8Q9Q

Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC7 deacetylase binding motif

Summary for 8Q9Q

Entry DOI	10.2210/pdb8q9q/pdb
Descriptor	HDAC7 (histone deacetylase 7) binding motif peptide: GLY-VAL-VAL-LYS-GLN-LYS-LEU-ALA-GLU-VAL-ILE-LEU-LYS-LYS-GLN, MEF2D protein, MADS box dsDNA: AACTATTTATAAGA, ... (5 entities in total)
Functional Keywords	transcriptional repressor, transcription
Biological source	Homo sapiens More
Total number of polymer chains	5
Total formula weight	32748.83
Authors	Chinellato, M.,Carli, A.,Perin, S.,Mazzocato, Y.,Biondi, B.,Di Giorgio, E.,Brancolini, C.,Angelini, A.,Cendron, L. (deposition date: 2023-08-20, release date: 2024-04-17)
Primary citation	Chinellato, M.,Perin, S.,Carli, A.,Lastella, L.,Biondi, B.,Borsato, G.,Di Giorgio, E.,Brancolini, C.,Cendron, L.,Angelini, A. Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol., 436:168541-168541, 2024 Cited by PubMed: 38492719 DOI: 10.1016/j.jmb.2024.168541 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation