY-VAL-VAL-LYS-GLN-LYS-LEU-ALA-GLU-VAL-ILE-LEU-LYS-LYS-GLN, MADS box dsDNA: AACTATTTATAAGA, MADS box dsDNA: TCTTATAAATAGTT, ... | 著者 | Chinellato, M, Carli, A, Perin, S, Mazzocato, Y, Biondi, B, Di Giorgio, E, Brancolini, C, Angelini, A, Cendron, L. | 登録日 | 2023-08-20 | 公開日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol., 436, 2024
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5IZO
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![BU of 5izo by Molmil](/molmil-images/mine/5izo) | |
8Q3R
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![BU of 8q3r by Molmil](/molmil-images/mine/8q3r) | Cryo-EM structure of the DNA polymerase holoenzyme E9-A20-D4 of vaccinia virus | 分子名称: | DNA polymerase, DNA polymerase processivity factor component OPG148, Uracil-DNA glycosylase | 著者 | Burmeister, W.P, Ballandras-Colas, A, Boettcher, B, Grimm, C. | 登録日 | 2023-08-04 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure and flexibility of the DNA polymerase holoenzyme of vaccinia virus. Plos Pathog., 20, 2024
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6V2K
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![BU of 6v2k by Molmil](/molmil-images/mine/6v2k) | The nucleosome structure after H2A-H2B exchange | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A, ... | 著者 | Arimura, Y, Hirano, R, Kurumizaka, H. | 登録日 | 2019-11-24 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Histone variant H2A.B-H2B dimers are spontaneously exchanged with canonical H2A-H2B in the nucleosome. Commun Biol, 4, 2021
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7TGW
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![BU of 7tgw by Molmil](/molmil-images/mine/7tgw) | Omicron spike at 3.0 A (open form) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Ye, G, Liu, B, Li, F. | 登録日 | 2022-01-09 | 公開日 | 2022-03-09 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain. Nat Commun, 13, 2022
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8SYJ
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![BU of 8syj by Molmil](/molmil-images/mine/8syj) | Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Iodide crystal form) | 分子名称: | GLYCEROL, IODIDE ION, SULFATE ION, ... | 著者 | Eckenroth, B.E, Gardner, A.F, Doublie, S. | 登録日 | 2023-05-25 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem., 300, 2023
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7BUJ
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![BU of 7buj by Molmil](/molmil-images/mine/7buj) | mcGAS bound with pppGpG | 分子名称: | Cyclic GMP-AMP synthase, GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Wang, B, Su, X.D. | 登録日 | 2020-04-07 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Mn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP. Cell Rep, 32, 2020
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7U29
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![BU of 7u29 by Molmil](/molmil-images/mine/7u29) | Structure of SARS-CoV-2 Mpro mutant (K90R) in complex with Nirmatrelvir (PF-07321332) | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | 登録日 | 2022-02-23 | 公開日 | 2022-03-09 | 最終更新日 | 2022-06-15 | 実験手法 | X-RAY DIFFRACTION (2.088 Å) | 主引用文献 | Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants. J.Biol.Chem., 298, 2022
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7U28
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![BU of 7u28 by Molmil](/molmil-images/mine/7u28) | Structure of SARS-CoV-2 Mpro Lambda (G15S) in complex with Nirmatrelvir (PF-07321332) | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Greasley, S.E, Ferre, R.A, Plotnikova, O, Liu, W, Stewart, A.E. | 登録日 | 2022-02-23 | 公開日 | 2022-03-09 | 最終更新日 | 2022-06-15 | 実験手法 | X-RAY DIFFRACTION (1.679 Å) | 主引用文献 | Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants. J.Biol.Chem., 298, 2022
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6ZLC
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![BU of 6zlc by Molmil](/molmil-images/mine/6zlc) | Non-specific dsRNA recognition by wildtype H7N1 RNA-binding domain | 分子名称: | NITRATE ION, Non-structural protein 1, RNA (5'-R(*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*U)-3'), ... | 著者 | Coste, F, Wacquiez, A, Marc, D, Castaing, B. | 登録日 | 2020-06-30 | 公開日 | 2020-10-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1. Viruses, 12, 2020
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8BN8
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![BU of 8bn8 by Molmil](/molmil-images/mine/8bn8) | METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM3006 | 分子名称: | 2-[[4-(6-bromanyl-2~{H}-indazol-4-yl)-1,2,3-triazol-1-yl]methyl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]imidazo[1,2-a]pyridine, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit | 著者 | Pilka, E.S, Thomas, B, Blackaby, W, Hardick, D, Feeney, K, Ridgill, M, Rotty, B, Rausch, O. | 登録日 | 2022-11-13 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.213 Å) | 主引用文献 | Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity. Cancer Discov, 13, 2023
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1AZQ
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![BU of 1azq by Molmil](/molmil-images/mine/1azq) | HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SAC7D BOUND WITH KINKED DNA DUPLEX | 分子名称: | DNA (5'-D(*GP*TP*AP*AP*TP*TP*AP*C)-3'), PROTEIN (HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SAC7D) | 著者 | Robinson, H, Gao, Y.-G, Mccrary, B.S, Edmondson, S.P, Shriver, J.W, Wang, A.H.-J. | 登録日 | 1997-11-20 | 公開日 | 1999-01-13 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | The hyperthermophile chromosomal protein Sac7d sharply kinks DNA. Nature, 392, 1998
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8DAZ
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![BU of 8daz by Molmil](/molmil-images/mine/8daz) | Crystal structure of DMATS1 prenyltransferase in complex with L-Trp and GSPP | 分子名称: | Dimethylallyltryptophan synthase 1, GERANYL S-THIOLODIPHOSPHATE, TRYPTOPHAN | 著者 | Eaton, S.A, Ronnebaum, T.A, Roose, B.W, Christianson, D.W. | 登録日 | 2022-06-14 | 公開日 | 2022-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase N -Dimethylallyl-l-tryptophan Synthase from Fusarium fujikuroi . Biochemistry, 61, 2022
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5M8N
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![BU of 5m8n by Molmil](/molmil-images/mine/5m8n) | Crystal structure of human tyrosinase related protein 1 in complex with mimosine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | 登録日 | 2016-10-29 | 公開日 | 2017-07-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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5J9C
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![BU of 5j9c by Molmil](/molmil-images/mine/5j9c) | Crystal structure of peroxiredoxin Asp f3 C31S/C61S variant | 分子名称: | MAGNESIUM ION, peroxiredoxin Asp f3 | 著者 | Bzymek, K.P, Williams, J.C, Hong, T.B, Bagramyan, K, Kalkum, M. | 登録日 | 2016-04-08 | 公開日 | 2016-09-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.956 Å) | 主引用文献 | The Crystal Structure of Peroxiredoxin Asp f3 Provides Mechanistic Insight into Oxidative Stress Resistance and Virulence of Aspergillus fumigatus. Sci Rep, 6, 2016
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7U0Z
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![BU of 7u0z by Molmil](/molmil-images/mine/7u0z) | High-resolution map of tau filament from progressive supranuclear palsy (PSP) case 1 | 分子名称: | Isoform Tau-E of Microtubule-associated protein tau | 著者 | FItzpatrick, A.W.P, Stowell, M.H.B, Chang, A, Xiang, X, Wang, J, Lee, C, Arakhamia, T, Simjanoska, M, Wang, C, Carlomagno, Y, Zhang, G, Dhingra, S, Thierry, M, Perneel, J, Heeman, B, Forgrave, L.M, DeTure, M, DeMarco, M.L, Cook, C.N, Rademakers, R, Dickson, D, Petrucelli, L, Mackenzie, I.R.A. | 登録日 | 2022-02-19 | 公開日 | 2022-03-23 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell, 185, 2022
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5M8M
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![BU of 5m8m by Molmil](/molmil-images/mine/5m8m) | Crystal structure of human tyrosinase related protein 1 in complex with kojic acid | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | 登録日 | 2016-10-29 | 公開日 | 2017-07-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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6VD1
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![BU of 6vd1 by Molmil](/molmil-images/mine/6vd1) | Crystal structure of Arabidopsis thaliana S-adenosylmethionine Synthase 2 (AtMAT2) in complex with S-adenosylmethionine and PPNP | 分子名称: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, 1,3-PROPANDIOL, ... | 著者 | Sekula, B, Ruszkowski, M, Dauter, Z. | 登録日 | 2019-12-23 | 公開日 | 2020-02-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | S-adenosylmethionine synthases in plants: Structural characterization of type I and II isoenzymes from Arabidopsis thaliana and Medicago truncatula. Int.J.Biol.Macromol., 151, 2020
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6J6H
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![BU of 6j6h by Molmil](/molmil-images/mine/6j6h) | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | 分子名称: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | 登録日 | 2019-01-15 | 公開日 | 2019-04-24 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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6ZGI
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![BU of 6zgi by Molmil](/molmil-images/mine/6zgi) | Furin Cleaved Spike Protein of SARS-CoV-2 in Closed Conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Wrobel, A.G, Benton, D.J, Rosenthal, P.B, Gamblin, S.J. | 登録日 | 2020-06-18 | 公開日 | 2020-07-01 | 最終更新日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects. Nat.Struct.Mol.Biol., 27, 2020
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7LMB
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![BU of 7lmb by Molmil](/molmil-images/mine/7lmb) | Tetrahymena telomerase T5D5 structure at 3.8 Angstrom | 分子名称: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | 著者 | He, Y, Wang, Y, Liu, B, Helmling, C, Susac, L, Cheng, R, Zhou, Z.H, Feigon, J. | 登録日 | 2021-02-05 | 公開日 | 2021-05-12 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structures of telomerase at several steps of telomere repeat synthesis. Nature, 593, 2021
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5M8P
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![BU of 5m8p by Molmil](/molmil-images/mine/5m8p) | Crystal structure of human tyrosinase related protein 1 in complex with tyrosine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | 登録日 | 2016-10-29 | 公開日 | 2017-07-12 | 最終更新日 | 2022-12-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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6YX1
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![BU of 6yx1 by Molmil](/molmil-images/mine/6yx1) | Crystal structure of SHANK1 PDZ in complex with a peptide-small molecule hybrid | 分子名称: | 2-[[2-(5-oxidanylidenepentanoyl)hydrazinyl]methyl]benzoic acid, ARGININE, LEUCINE, ... | 著者 | Hegedus, Z, Hobor, F, Shoemark, D.K, Celis, S, Lian, L.J, Trinh, C.H, Sessions, R.B, Edwards, T.A, Wilson, A.J. | 登録日 | 2020-04-30 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation. Chem Sci, 12, 2021
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6TCP
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![BU of 6tcp by Molmil](/molmil-images/mine/6tcp) | Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form II | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Omalizumab Fab Leu158Pro light chain mutant, ... | 著者 | Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M. | 登録日 | 2019-11-06 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76, 2020
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